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10167-35-8

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10167-35-8 Usage

Description

3-Phenylmethyl-3,4-dihydro-1,4-benzodiazepin-2,5-dione, commonly known as Flurazepam, is a benzodiazepine class drug that functions as a sedative and hypnotic medication. It is primarily used to treat insomnia and other sleep disorders by binding to specific brain receptors and enhancing the calming effects of the neurotransmitter gamma-aminobutyric acid (GABA).

Uses

Used in Pharmaceutical Industry:
3-Phenylmethyl-3,4-dihydro-1,4-benzodiazepin-2,5-dione is used as a sedative and hypnotic agent for the treatment of insomnia and other sleep disorders. It is prescribed for short-term use to manage sleep issues due to its potential for dependence and tolerance development when used long-term.
Used in Sleep Aid Formulations:
3-Phenylmethyl-3,4-dihydro-1,4-benzodiazepin-2,5-dione is used as an active ingredient in sleep aid formulations to promote sleep and improve sleep quality. It is available in the form of oral tablets and should be used under the guidance of a healthcare professional to avoid potential adverse effects and dependence.

Check Digit Verification of cas no

The CAS Registry Mumber 10167-35-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,6 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 10167-35:
(7*1)+(6*0)+(5*1)+(4*6)+(3*7)+(2*3)+(1*5)=68
68 % 10 = 8
So 10167-35-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H14N2O2/c19-15-12-8-4-5-9-13(12)17-16(20)14(18-15)10-11-6-2-1-3-7-11/h1-9,14H,10H2,(H,17,20)(H,18,19)

10167-35-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-benzyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione

1.2 Other means of identification

Product number -
Other names 3H-3-benzyl-1,4-benzodiazepin-(1H,4H)-2,5-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10167-35-8 SDS

10167-35-8Relevant articles and documents

New synthesis of 1,4 benzodiazepine-2,5-diones by means of HCl gas catalyst

Akssira,Boumzebra,Kasmi,Dahdouh,Roumestant,Viallefont

, p. 2265 - 2272 (1993)

A new synthesis of 1,4-benzodiazepinediones 4, particularly 1,4-dihydro1H-1,4-benzodiazepine-2,5-dione, 4c key intermediate of metabolites cyclopenin 9, cyclopenol 10, cyclopeptine 11 and dehydrocyclopeptide 12, was achieved by action of dry HCl gas in DM

A novel one step approach to the synthesis of 3H-1,4-benzodiazepin-(1H,4H)-2,5-diones from 1,2,3-benzotriazin-4-(3H)-one

Gupta, Renu,Sirohi, Reenu,Shastri, Sudha,Kishore

, p. 363 - 366 (2003)

1,2,3-Benzotriazin-4-(3H)-one(3) and its 6-chloro derivative (4) on thermal condensation with α-amino acids yielded 3H-1,4-benzodiazepin-(1H,4H)-2,5-diones(7-12) in moderate to good yield. The cyclocondensation is believed to proceed through the formation of an iminoketene intermediate (5).

Simple synthesis, structure and ab initio study of 1,4-benzodiazepine-2,5- diones

Jadidi, Khosrow,Aryan, Reza,Mehrdad, Morteza,Lügger, Thomas,Ekkehardt Hahn,Ng, Seik Weng

, p. 37 - 42 (2007/10/03)

A simple procedure for the synthesis of pyrido[2,1-c][1,4] benzodiazepine-6,12-dione (1) and 1,4-benzodiazepine-2,5-diones (2a-2d), using microwave irradiation and/or conventional heating is reported. The configuration of 1 was determined by single-crysta

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