10179-57-4

Usage

Uses

Used in Biological Research:
4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide is used as a research tool for studying the role of Cdc42 in various cellular processes. Its specificity for Cdc42 allows researchers to investigate the effects of inhibiting this particular GTPase on cell behavior and signaling pathways.
Used in Drug Discovery:
As a specific inhibitor of Cdc42, 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide may be utilized in drug discovery efforts targeting the Rho family of GTPases. Its ability to selectively inhibit Cdc42 could lead to the development of new therapeutic agents for diseases associated with the dysregulation of this protein.
Used in Pharmaceutical Development:
4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide is used as a lead compound in the development of pharmaceuticals that modulate Cdc42 activity. Its high specificity and cell permeability make it a promising candidate for further optimization and potential clinical applications.

in vitro

mls-573151 was a specific, cell permeable inhibitor of cdc42 with an ic50 of 2 μm [1]. mls-573151 showed no effect on other gtpases, including the related rho family members rhoa, rac1, and rac2. mls-573151 functioned by blocking the binding of gtp to cdc42 [1]. in marrow-derived mesenchymal stem cells, mls-573151 showed no effect on cell migration [3].

References

1) Surviladze et al. (2010), Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay; J. Biomol. Screening, 15 10 2) Wang et al. (2017), Cannabinoid Receptor 1 Mediates Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury; J. Cell Physiol., 232 110

Upstream product

• 94-41-7 benzalacetophenone 
• 4392-54-5 4-aminosulfonylphenylhydrazine 
• 17852-52-7 4-hydrazinobenzene-1-sulfonamide hydrochloride 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 

Downstream Products

• 78794-55-5 4-(3,5-diphenyl-1H-pyrazol-1-yl)benzenesulfonamide 

Relevant academic research and scientific papers

Synthesis of sulfonamides bearing 1,3,5-triarylpyrazoline and 4-thiazolidinone moieties as novel antimicrobial agents

Two series of sulfonamides were synthesized from 4-hydrazinylben-zenesulfonamide as the key starting material. 1,3,5-Triarylpyrazoline sulfonamides (2a-i) were obtained by cyclocondensation of various chalcones in 53-64 % yields, while 4-thiazolidinone derivatives (4a-e) were synthesized by cyclocondensation between mercaptoacetic acid and different phenylhydrazones in 43-62 % yields. The synthesized compounds were characterized based on FTIR, 1H-NMR, 13C-NMR and HRMS data. The sulfonamides were evaluated for their in vitro antimicrobial activities against four bacterial strains (E. coli, P. aeruginosa, B. subtillis and S aureus), two filamentous fungal strains (A. Niger and F. oxysporum) and two yeast strains (C. albicans and S. cerevisiae). Seven pyrazolines, 2a-c and 2e-h, exhibited significant inhibition of different microbial strains. Among them, compound 2b displayed good antifungal activity against A. Niger (MIC value at 12.5 μg mL-1) over the reference drug.

Inhibitors of Yellow Fever Virus replication based on 1,3,5-triphenyl-4,5-dihydropyrazole scaffold: Design, synthesis and antiviral evaluation

By the antiviral screening of an in house library of pyrazoline compounds, 4-(3-(4-phenoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide (5a) was identified as a promising hit compound for the development of anti- Yellow Fever Virus (YFV)

Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines

4-(3-(4-Substituted-phenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamides (9–16) were successfully synthesized and their chemical structures were confirmed by 1H NMR, 13C NMR, and HRMS spectra. Carbonic anhydrase I and II inhibitory effects of the compounds were investigated. Ki values of the compounds were in the range of 316.7 ± 9.6–533.1 ± 187.8 nM towards hCA I and 412.5 ± 115.4–624.6 ± 168.2 nM towards hCA II isoenzymes. While Ki values of the reference compound Acetazolamide were 278.8 ± 44.3 nM and 293.4 ± 46.4 nM towards hCA I and hCA II izoenzymes, respectively. Compound 14 with bromine and compound 13 with fluorine substituents can be considered as the leader compounds of the series because of the lowest Ki values in series to make further detailed carbonic anhydrase inhibiton studies.

Synthesis, molecular docking study, and cytotoxic activity of 1,3,5-triaryl pyrazole derivatives

Synthesis, molecular docking study, and cytotoxic activity of a new group of 1,3,5-triaryl pyrazole derivatives were be studied. The antiproliferative activity of the final compounds were examined in MCF-7, AGS, HT-29 and NIH3T3 cell lines by MTT assay, u