82256-11-9

Upstream product

• 696-62-8 para-iodoanisole 
• 40545-33-3 2-amino-5-methylbenzamide 
• 144-62-7 oxalic acid 
• 42872-83-3 2-bromo-5-methylbenzylnitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 101421-61-8 2-bromo-5-methylbenzamide 
• 874-90-8 4-methoxybenzonitrile 
• 3878-46-4 ethyl phenyl carbonate 
• 102-09-0 bis(phenyl) carbonate 
• 1224442-33-4 N-[imino(4-methoxyphenyl)methyl]-5-methyl-2-nitrobenzamide 
• 57774-72-8 ethyl p-methoxy-phenyl-carbothionylcarbamate 
• 106-49-0 p-toluidine 
• 82256-03-9 [1-(4-Methoxy-phenyl)-1-p-tolylamino-meth-(E)-ylidene]-carbamic acid ethyl ester 

Relevant academic research and scientific papers

Polystyrene-Supported Palladium (Pd?PS)-Catalyzed Carbonylative Annulation of Aryl Iodides Using Oxalic Acid as a Sustainable CO Source for the Synthesis of 2-Aryl Quinazolinones

An efficient and convenient strategy for the synthesis of diversely substituted quinazolinones from o-carbamoyl/cyano aniline and aryl iodides using oxalic acid as a CO source under polystyrene supported palladium (Pd?PS) nanoparticles (NPs) catalyzed con

“On-water” synthesis of quinazolinones and dihydroquinazolinones starting from O-bromobenzonitrile

A versatile and practical “on-water” protocol was newly developed to synthesize quinazolinones using o-bromobenzonitrile as a novel starting material. Studies have found that air as well as water plays an important role in synthesis of quinazolinones. Further investigation indicated that dihydroquinazolinones can be prepared with this protocol under the protection of N2. The protocol can be extended to other substrates and various quinazolinones and dihydroquinazolinones were obtained. o-Bromobenzamide, o-aminobenzonitrile, and o-aminobenzamide were also evaluated as starting materials, and the results further proved the versatility of this protocol, especially towards dihydroquinazolinones.

Rapid assembly of quinazolinone scaffold via copper-catalyzed tandem reaction of 2-bromobenzamides with aldehydes and aqueous ammonia: Application to the synthesis of the alkaloid tryptanthrin

An efficient and practical procedure for the preparation of 2-substituted and 2,3-disubstituted quinazolinones was achieved through copper-catalyzed tandem reaction of 2-bromobenzamides with aldehydes and aqueous ammonia under air. Control experimental results indicated that this tandem reaction is triggered by a copper-catalyzed direct amination of 2-bromobenzamides with aqueous ammonia, followed by cyclocondensation and oxidative aromatization. As an application, this novel methodology provides a concise and practical one-pot route to the synthesis of alkaloid tryptanthrin. This journal is

Synthesis of 2-arylquinazolin-4(3H)-ones by N-aryl benzamidines with aromatic carbonates

The reaction of N-aryl benzamidines 1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h, 1i, 1j, 1k, 1l, 1m, 1n with diphenyl carbonate 2a or ethyl phenyl carbonate 2b synthesized 2-arylquinazolin-4(3H)-ones 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 3k, 3l, 3m, 3n in simple and

Catalyst/ligand-free synthesis of benzimidazoles and quinazolinones from amidines via intramolecular transamination reaction

An efficient catalyst/ligand-free synthesis of benzimidazoles and quinazolinones from amidines in quantitative yields has been described.

N-Ethoxycarbonylamidines as Starting Materials and Intermediates in the Synthesis of Heterocyclic Compounds

Treatment of N-ethoxycarbonylthioamides (1) with primary aromatic amines yields N-aryl-N'-ethoxycarbonylamidines (2), which thermally cyclize to 2-aryl-4(3H)-quinazolines (6).Analogous reactions of 1 with ethyl 3-aminocrotonate and with 2-amino-2-thiazoli