101421-61-8

Basic information

• Product Name: 2-bromo-5-methylbenzamide
• Synonyms: 2-bromo-5-methylbenzamide
• CAS NO: 101421-61-8
• Molecular Weight: 214.062
• Mol File: 101421-61-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-bromo-5-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-5-methylbenzamide(101421-61-8)
• EPA Substance Registry System: 2-bromo-5-methylbenzamide(101421-61-8)

Safety Data

• Hazardous Substances Data: 101421-61-8(Hazardous Substances Data)

Upstream product

• 409110-31-2 2-bromo-5-methylbenzoyl chloride 
• 618-47-3 m-toluamide 
• 6967-82-4 2-bromo-5-methylbenzoic acid 
• 42872-83-3 2-bromo-5-methylbenzylnitrile 

Downstream Products

• 58814-46-3 7-methyl-3-phenylisoquinolin-1-amine 
• 1029009-22-0 3-(4-methoxyphenyl)-7-methylisoquinolin-1-amine 
• 1425605-57-7 5-methyl-2-(phenylethynyl)benzamide 
• 1425605-62-4 5-methyl-2-(pentadec-1-yn-1-yl)benzamide 
• 1425605-64-6 2-((4-methoxyphenyl)ethynyl)-5-methylbenzamide 
• 618-47-3 m-toluamide 
• 82256-11-9 2-(4-methoxyphenyl)-6-methylquinazolin-4(3H)-one 
• 1159410-96-4 benzyl 1,2-dihydro-3,7-dimethyl-1-oxoisoquinoline-4-carboxylate 

Relevant articles and documents

An efficient hydration of nitriles to amides in aqueous media by hydrotalcite-clay supported nickel nanoparticles

Hydrotalcite-clay supported nickel nanoparticles catalyze hydration of nitriles to amides in aqueous media. This Ni NPs/HT system is efficient for the synthesis of a diverse range of amides and affords the expected products with good yields in aqueous media. The synthesized nickel nanoparticles are characterized by UV-DRS, powder XRD, SEM and HRTEM. The catalyst is reused at least three times and a plausible mechanism is proposed. This fast, simple, effective and environmentally benign heterogeneous protocol provides a safer alternative to hazardous, corrosive and more polluting conventional catalysts.

Acid-promoted palladium(II)-catalyzed ortho-halogenation of primary benzamides: En route to halo-arenes

Br?nsted acid-promoted palladium(II)-catalyzed regioselective installation of halogens (Br, Cl, and I) to the aromatic ring of benzamide derivatives has been achieved using primary amides. A wide variety of benzamides were compatible under established conditions to afford the halogenated products without installing any external auxiliary. Mild reaction conditions, use of primary amide as a directing group, external additive-free conditions, and gram-scale reaction are some appealing features of this protocol. Detailed experimental results revealed that Br?nsted acid plays a critical role in this transformation.

Synthesis of 1-aminoisoquinolines by gold(III)-mediated domino reactions from 2-alkynylbenzamides and ammonium acetate

A facile synthetic route toward pharmaceutically interesting 1-aminoisoquinoline derivatives by gold(III)-mediated domino reactions is described. This synthetic protocol starts from readily available 2-alkynylbenzamides and ammonium acetate and takes plac