1012054-73-7

Basic information

• Product Name: N₁-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N₅-hydroxyglutaramide
• Synonyms: N₁-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N₅-hydroxyglutaramide
• CAS NO: 1012054-73-7
• Molecular Weight: 447.853
• Mol File: 1012054-73-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N₁-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N₅-hydroxyglutaramide(CAS DataBase Reference)
• NIST Chemistry Reference: N₁-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N₅-hydroxyglutaramide(1012054-73-7)
• EPA Substance Registry System: N₁-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-N₅-hydroxyglutaramide(1012054-73-7)

Safety Data

• Hazardous Substances Data: 1012054-73-7(Hazardous Substances Data)

Upstream product

• 53449-14-2 7-chloro-6-nitro-4(3H)-quinazolinone 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 55496-69-0 4-chloro-7-methoxy-6-nitroquinazoline 
• 1012057-47-4 7-methoxy-6-nitroquinazolin-4(3H)-one 
• 179552-75-1 N⁴-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine 
• 1012057-48-5 N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine hydrochloride 
• 31374-18-2 7-chloro-3,4-dihydroquinazolin-4-one 
• 1146957-64-3 Methyl 3-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)propanoate 
• 1012057-49-6 methyl 3-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)butanoate 

Relevant articles and documents

FORMULATION OF QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY

The present invention relates to a composition comprising an inclusion complex of a cyclodextrin and quinazoline containing zinc-binding moiety based derivatives. The cyclodextrin is preferable a β-cyclodextrin or a derivative thereof. The quinazolines have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS

The present invention relates to the compositions, methods, and applications of a novel approach to selective inhibition of several cellular or molecular targets with a single small molecule. More specifically, the present invention relates to multi-functional small molecules wherein one functionality is capable of inhibiting histone deacetylases (HDAC) and the other functionality is capable of inhibiting a different cellular or molecular pathway involved in aberrant cell proliferation, differentiation or survival.