102045-96-5

Basic information

• Product Name: (S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid
• Synonyms: (S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid;1,3-Dioxolane-4-carboxylicacid,2,2-dimethyl-,(4S)-(9CI);1,3-Dioxolane-4-carboxylic acid, 2,2-dimethyl-, (4S)-;(S)-2,3-(Isopropylidenedioxy)propionic acid;(S)-2,2-Dimethyldioxolane-4-carboxylic acid
• CAS NO: 102045-96-5
• Molecular Formula: C₆H₁₀O₄
• Molecular Weight: 146.1412
• Product Categories: CARBOXYLICACID
• Mol File: 102045-96-5.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 244.151°C at 760 mmHg
• Flash Point: 101.605°C
• Appearance: /
• Density: 1.203g/cm³
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.447
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid(102045-96-5)
• EPA Substance Registry System: (S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid(102045-96-5)

Safety Data

• Hazardous Substances Data: 102045-96-5(Hazardous Substances Data)

Usage

General Description

(S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid is a chemical compound that belongs to the class of carboxylic acids. It is a white solid with a molecular formula of C7H12O4 and a molecular weight of 160.17 g/mol. (S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid is used in the synthesis of pharmaceuticals and agrochemicals, and it also has potential applications in the field of materials science. Its unique structure, containing a dioxolane ring and a carboxylic acid group, makes it a valuable building block for the development of new compounds with specific properties and functionalities. Overall, (S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid is an important and versatile chemical that has diverse applications in various industries.

InChI:InChI=1/C6H10O4/c1-6(2)9-3-4(10-6)5(7)8/h4H,3H2,1-2H3,(H,7,8)/t4-/m0/s1

Upstream product

• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 
• 117205-81-9 potassium (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 60456-21-5 methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 14347-78-5 1,2-O-isopropylidene-D-glycerol 
• 22323-80-4 (4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 108865-84-5 methyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate 

Downstream Products

• 99566-52-6 (S)-(2,2-dimethyl-1,3-dioxolan-4-yl)ethanone 
• 68981-29-3 C₁₈H₂₃N₃O₈ 
• 240125-23-9 5-[(1S)-1,2-O-isopropylideneglycol-1-yl]-3-ethoxycarbonyl-1-benzyl-1,2,4-triazole 
• 645393-94-8 (4'R,7S)-9-(2',2'-dimethyl-[1',3']dioxolan-4'-yl)-7-(4''-methoxybenzyloxymethyl)-3,3,8-trimethyl-2,4-dioxa-spiro[5.5]undec-8-ene-1,5-dione 
• 645393-95-9 (4'R,7R)-9-(2',2'-dimethyl-[1',3']dioxolan-4'-yl)-7-(4''-methoxybenzyloxymethyl)-3,3,8-trimethyl-2,4-dioxa-spiro[5.5]undec-8-ene-1,5-dione 
• 645393-93-7 (4R)-(E)-4-[4-(4-methoxybenzyloxy)-2-methyl-1-methylenebut-2-enyl]-2,2-dimethyl-[1,3]dioxolane 
• 645393-92-6 (4S)-(E)-1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-4-(4-methoxybenzyloxy)-2-methylbut-2-en-1-one 
• 930795-40-7 (4E)-1-((1R,2S)-1-(2-cyanoethyl)-2-(triethylsilanyloxymethyl)-3-methyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)cyclohex-3-enyl)-5-((2R,3R,5R)-5-(3-triisopropylsilanyloxypropyl)-3-methyltetrahydrofuran-2-yl)hex-4-enyl acetate 
• 930795-43-0 (4E)-1-((1R,2S)-1-(2-cyanoethyl)-2-ethynyl-3-methyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)cyclohex-3-enyl)-5-((2R,3R,5R)-5-(3-triisopropylsilanyloxypropyl)-3-methyltetrahydrofuran-2-yl)hex-4-enyl acetate 
• 930795-41-8 (4E)-1-((1R,2S)-1-(2-cyanoethyl)-2-(hydroxymethyl)-3-methyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)cyclohex-3-enyl)-5-((2R,3R,5R)-5-(3-triisopropylsilanyloxypropyl)-3-methyltetrahydrofuran-2-yl)hex-4-enyl acetate 
• 930795-42-9 acetic acid 1-[1-(2-cyano-ethyl)-4-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-formyl-3-methyl-cyclohex-3-enyl]-5-[3-methyl-5-(3-triisopropylsilanyloxy-propyl)-tetrahydro-furan-2-yl]-hex-4-enyl ester 
• 930795-39-4 1-((1R,2S)-1-(2-cyanoethyl)-2-(triethylsilanyloxymethyl)-3-methyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)cyclohex-3-enyl)allyl acetate 
• 930795-33-8 (1'R,2'S,4''R)-3-[4'-(2'',2''-dimethyl-[1'',3'']dioxolan-4''-yl)-3'-methyl-1'-(1'''-hydroxyallyl)-2'-triethylsilanyloxymethylcyclohex-3'-enyl]propionitrile 
• 930795-32-7 (1'R,2'S,4''R)-3-[1'-formyl-4'-(2'',2''-dimethyl-[1'',3'']dioxolan-4''-yl)-3'-methyl-2'-triethylsilanyloxymethylcyclohex-3'-enyl]propionitrile 

Relevant articles and documents

Mapping the substrate selectivity of new hydrolases using colorimetric screening: Lipases from Bacillus thermocatenulatus and Ophiostoma piliferum, esterases from Pseudomonas fluorescens and Streptomyces diastatochromogenes

Recent advances in biochemistry and molecular biology have simplified the discovery and preparation of new hydrolases. Although these hydrolases might solve problems in organic synthesis, measuring their selectivity, especially enantioselectivity, remains tedious and time consuming. Recently, we developed a colorimetric screening method to measure the enantioselectivity of hydrolases. Here we apply this rapid screening method to map the substrate selectivity of four new hydrolases: lipases from the thermophilic Bacillus thermocatenulatus (DSM 730, BTL2) and a filamentous fungus Ophiostoma piliferum (NRRL 18917, OPL) and esterases from two bacteria, Pseudomonas fluorescens (SIK-W1, esterase I, PFE) and Streptomyces diastatochromogenes (Tue 20, SDE). We screened a general library of 29 substrates and a chiral library of 23 pairs of enantiomers. All four hydrolases catalysed the hydrolysis of unnatural substrates, but the two lipases accepted a broader range of substrates than the two esterases. As expected, the two lipases favoured more hydrophobic substrates, while the two esterases showed a preference for smaller substrates. Several moderately enantioselective reactions were identified for the solketal esters: BTL2, butyrate, E = 7.9 (R); octanoate, E = 4.9 (R) and 3-bromo-2-methyl propionate methyl esters, PFE, E = 12 (S); SDE, E = 5.6 (S). OPL showed low enantioselectivity toward all substrates tested. The current colorimetric screen could not measure the selectivity for several slow-reacting substrates. Traditional screening identified high enantioselectivity of BTL2 and PFE toward one of these slow substrates, 1-phenylethyl acetate (E>50).

THERAPEUTIC METHODS

The invention provides methods and compositions for delivering a nucleic acid to a cell or the cytosol of the target cell. The method includes contacting the cell with, 1) a membrane-destabilizing polymer; and 2) a nucleic acid conjugate. The nucleic acid conjugate includes a targeting ligand bound to an optional linker and a nucleic acid.

TARGETED COMPOSITIONS

The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

STEROL DERIVATIVES AND USE THEREOF FOR TREATING DISEASES INVOLVING TRANSFORMED ASTROCYTE CELLS OR FOR TREATING MALIGNANT HAEMOPATHIES

The invention relates to novel sterol derivatives, the preparation method thereof, pharmaceutical compositions containing them and use thereof for treating diseases involving transformed astrocyte cells or for treating malignant haemopathies. The inventio