102022-17-3

Upstream product

• 772-03-2 2-vinylquinoline 
• 98-86-2 acetophenone 
• 63487-23-0 β-N,N-dimethylaminoethylquinaldine 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 1323154-02-4 2-(3-(2-phenyl-1,3-dioxolan-2-yl)propyl)quinoline 
• 58521-76-9 2-(2-bromoethyl)-2-phenyl-[1,3]dioxolane 
• 29636-75-7 3-bromo-1-phenylpropan-1-one 
• 71-43-2 benzene 
• 100-58-3 phenylmagnesium bromide 
• 91-63-4 2-methylquinoline 

Relevant academic research and scientific papers

Silver-Promoted Radical Ring-Opening/Pyridylation of Cyclobutanols with N-Methoxypyridinium Salts

The silver-promoted reaction of tertiary cyclobutanols with N-methoxypyridinium salts enables the efficient synthesis of a range of C2-substituted pyridines. The overall process likely occurs by ring-opening (via β-scission) of the cyclobutoxy radical to generate the corresponding γ-keto alkyl radical that itself adds to the pyridinium salt. A wide range of tertiary cyclobutanols and N-methoxypyridinium salts are compatible with the reaction conditions.

Rapid Construction of Structurally Diverse Quinolizidines, Indolizidines, and Their Analogues via Ruthenium-Catalyzed Asymmetric Cascade Hydrogenation/Reductive Amination

A rapid construction of enantioenriched benzo-fused quinolizidines, indolizidines, and their analogues by ruthenium-catalyzed asymmetric cascade hydrogenation/reductive amination of quinolinyl- and quinoxalinyl-containing ketones has been developed. This

Enantioselective synthesis of quinolizidines and indolizidines via a catalytic asymmetric hydrogenation cascade

A catalytic enantioselective synthesis of a new class of quinolizidines and indolizidines is presented. An asymmetric Bronsted acid catalyzed hydrogenation cascade as well as a sequential Bronsted acid/metal catalyzed hydrogenation protocol of 2-substituted quinolines yields benzofused quinolizidines and indolizidines in good yields with high diastereo- and enantioselectivities. Georg Thieme Verlag Stuttgart - New York.