101207-45-8

Basic information

• Product Name: 2-(4-methylbenzyl)-1H-isoindol-1,3(2H)-dione
• Synonyms: 2-(4-methylbenzyl)-1H-isoindol-1,3(2H)-dione
• CAS NO: 101207-45-8
• Molecular Weight: 251.285
• Mol File: 101207-45-8.mol
• Article Data: 25

Chemical Properties

• Melting Point: 147-148 °C
• Boiling Point: 407.0±24.0 °C(Predicted)
• Density: 1.274±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(4-methylbenzyl)-1H-isoindol-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylbenzyl)-1H-isoindol-1,3(2H)-dione(101207-45-8)
• EPA Substance Registry System: 2-(4-methylbenzyl)-1H-isoindol-1,3(2H)-dione(101207-45-8)

Safety Data

• Hazardous Substances Data: 101207-45-8(Hazardous Substances Data)

Usage

Isoindolone derivative

A compound that contains the isoindolone structural motif, which is a core structure found in many organic compounds.

4-methylbenzyl group

A functional group consisting of a benzyl group (a phenyl group attached to a methyl group) attached to the isoindolone ring.

Pharmacological properties

The potential for the compound to have effects on biological systems, making it of interest in the field of medicinal chemistry.

Organic synthesis

The study of the compound as a potential building block for the preparation of more complex molecules.

Building block

A simple molecule that can be used to create more complex molecules through chemical reactions.

Upstream product

• 136918-14-4 phthalimide 
• 106-43-4 para-chlorotoluene 
• 85-44-9 phthalic anhydride 
• 104-84-7 para-methylbenzylamine 
• 7677-24-9 trimethylsilyl cyanide 
• 88-67-5 2-Iodobenzoic acid 
• 1074-82-4 potassium phtalimide 
• 104-82-5 4-Methylbenzyl chloride 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 589-18-4 4-Methylbenzyl alcohol 
• 104-81-4 4-Methylbenzyl bromide 
• 38846-64-9 2-ethynylbenzaldehyde 
• 104-87-0 4-methyl-benzaldehyde 
• 40739-81-9 p-tolualdehyde p-toluenesulfonylhydrazone 

Downstream Products

• 88-99-3 benzene-1,2-dicarboxylic acid 
• 104-84-7 para-methylbenzylamine 
• 877149-98-9 2-(4-methylbenzyl)isoindolin-1-one 
• 612-14-6 phthalyl alcohol 
• 104-85-8 para-methylbenzonitrile 
• 67237-87-0 3-(4-methylphenyl)isoquinoline 
• 1197914-31-0 2-(4-methylbenzyl)-2,3-dihydro-1H-isoindole 
• 65608-94-8 N-(p-methylbenzyl)benzamide 
• 101367-16-2 2-{[4-(bromomethyl)phenyl]methyl}-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

Palladium-catalyzed double carbonylation reactions of o-dihaloarenes with amines in phosphonium salt ionic liquids

Palladium-catalyzed double carbonylation of o-dihaloarenes with amines in phosphonium salt ionic liquids proceeds efficiently to give the corresponding N-substituted phthalimides. This process can tolerate a wide array of functional groups and affords products in excellent yields. The recyclability of the catalytic system was also investigated.

Palladium-catalyzed carbonylative synthesis of phthalimides from 1,2-dibromoarenes with molybdenum hexacarbonyl as carbon monoxide source

We describe here a convenient and mild, carbon monoxide gas-free palladium-catalyzed procedure to obtain N-substituted phthalimides with molybdenum hexacarbonyl as carbon monoxide precursor. These conditions tolerate a number of functional groups on the benzene ring as well as a number of amines and give the corresponding phthalimides in good to excellent yields. Copyright

Nitrile Synthesis by Aerobic Oxidation of Primary Amines and in situ Generated Imines from Aldehydes and Ammonium Salt with Grubbs Catalyst

Herein, a Grubbs-catalyzed route for the synthesis of nitriles via the aerobic oxidation of primary amines is reported. This reaction accommodates a variety of substrates, including simple primary amines, sterically hindered β,β-disubstituted amines, allylamine, benzylamines, and α-amino esters. Reaction compatibility with various functionalities is also noted, particularly with alkenes, alkynes, halogens, esters, silyl ethers, and free hydroxyl groups. The nitriles were also synthesized via the oxidation of imines generated from aldehydes and NH4OAc in situ. (Figure presented.).

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.