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10250-63-2

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  • SAGECHEM/ Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate /Manufacturer in China

    Cas No: 10250-63-2

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10250-63-2 Usage

General Description

Ethyl 1-Methyl-3-Phenyl-1H-Pyrazole-5-Carboxylate is a chemical compound that belongs to the family of Pyrazoles. This chemical is particularly used in the synthesis of various pharmaceutical drugs because of its properties as an analgesic, anti-inflammatory, anti-cancer, anti-bacterial, and anti-fungal agent. Its molecular formula is C14H14N2O2 and it appears as a white crystalline solid substance with a stable nature under normal temperature and pressure, but it can cause skin, eye, and respiratory tract irritation. It is recommended to handle it with proper protective gear and ventilation to prevent any health hazards. Its synthesis involves the reaction of phenylhydrazine with ethyl acetoacetate, followed by cyclization, methylation, and decarboxylation.

Check Digit Verification of cas no

The CAS Registry Mumber 10250-63-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,2,5 and 0 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 10250-63:
(7*1)+(6*0)+(5*2)+(4*5)+(3*0)+(2*6)+(1*3)=52
52 % 10 = 2
So 10250-63-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H14N2O2/c1-3-17-13(16)12-9-11(14-15(12)2)10-7-5-4-6-8-10/h4-9H,3H2,1-2H3

10250-63-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 2-methyl-5-phenylpyrazole-3-carboxylate

1.2 Other means of identification

Product number -
Other names 1-methyl-3-phenyl-1H-prazole-5-carboxylic acid ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10250-63-2 SDS

10250-63-2Relevant articles and documents

FIVE-MEMBERED HETEROCYCLIC AMIDES WNT PATHWAY INHIBITOR

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Paragraph 0176; 0178; 0179, (2018/10/19)

The present invention discloses a five-membered heterocyclic amide WNT pathway inhibitor, which belongs to a compound that regulates the activity of a Wnt signaling pathway, and provides a method for preparing such a compound, and the use of such a compound in preparing a medicament that antagonizes the Wnt signaling pathway. The five-membered heterocyclic amide WNT pathway inhibitor provided by the invention has a remarkable anti-tumor activity based on a target-based rational drug design of, and can be used for the development of a new generation of Wnt pathway inhibitors, and has a great clinical application value and considerable market potential.

SUBSTITUTED 1H-PYRAZOL-1,2,4-OXADIAZOLE DERIVATIVES AS SPHINGOSINE RECEPTOR MODULATORS

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Paragraph 196-198, (2014/09/03)

The present invention relates to substituted 1H-pyrazol-1,2,4-oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

New pyrazolium-carboxylates as structural analogues of the pseudo-cross-conjugated betainic alkaloid nigellicine

Schmidt, Andreas,Habeck, Tobias,Kindermann, Markus Karl,Nieger, Martin

, p. 5977 - 5982 (2007/10/03)

Pyrazolium-3-carboxylates were examined as relatives of the betainic alkaloid Nigellicine and as new examples of the sparsely populated class 16 of heterocyclic pseudo-cross-conjugated mesomeric betaines (PCCMB). The title compounds were prepared in a 4-step procedure starting from β-diketo compounds 8 which were cyclized with substituted hydrazines. The resulting isomeric pyrazole esters 9 and 10 were separated and subsequently quaternized with dimethyl sulfate in the presence of nitrobenzene to pyrazolium esters 11 and 12. Saponification was best accomplished in diluted sulfuric acid, which resulted in the formation of the pseudo-cross-conjugated mesomeric betaines 13 and 14 in one step. Protonation to the corresponding carboxylic acids required the treatment of the betaines with tetrafluoroboric acid in dichloromethane. The effect of negative solvatochromism proves the charge separation in the ground state of the molecules. X-ray crystallographic analyses, semiempirical calculations, and ESI mass spectrometric measurements were performed to gain knowledge about the phenomenon of pseudo-cross-conjugation.

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