10176-66-6

Basic information

• Product Name: nevadensin
• Synonyms: 2-(4-Methoxyphenyl)-5,7-dihydroxy-6,8-dimethoxy-4H-1-benzopyran-4-one;4',6,8-Trimethoxy-5,7-dihydroxyflavone;Nevadensin A;4H-1-Benzopyran-4-one, 5,7-dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)-;5,7-Dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;5,7-Dihydroxy-6,8,4'-trimethoxyflavone
• CAS NO: 10176-66-6
• Molecular Formula: C₁₈H₁₆O₇
• Molecular Weight: 344.32
• Mol File: 10176-66-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 199-200℃ (chloroform methanol )
• Boiling Point: 615°C at 760 mmHg
• Flash Point: 227°C
• Appearance: /
• Density: 1.387g/cm³
• Vapor Pressure: 1.02E-15mmHg at 25°C
• Refractive Index: 1.627
• PKA: 6.84±0.40(Predicted)
• CAS DataBase Reference: nevadensin(CAS DataBase Reference)
• NIST Chemistry Reference: nevadensin(10176-66-6)
• EPA Substance Registry System: nevadensin(10176-66-6)

Safety Data

• Hazardous Substances Data: 10176-66-6(Hazardous Substances Data)

Usage

Definition

ChEBI: A trimethoxyflavone that is flavone substituted by methoxy groups at positions 6, 8 and 4' and hydroxy groups at positions 5 and 7 respectively.

InChI:InChI=1/C18H16O7/c1-22-10-6-4-9(5-7-10)12-8-11(19)13-14(20)17(23-2)15(21)18(24-3)16(13)25-12/h4-8,20-21H,1-3H3

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 67-56-1 methanol 
• 520-36-5 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 
• 480-41-1 naringenin 
• 5128-44-9 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 10236-47-2 naringin 
• 124-41-4 sodium methylate 

Downstream Products

• 481-53-8 tangeritin 
• 10211-35-5 diacetylnevadensin 

Related news

Metabolism profiling of nevadensin (cas 10176-66-6) in vitro and in vivo by UHPLC-Q-TOF-MS/MS07/21/2019

Nevadensin is major constituents of Lysionotus pauciflorus Maxim. (Chinese name: Shidiaolan), which has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive. In this paper, we investigated the metabolism of ...detailed

nevadensin (cas 10176-66-6) is a naturally occurring selective inhibitor of human carboxylesterase 107/19/2019

Human carboxylesterase 1 (hCE1) is a key enzyme responsible for the hydrolysis of a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors against hCE1 are rarely reported. This study aimed to assess the inhibitory effects of natural flavonoids against hCE1 and to fi...detailed

Relevant articles and documents

Nevadensin glycosides from Lysionotus pauciflorus

Two new flavone glucosides, nevadensin 5-O-β-D-glucoside and nevadensin 5-O-β-D-glucosyl(1 → 6)β-D-glucoside, have been isolated from the aerial parts of Lysionotus pauciflorus. The structures have been determined by means of UV, mass spectral and one- and two-dimensional 1H and 13C NMR techniques.

Lysionotin preparation method

The invention provides a lysionotin preparation method. The lysionotin preparation method is characterized by including preparation steps: step one, adopting phloroglucinol and acetic anhydride as reaction materials, and performing Friedel-Crafts reaction under catalysis of boron trifluoride diethyl etherate to obtain 2,4,6-trihydroxyacetophone; step two, subjecting 2,4,6-trihydroxyacetophone obtained at the step one to annulation reaction with p-anisoyl chloride under catalysis of potassium carbonate to obtain 5,7-dyhydroxy-4'-methoxyflavone; step three, subjecting 5,7-dyhydroxy-4'-methoxyflavone to free radical reaction under catalysis of NBS to obtain 5,7-dyhydroxy-6,8-dibromo-4'-methoxyflavone; step four, subjecting 5,7-dyhydroxy-6,8-dibromo-4'-methoxyflavone obtained at the step three to methoxylation reaction with sodium methylate under catalysis of cuprous bromide to obtain lysionotin.