10199-51-6

Basic information

• Product Name: ETHYL 1-METHYL-5-PHENYL-1H-PYRAZOLE-3-CARBOXYLATE
• Synonyms: ETHYL 1-METHYL-5-PHENYL-1H-PYRAZOLE-3-CARBOXYLATE;Ethyl 1-methyl-5-phenyl-1H-pyrazole-3-carboxylate 97%;Ethyl 1-Methyl-5-phenylpyrazole-3-carboxylate;1-methyl-5-phenyl-1H-prazole-3-carboxylic acid ethyl ester;1H-Pyrazole-3-carboxylic acid, 1-methyl-5-phenyl-, ethyl ester
• CAS NO: 10199-51-6
• Molecular Formula: C₁₃H₁₄N₂O₂
• Molecular Weight: 230.26
• Mol File: 10199-51-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 380.6°Cat760mmHg
• Flash Point: 184°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 5.39E-06mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: ETHYL 1-METHYL-5-PHENYL-1H-PYRAZOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 1-METHYL-5-PHENYL-1H-PYRAZOLE-3-CARBOXYLATE(10199-51-6)
• EPA Substance Registry System: ETHYL 1-METHYL-5-PHENYL-1H-PYRAZOLE-3-CARBOXYLATE(10199-51-6)

Safety Data

• Hazardous Substances Data: 10199-51-6(Hazardous Substances Data)

Usage

General Description

ETHYL 1-METHYL-5-PHENYL-1H-PYRAZOLE-3-CARBOXYLATE is a chemical compound with the molecular formula C14H14N2O2. It is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. ETHYL 1-METHYL-5-PHENYL-1H-PYRAZOLE-3-CARBOXYLATE has a pyrazole core structure, which makes it useful in the development of various drugs and agrochemicals. It also possesses potential biological activities, such as anti-inflammatory and analgesic properties. ETHYL 1-METHYL-5-PHENYL-1H-PYRAZOLE-3-CARBOXYLATE is a valuable chemical with diverse applications in the field of medicinal and organic chemistry.

InChI:InChI=1/C13H14N2O2/c1-3-17-13(16)11-9-12(15(2)14-11)10-7-5-4-6-8-10/h4-9H,3H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 7339-53-9 methyl hydrazine hydrochloride 
• 60178-91-8 ethyl 1-methyl-5-oxo-4,5-dihydro-1H-pyrazole-3-carboxylate 
• 98-80-6 phenylboronic acid 
• 40876-98-0 sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 5932-30-9 ethyl 5-phenylpyrazole-3-carboxylate 
• 77-78-1 dimethyl sulfate 
• 302-15-8 methylhydrazine sulfuric acid 
• 74-88-4 methyl iodide 
• 852816-29-6 2-bromo[methylhydrazono]acetic acid ethyl ester 
• 3453-00-7 diethyl benzoylmethylphosphonate 
• 60-34-4 methylhydrazine 
• 98-86-2 acetophenone 

Downstream Products

• 10250-63-2 1-methyl-3-phenyl-1H-prazole-5-carboxylic acid ethyl ester 
• 10199-53-8 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid 
• 1622170-63-1 (4-(5-(1-methyl-5-phenyl-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)methanol 
• 1622170-64-2 4-(5-(1-methyl-5-phenyl-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde 
• 1622170-65-3 [3-({4-[5-(1-methyl-5-phenyl-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl]benzyl}amino)propyl]phosphonic acid 
• 859850-98-9 1-methyl-5-phenyl-1H-pyrazole-3-carbonyl chloride 
• 869901-13-3 3-chloromethyl-1-methyl-5-phenyl-1H-pyrazole 
• 124344-98-5 (1-methyl-5-phenyl-1H-pyrazol-3-yl)methanol 

Relevant articles and documents

New pyrazolium-carboxylates as structural analogues of the pseudo-cross-conjugated betainic alkaloid nigellicine

Pyrazolium-3-carboxylates were examined as relatives of the betainic alkaloid Nigellicine and as new examples of the sparsely populated class 16 of heterocyclic pseudo-cross-conjugated mesomeric betaines (PCCMB). The title compounds were prepared in a 4-step procedure starting from β-diketo compounds 8 which were cyclized with substituted hydrazines. The resulting isomeric pyrazole esters 9 and 10 were separated and subsequently quaternized with dimethyl sulfate in the presence of nitrobenzene to pyrazolium esters 11 and 12. Saponification was best accomplished in diluted sulfuric acid, which resulted in the formation of the pseudo-cross-conjugated mesomeric betaines 13 and 14 in one step. Protonation to the corresponding carboxylic acids required the treatment of the betaines with tetrafluoroboric acid in dichloromethane. The effect of negative solvatochromism proves the charge separation in the ground state of the molecules. X-ray crystallographic analyses, semiempirical calculations, and ESI mass spectrometric measurements were performed to gain knowledge about the phenomenon of pseudo-cross-conjugation.

N-hydroxyl-5-substituted-1H-pyrazol-3-formamide compound as well as preparation method and use thereof

The invention belongs to the field of medicine chemistry, and particularly relates to an N-hydroxyl-5-substituted-1H-pyrazol-3-formamide compound as well as a preparation method and use thereof. The specific structure of the compound is as shown in a formula I. The invention also provides a synthesis method of the compound in the formula I and inhibition activity thereof for acidic sphingomyelinase. The compound can be used for developing drugs for treating atherosclerosis (AS), diabetes, emphysema, pulmonary edema, pulmonary fibrosis, cystic fibrosis, chronic obstructive pulmonary disease, pulmonary arterial hypertension, non-alcoholic fatty liver disease, Alzheimers (AD), multiple sclerosis (MS), cerebral stroke and depression diseases. (the formula I is shown in the description).

C3-CARBON LINKED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION

This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.