102096-60-6 Usage
Description
(R)-(+)-ALPHA-ACRYLOYLOXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE is a versatile chemical compound characterized by its butyrolactone structure, featuring a beta,beta-dimethyl substitution and an alpha-acryloyloxy group. This lactone is widely recognized for its utility as a monomer in the synthesis of polymer materials with tailored physical and chemical attributes. Its unique structure also endows it with potential applications in the medical and pharmaceutical sectors, although it must be handled with caution due to its inherent hazards.
Uses
Used in Polymer Production:
(R)-(+)-ALPHA-ACRYLOYLOXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE is used as a monomer for the production of polymers with specific physical and chemical properties. Its incorporation into polymer chains allows for the creation of materials with tailored characteristics, such as improved strength, flexibility, or thermal stability, depending on the desired application.
Used in Organic Synthesis:
In the realm of organic synthesis, (R)-(+)-ALPHA-ACRYLOYLOXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE serves as a valuable reagent. Its unique structure facilitates various chemical reactions, making it instrumental in the synthesis of complex organic compounds and contributing to the advancement of chemical research and development.
Used in Medical and Pharmaceutical Applications:
Owing to its distinctive properties, (R)-(+)-ALPHA-ACRYLOYLOXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE holds promise in the medical and pharmaceutical industries. Its potential applications may include the development of new drugs, therapeutic agents, or diagnostic tools, although further research and development are necessary to fully explore and validate its utility in these areas.
Used in Research and Development:
(R)-(+)-ALPHA-ACRYLOYLOXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE is also utilized in research and development settings, where its unique structure and properties are explored for novel applications. Scientists and researchers leverage this compound to investigate new chemical reactions, material properties, and potential uses across various industries.
It is crucial to adhere to safety regulations and handle (R)-(+)-ALPHA-ACRYLOYLOXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE with care due to its potential hazards, ensuring the safety of both individuals and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 102096-60-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,0,9 and 6 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 102096-60:
(8*1)+(7*0)+(6*2)+(5*0)+(4*9)+(3*6)+(2*6)+(1*0)=86
86 % 10 = 6
So 102096-60-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H12O4/c1-4-6(10)13-7-8(11)12-5-9(7,2)3/h4,7H,1,5H2,2-3H3/t7-/m0/s1
102096-60-6Relevant articles and documents
DIASTEREOFACE-DISCRIMINATIVE METAL COORDINATION IN ASYMMETRIC SYNTHESIS: D-PANTOLACETONE AS PRACTICAL CHIRAL AUXILIARY FOR LEWIS ACID CATALYZED DIELS-ALDER REACTIONS
Poll, Thomas,Sobczak, Andrzej,Hartmann, Horst,Helmchen, Gunter
, p. 3095 - 3098 (1985)
TiCl4-catalyzed Diels-Alder additions of the acrylate of commercial D-pantoloacetone to cyclopentadiene, isoprene and butadiene proceed with very high diastereofacial selectivity.Practical and mechanistic aspects of these reactions are discussed.
Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection
Lazerwith, Scott E.,Lew, Willard,Zhang, Jennifer,Morganelli, Philip,Liu, Qi,Canales, Eda,Clarke, Michael O.,Doerffler, Edward,Byun, Daniel,Mertzman, Michael,Ye, Hong,Chong, Lee,Xu, Lianhong,Appleby, Todd,Chen, Xiaowu,Fenaux, Martijn,Hashash, Ahmad,Leavitt, Stephanie A.,Mabery, Eric,Matles, Mike,Mwangi, Judy W.,Tian, Yang,Lee, Yu-Jen,Zhang, Jingyu,Zhu, Christine,Murray, Bernard P.,Watkins, William J.
, p. 1893 - 1901 (2014/04/03)
Investigation of thiophene-2-carboxylic acid HCV NS5B site II inhibitors, guided by measurement of cell culture medium binding, revealed the structure-activity relationships for intrinsic cellular potency. The pharmacokinetic profile was enhanced through incorporation of heterocyclic ethers on the N-alkyl substituent. Hydroxyl groups were incorporated to modulate protein binding. Intrinsic potency was further improved through enantiospecific introduction of an olefin in the N-acyl motif, resulting in the discovery of the phase 2 clinical candidate GS-9669. The unexpected activity of this compound against the clinically relevant NS5B M423T mutant, relative to the wild type, was shown to arise from both the N-alkyl substituent and the N-acyl group.
Enzymatic kinetic resolution of pantolactone: Relevance to chiral auxiliary chemistry
Haughton, Louise,Williams, Jonathan M. J.,Zimmermann, Jochen A.
, p. 1697 - 1701 (2007/10/03)
Racemic pantolactone was converted into either enantiomerically enriched pantolactone acetate or pantolactone acrylate by an enzyme-catalysed kinetic resolution process. Pantolactone is known to be a good auxiliary for acrylate in the Diels-Alder reaction. (C) 2000 Elsevier Science Ltd.
