102121-98-2

Upstream product

• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 2377-81-3 tetrafluoroisophthalonitrile 
• 1146217-17-5 C₁₂H₁₃NO₂ 
• 1169983-32-7 2-(4-methoxybenzoylmethylene)-oxazolidine 
• 950997-87-2 C₁₁H₁₀ClNO₂ 
• 126978-95-8 1-(imidazolidin-2-ylidene)-propan-2-one 
• 64944-80-5 2-benzoylmethyleneimidazolidine 
• 82100-23-0 2-(imidazolidin-2-ylidene)-1-(p-tolyl)ethanone 
• 82100-30-9 1-phenyl-2-(tetrahydropyrimidin-2(1H)-ylidene)ethan-1-one 
• 115859-76-2 2-(tetrahydropyrimidin-2(1H)-ylidene)-1-(p-tolyl)ethan-1-one 
• 107165-82-2 2-(p-chlorobenzoylmethylene)imidazolidine 
• 107195-10-8 2-(imidazolidin-2-ylidene)-1-(4-methoxyphenyl)ethan-1-one 
• 107165-83-3 1-(4-chlorophenyl)-2-(tetrahydropyrimidin-2(1H)-ylidene)ethan-1-one 
• 107165-84-4 1-(4-methoxyphenyl)-2-(tetrahydropyrimidin-2(1H)-ylidene)ethan-1-one 

Downstream Products

• 1429124-31-1 C₁₄H₁₆FN₃S₂ 
• 1429124-27-5 C₂₆H₁₇N₃S₃ 
• 1429124-21-9 C₁₃H₁₅F₂N₅ 
• 152402-36-3 4-amino-2,5,6-trifluoroisophthalic acid diamide 

Relevant academic research and scientific papers

Introduction of several trifluoromethyl groups onto the activated aromatic materials with CF3TMS-CuI-KF system

Trifluoromethylation onto the tetrafluorophthalonitrile and tetrafluoroisophthalonitrile has been carried out using CF3TMS-CuI-KF system, and it was demonstrated that these trifluoromethylation enabled us to successfully construct di- and/or tr

An efficient one-pot synthesis of heterocycle-fused 1,2,3-triazole derivatives as anti-cancer agents

A series of heterocycle-fused 1,2,3-triazoles were easily prepared by the 1,3-dipolar cycloaddition of heterocyclic ketene aminals or N,O-acetals with sodium azide and polyhalo isophthalonitriles in a one-pot reaction at room temperature without a catalyst and evaluated in vitro against a panel of human tumour cell lines. 1,3-Oxazoheterocycle fused 1,2,3-triazoles were more potent against the tumour cell lines Skov-3, HL-60, A431, A549 and HepG-2 than 1,3-diazoheterocycle fused 1,2,3-triazoles. 4-Methoxyphenyl substituted 1,3-oxazoheterocycle fused 1,2,3-triazole 6j was found to be the most potent derivative with IC50 values lower than 1.9 μg/mL against A431 and K562 human tumour cell lines.

PRODUCTION OF 2-HALO-3,5-DIFLUOROANILINE, INTERMEDIATE FOR PRODUCING THE SAME, AND PRODUCTION OF SAID INTERMEDIATE

A process for producing 2-halo-3,5-difluoroaniline by heating 4-amino-5-halo-2,6-difluoroisophthalonitrile in the presence of sulfuric acid with a concentration of 50 wt.% or above at a temperature ranging from 80 °C to the boiling point of the reaction m

Fluorinated isophthalonitrile compound and nonmedical fungicide containing the same

A fluorinated isophthalonitrile compound having the general formula STR1 wherein Y is --O, --S, or --N(R'), R and R' are independently hydrogen, an alkyl group, an alkyl group, an alkynyl group, a haloalkyl group, an alkoxyl group, alkoxyalkyl group, a ph