10167-35-8 Usage
Description
3-Phenylmethyl-3,4-dihydro-1,4-benzodiazepin-2,5-dione, commonly known as Flurazepam, is a benzodiazepine class drug that functions as a sedative and hypnotic medication. It is primarily used to treat insomnia and other sleep disorders by binding to specific brain receptors and enhancing the calming effects of the neurotransmitter gamma-aminobutyric acid (GABA).
Uses
Used in Pharmaceutical Industry:
3-Phenylmethyl-3,4-dihydro-1,4-benzodiazepin-2,5-dione is used as a sedative and hypnotic agent for the treatment of insomnia and other sleep disorders. It is prescribed for short-term use to manage sleep issues due to its potential for dependence and tolerance development when used long-term.
Used in Sleep Aid Formulations:
3-Phenylmethyl-3,4-dihydro-1,4-benzodiazepin-2,5-dione is used as an active ingredient in sleep aid formulations to promote sleep and improve sleep quality. It is available in the form of oral tablets and should be used under the guidance of a healthcare professional to avoid potential adverse effects and dependence.
Check Digit Verification of cas no
The CAS Registry Mumber 10167-35-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,6 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 10167-35:
(7*1)+(6*0)+(5*1)+(4*6)+(3*7)+(2*3)+(1*5)=68
68 % 10 = 8
So 10167-35-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H14N2O2/c19-15-12-8-4-5-9-13(12)17-16(20)14(18-15)10-11-6-2-1-3-7-11/h1-9,14H,10H2,(H,17,20)(H,18,19)
10167-35-8Relevant articles and documents
New synthesis of 1,4 benzodiazepine-2,5-diones by means of HCl gas catalyst
Akssira,Boumzebra,Kasmi,Dahdouh,Roumestant,Viallefont
, p. 2265 - 2272 (1993)
A new synthesis of 1,4-benzodiazepinediones 4, particularly 1,4-dihydro1H-1,4-benzodiazepine-2,5-dione, 4c key intermediate of metabolites cyclopenin 9, cyclopenol 10, cyclopeptine 11 and dehydrocyclopeptide 12, was achieved by action of dry HCl gas in DM
A novel one step approach to the synthesis of 3H-1,4-benzodiazepin-(1H,4H)-2,5-diones from 1,2,3-benzotriazin-4-(3H)-one
Gupta, Renu,Sirohi, Reenu,Shastri, Sudha,Kishore
, p. 363 - 366 (2003)
1,2,3-Benzotriazin-4-(3H)-one(3) and its 6-chloro derivative (4) on thermal condensation with α-amino acids yielded 3H-1,4-benzodiazepin-(1H,4H)-2,5-diones(7-12) in moderate to good yield. The cyclocondensation is believed to proceed through the formation of an iminoketene intermediate (5).
Simple synthesis, structure and ab initio study of 1,4-benzodiazepine-2,5- diones
Jadidi, Khosrow,Aryan, Reza,Mehrdad, Morteza,Lügger, Thomas,Ekkehardt Hahn,Ng, Seik Weng
, p. 37 - 42 (2007/10/03)
A simple procedure for the synthesis of pyrido[2,1-c][1,4] benzodiazepine-6,12-dione (1) and 1,4-benzodiazepine-2,5-diones (2a-2d), using microwave irradiation and/or conventional heating is reported. The configuration of 1 was determined by single-crysta
