10219-26-8

Usage

Uses

Used in Rubber and Plastic Industry:
N-Isopropyl-m-toluidine is used as an intermediate for the production of rubber and plastic materials, contributing to the development of various consumer and industrial products.
Used in Chemical Synthesis:
N-Isopropyl-m-toluidine is used as an intermediate in the synthesis of antioxidants, rubber accelerators, and dyes, playing a crucial role in the manufacturing process.
Used in Pharmaceutical Industry:
N-Isopropyl-m-toluidine is used as a building block for various active ingredients and intermediates in the production of pharmaceuticals, aiding in the development of new medications.
Used in Agrochemical Industry:
N-Isopropyl-m-toluidine is utilized as a building block for various active ingredients and intermediates in the production of agrochemicals, contributing to the development of agricultural products.

Upstream product

• 75-30-9 2-iodo-propane 
• 108-44-1 1-amino-3-methylbenzene 
• 555-31-7 aluminum isopropoxide 
• 67-63-0 isopropyl alcohol 
• 77-76-9 2,2-dimethoxy-propane 
• 116-11-0 2-Methoxypropene 
• 108-18-9 diisopropylamine 
• 591-17-3 meta-bromotoluene 
• 75-31-0 isopropylamine 

Downstream Products

• 26772-90-7 1-isopropyl-4-(3-methylphenyl)-3,4-dihydro-2(1H)-quinazolinone 
• 1357519-22-2 [iPrNH₂(3-MeC₆H₁₀)][HB(C₆F₅)3] 
• 26772-92-9 (1-isopropyl)-1-(m-tolyl)urea 
• 40507-24-2 2-(4-fluorobenzoyl)-N-isopropyl-5-methylaniline 
• 78649-81-7 2-(4-fluorobenzoyl)-N-isopropyl-3-methylaniline 

Relevant academic research and scientific papers

One-pot reductive amination of acetals with aromatic amines using decaborane (B10H14) in methanol

Aldehyde acetals and ketone ketals were reductively aminated in one pot with aromatic amines to give the corresponding amines in methanol or aqueous methanol in good to high yields. This direct method might be important because acetals and ketals are used as a popular protecting group for aldehyde and ketones. The advantage of our method is effective even in an aqueous solution and in the application to selective reaction.

GPhos Ligand Enables Production of Chiral N-Arylamines in a Telescoped Transaminase-Buchwald-Hartwig Amination Cascade in the Presence of Excess Amine Donor

The combination of biocatalysis and chemocatalysis can be more powerful than either technique alone. However, combining the two is challenging due to typically very different reaction conditions. Herein, chiral N-aryl amines, key features of many active pharmaceutical ingredients, are accessed in excellent enantioselectivity (typically>99.5 % ee) by combining transaminases with the Buchwald-Hartwig amination. By employing a bi-phasic buffer-toluene system as well as the ligand GPhos, the telescoped cascade proceeded with up to 89 % overall conversion in the presence of excess alanine. No coupling to alanine was observed.

Synthesis, reactivities, and catalytic properties of iodo-bridged polymeric iridium complexes with flexible carbon chain-bridged bis(tetramethylcyclopentadienyl) ligands

Dinuclear iridium complexes [(C5Me4)(CH 2)n(C5Me4)][Ir(COD)]2 (2a: n = 2; 2b: n = 3; 2c: n = 4) are obtained from the reactions of the corresponding dilithium salts Li2/sub

Aminohaloborane in Organic Synthesis. IX. Exclusive ortho Acylation Reaction of N-Monoaminoalkylanilines

The exclusive ortho acylation reaction of aniline derivatives using boron trichloride made possible the one-step synthesis of 2-acyl-N-monoaminoalkylanilines (1) and the corresponding imines (2) from N-monoaminoalkylanilines, even in the case of compounds with a bulky substituent at the nitrogen atom.Conventional methods only give 1 via elaborate procedures.Keywords: regioselective reaction; 2-acylaniline derivative; 2-acylaniline-imine derivative; boron trichloride

ALCOHOLS AND ALUMINIUM ALKOXIDES IN THE PRESENCE OF RANEY-NICKEL AS ALKYLATING AGENTS. II. A KINETIC STUDY OF ALKYLATION OF AROMATIC AMINES

The kinetics of N-alkylation of substituted anilines with isopropanol and aluminium isopropoxide, catalysed by Raney-nickel, have been studied.The reaction proceeds according to a second-order equation.The formation of the Schiff's bases of the anilines along the reaction courses have been detected.The data reported also show that the reaction rates depend upon the nucleophilicity of the substrate to be alkylated.A possible mechanism is discussed.