101494-95-5

Basic information

• Product Name: 8-CHLOROQUINAZOLIN-4(1H)-ONE
• Synonyms: 8-CHLOROQUINAZOLIN-4(1H)-ONE;8-chloroquinazolin-4(3H)-one;8-chloroquinazolin-4-ol
• CAS NO: 101494-95-5
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.59
• Mol File: 101494-95-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 302℃
• Appearance: /
• Density: 1.50±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 8-CHLOROQUINAZOLIN-4(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-CHLOROQUINAZOLIN-4(1H)-ONE(101494-95-5)
• EPA Substance Registry System: 8-CHLOROQUINAZOLIN-4(1H)-ONE(101494-95-5)

Safety Data

• Hazardous Substances Data: 101494-95-5(Hazardous Substances Data)

Usage

General Description

8-Chloroquinazolin-4(1H)-one is a chemical compound belonging to the class of quinazolinones, which are known for their various biological activities. It is a derivative of quinazoline and contains a chlorine atom at the 8th position on the quinazolinone ring. 8-CHLOROQUINAZOLIN-4(1H)-ONE has been studied for its potential medicinal properties, including its antitumor and anti-inflammatory activities. The chlorine substitution may affect the compound's pharmacological properties and potential as a drug candidate. 8-Chloroquinazolin-4(1H)-one is of interest to researchers and scientists for its potential applications in the development of new pharmaceutical drugs and in various chemical and biological research studies.

Upstream product

• 491-36-1 4-Hydroxyquinazoline 
• 6388-47-2 2-amino-3-chlorobenzoic acid 
• 77287-34-4 formamide 
• 7477-63-6 7-chloroisatin 
• 67-56-1 methanol 
• 18343-44-7 2-amino-3-chloro-benzamide 
• 7782-50-5 chlorine 
• 7705-08-0 iron(III) chloride 
• 64-19-7 acetic acid 

Downstream Products

• 1421611-34-8 2-{2-[6-(8-chloro-4-oxo-4H-quinazolin-3-yl)-pyrimidin-4-yloxy]phenyl}-3-methoxy-acrylic acid methyl ester 
• 7148-34-7 4,8-dichloroquinazoline 

Relevant articles and documents

Acceptorless Dehydrogenative Coupling of o-Aminobenzamides with the Activation of Methanol as a C1 Source for the Construction of Quinazolinones

A strategy for the synthesis of quinazolinones via acceptorless coupling of o-aminobenzamides with methanol has been accomplished in the presence of the metal-ligand bifunctional catalyst [Cp?Ir(2,2′-bpyO)(H2O)]. Notably, this research exhibited the potential of transition-metal-catalyzed activation of methanol as a C1 source for the construction of heterocycles.

Method of synthesizing quinazolinone derivative by using methanol as raw material

The invention discloses a method of synthesizing a quinazolinone derivative by using methanol as a raw material. The method comprises adding an anthranilamide derivative II, methanol III and an iridium metal complex in a reaction container; performing a reaction on the reaction mixture in a microwave reactor or under magnetic stirring at a temperature of 130 +/- 10 DEG C for 2 hours or more; performing cooling to a room temperature; removing a solvent in a spin drying manner; and performing column separation to obtain a target compound. The method provided by the invention adopts nontoxic and renewable methanol as a raw material, and the by-products in the reaction are hydrogen gas and water, thus the method does not pollute the environment and meet the requirements of green chemistry, so that the method has a wide development prospect.

Quinazoline Compounds

Disclosed are quinazoline-based modulators of Liver X receptors (LXRs) and related methods. The modulators include compounds of formula (I): in which R1, R2, R3, R4, R5, R6, R7,