101653-22-9

Upstream product

• 75-16-1 methylmagnesium bromide 
• 333-27-7 methyl trifluoromethanesulfonate 
• 82495-67-8 1,2-bis(dichlorophosphanyl)benzene 
• 1393723-32-4 C₁₄H₂₂P₂ 
• 1393723-37-9 C₁₄H₂₈B₂P₂ 
• 677-22-5 tert-butylmagnesium chloride 
• 676-58-4 methylmagnesium chloride 
• 583-53-9 2,3-dibromobenzene 
• 263563-97-9 (S)-(tert-butyl)(methyl)phosphine-borane 
• 1354744-11-8 C₁₁H₁₆BrP 
• 1245628-41-4 (Rp)-(2-bromophenyl)(tert-butyl)(methyl)phosphine-borane 
• 263768-77-0 (±)-tert-butylmethylphosphine borane 

Relevant academic research and scientific papers

PHOSPHINE TRANSITION METAL COMPLEX, METHOD FOR PRODUCING THE SAME AND ANTICANCER AGENT

PROBLEM TO BE SOLVED: To provide a phosphine transition metal complex having excellent solubility to aqueous solvent, and higher anticancer activity than that of conventional cisplatin, and an anticancer agent including the same and a method for producing a phosphine transition metal complex using the same. SOLUTION: The present invention provides a phosphine transition metal complex represented by formula (1) (where R1-R4 and R6-R9 each denote an alkyl group, a cycloalkyl group, or an adamantyl group, R5 and R10 each denote a monovalent substituent, n and y each denote an integer of 0-4, M is a transition metal atom selected from gold, copper, silver). SELECTED DRAWING: None COPYRIGHT: (C)2020,JPO&INPIT

SYNTHESIS METHOD OF α,β-UNSATURATED CARBOXYLIC ACID

PROBLEM TO BE SOLVED: To provide a synthesis method of α,β-unsaturated carboxylic acid capable of improving a generation amount of the α,β-unsaturated carboxylic acid. SOLUTION: A synthetic method of α,β-unsaturated carboxylic acid, which includes to form a metal lactone compound having a specific structure as an intermediate body by reacting alkene and carbon dioxide with a transition metal complex under the presence of Lewis acid and a base to form a metal lactone compound having a specific structure as an intermediate body and to act the Lewis acid and base on the metal lactone compound, the relationship between the acid dissociation constant of the base (pKa1) of a conjugate acid of the base and the acid dissociation constant (pKa2) of the α,β-unsaturated carboxylic acid is pKa1pKa2. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPO&INPIT

Method for synthesizing alpha, beta-unsaturated acid by using formic acid and alkine

The invention relates to a method for synthesizing alpha, beta-unsaturated acid by using formic acid and alkine, in particular to a method for synthesizing alpha, beta-unsaturated acid by using formic acid and alkine under the effect of a nickel catalyst. The consumption of the catalyst is 0.01 to 2 mol percent of the quantity of a substrate substance; the consumption of estolide is 3 to 30 mol percent of the quantity of the substrate substance; the pressure of acetylene gas is 1 to 10 MPa; the reaction temperature is 25 to 100 DEG C; the reaction time is 5 to 12 hours. The method has the advantages that the existing alkine hydrocarboxylation defects are overcome; the use of toxic carbon monoxide gas does not needed; the reaction conditions of the whole process are mild; the efficiency is high; the selectivity is good; the method belongs to a method for preparing the alpha, beta-unsaturated acid with the advantages that the method conforms to green chemistry and has good application aspects; good industrial application prospects are realized.

Synthesis, reactivity, and resolution of a C 2-symmetric, P-stereogenic benzodiphosphetane, a building block for chiral bis(phosphines)

Although the pyramidal inversion barriers in diphosphines (R 2P-PR2) are similar to those in phosphines (PR 3), P-stereogenic chiral diphosphines have rarely been exploited as building blocks in asymmetric synthesis. The synthesis, reactivity, and resolution of the benzodiphosphetane trans-1,2-(P(t-Bu))2C 6H4 are reported. Alkylation with MeOTf followed by addition of a nucleophile gave the useful C2-symmetric P-stereogenic ligand BenzP* and novel analogues.

Rigid P-chiral phosphine ligands with tert -butylmethylphosphino groups for rhodium-catalyzed asymmetric hydrogenation of functionalized alkenes

Both enantiomers of 2,3-bis(tert-butylmethylphosphino)quinoxaline (QuinoxP*), 1,2-bis(tert-butylmethylphosphino)benzene (BenzP*), and 1,2-bis(tert-butylmethylphosphino)-4,5-(methylenedioxy)benzene (DioxyBenzP*) were prepared in short steps from enantiopure (S)- and (R)-tert-butylmethylphosphine-boranes as the key intermediates. All of these ligands were crystalline solids and were not readily oxidized on exposure to air. Their rhodium complexes exhibited excellent enantioselectivities and high catalytic activities in the asymmetric hydrogenation of functionalized alkenes, such as dehydroamino acid derivatives and enamides. The practical utility of these catalysts was demonstrated by the efficient preparation of several chiral pharmaceutical ingredients having an amino acid or a secondary amine component. A rhodium complex of the structurally simple ligand BenzP* was used for the mechanistic study of asymmetric hydrogenation. Low-temperature NMR studies together with DFT calculations using methyl α-acetamidocinnamate as the standard model substrate revealed new aspects of the reaction pathways and the enantioselection mechanism.