102092-51-3

Basic information

• Product Name: 3-BROMO-4'-METHYLBENZOPHENONE
• Synonyms: 3-BROMO-4'-METHYLBENZOPHENONE;UKRORGSYN-BB BBV-5119987;(3-BroMophenyl)(4-Methylphenyl)Methanone
• CAS NO: 102092-51-3
• Molecular Formula: C₁₄H₁₁BrO
• Molecular Weight: 275.14
• Mol File: 102092-51-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 107-108.5 °C
• Boiling Point: 385.9°C at 760 mmHg
• Flash Point: 86.5°C
• Appearance: /
• Density: 1.375g/cm³
• Vapor Pressure: 3.68E-06mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-BROMO-4'-METHYLBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4'-METHYLBENZOPHENONE(102092-51-3)
• EPA Substance Registry System: 3-BROMO-4'-METHYLBENZOPHENONE(102092-51-3)

Safety Data

• Hazardous Substances Data: 102092-51-3(Hazardous Substances Data)

Usage

General Description

3-Bromo-4'-methylbenzophenone is a chemical compound that belongs to the benzophenone family. It contains a bromine atom and a methyl group attached to a benzophenone core, which is a commonly used building block in organic synthesis. 3-BROMO-4'-METHYLBENZOPHENONE has applications as a UV filter in sunscreens and as a photoinitiator in photopolymerization processes. It is also used as a pharmaceutical intermediate in the production of various drugs. 3-Bromo-4'-methylbenzophenone is known for its ability to absorb and dissipate UV radiation, making it a valuable ingredient in sun protection products. Additionally, it can be used as a starting material for the synthesis of more complex organic compounds.

InChI:InChI=1/C14H11BrO/c1-10-5-7-11(8-6-10)14(16)12-3-2-4-13(15)9-12/h2-9H,1H3

Upstream product

• 108-36-1 1,3-dibromobenzene 
• 104-85-8 para-methylbenzonitrile 
• 591-18-4 1-Bromo-3-iodobenzene 
• 5720-05-8 4-methylphenylboronic acid 
• 13939-06-5 molybdenum hexacarbonyl 
• 6952-59-6 3-cyanobromobenzene 
• 624-31-7 4-tolyl iodide 
• 98-59-9 p-toluenesulfonyl chloride 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 122334-36-5 N-methoxy-N,4-dimethylbenzamide 
• 585-76-2 m-bromobenzoic acid 
• 1711-09-7 3-bromobenzoyl chloride 
• 108-88-3 toluene 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 1292285-20-1 3-[9-(4-methylphenyl)-9H-fluoren-9-yl]diphenylamine 
• 1292285-19-8 9-(3-bromophenyl)-9-(4-methylphenyl)fluorene 
• 37825-81-3 4-methyl-3'-phenoxybenzhydrol 
• 243137-94-2 5-{3-(4-cyanobenzoyl)phenylethynyl}-2'-deoxy-5'-O-(4,4'-dimethoxytrityl) uridine 
• 243137-98-6 4-(3-trimethylsilylethynylbenzoyl)benzonitrile 
• 214548-26-2 4-(3-ethynylbenzoyl)benzonitrile 
• 243137-97-5 4-(3-bromobenzoyl)benzonitrile 
• 243137-96-4 4-(3-bromobenzoyl)benzaldehyde 
• 1026827-53-1 3'-bromo-4-(dibromomethyl)benzophenone 
• 33757-34-5 3-bromo-α-(4-methylphenyl)benzenemethanol 

Relevant articles and documents

STUDIES IN TRIFLUOROMETHANESULPHONIC ACID-IV KINETICS AND MECHANISM OF ACYLATION OF AROMATIC COMPOUNDS

A detailed kinetic study has been made of acylation reactions in solvent trifluoromethane sulphonic acid (CF3SO3H) using carboxylic acids as the electrophilic species involved.These species were shown to be probably the protonated form of the mixed anhydride.The reactions show high substrate selectivity characterised by high negative values of p+.Substituents in the carboxylic acids have a relatively small influence on the reactions rates due to a cancellation of substituents effects on the protonation of the mixed anhydride with those operating on the subsequent slow reaction of these species with the aromatic substrate.Anomalous effects were found for certain ortho substituents.The overall mechanism is discussed in terms of polar and steric effects in conjunction with the competing protonation of the aromatic bases, together with evidence from isotope effects.

Ni/Ti Dual Catalytic Cross-Coupling of Nitriles and Organobromides to Access Ketones

Herein, we report the development of a dual catalytic approach for the cross-coupling of nitriles with aryl- and aliphatic-bromides. A titanium(III) catalyst is used to activate nitriles enabling their coupling with organobromides through a nickel catalyst. The Ni/Ti system efficiently prepared unsymmetrical ketones with good chemoselectivity and could selectively couple a bromide in the presence of other functionalizable handles.

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

A small library of 36 functionalized benzophenone thiosemicarbazone analogs has been prepared by chemical synthesis and evaluated for their ability to inhibit the cysteine proteases cathepsin L and cathepsin B. Inhibitors of cathepsins L and B have the potential to limit or arrest cancer metastasis. The six most active inhibitors of cathepsin L (IC50 50 > 10,000 nM). The most active analog in the series, 3-bromophenyl-2′-fluorophenyl thiosemicarbazone 1, also efficiently inhibits cell invasion of the DU-145 human prostate cancer cell line.