1023971-15-4

Basic information

• Product Name: RaceMic Fudosteine HCl
• Synonyms: RaceMic Fudosteine HCl;Racemic Fudosteine;2-amino-3-((3-hydroxypropyl)thio)propanoic acid hydrochloride
• CAS NO: 1023971-15-4
• Molecular Formula: C6H13NO3S
• Molecular Weight: 179.24
• Mol File: 1023971-15-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 354.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.301±0.06 g/cm3(Predicted)
• PKA: 2.09±0.10(Predicted)
• CAS DataBase Reference: RaceMic Fudosteine HCl(CAS DataBase Reference)
• NIST Chemistry Reference: RaceMic Fudosteine HCl(1023971-15-4)
• EPA Substance Registry System: RaceMic Fudosteine HCl(1023971-15-4)

Safety Data

• Hazardous Substances Data: 1023971-15-4(Hazardous Substances Data)

Upstream product

• 52-90-4 L-Cysteine 
• 107-18-6 allyl alcohol 
• 921-01-7 D-cysteine 
• 503-30-0 trimethylene oxide 
• 407-41-0 L-phosphoserine 
• 19721-22-3 3-sulfanylpropanol 
• 52-89-1 l-cysteine hydrochloride 
• 627-18-9 1-bromo-3-propanol 
• 627-30-5 1-chloro-3-hydroxypropane 
• 62116-24-9 3-acetoxypropyl iodide 
• 628-09-1 3-Chloropropyl acetate 
• 592-33-6 3-bromopropyl acetate 
• 353-05-9 3-fluoropropyl acetate 

Relevant articles and documents

Synthesis method of fudosteine

The invention relates to a synthesis method of fudosteine, and belongs to the field of biomedicine industry. According to the synthesis method, L-cysteine and acrolein are taken as the raw materials to carry out Michael addition reactions, then sodium borohydride is added to carry out reduction reactions, fudosteine is synthesized by a one-pot method, and finally fudosteine is re-crystallized to obtain high purity fudosteine. The reaction conditions of the preparation method are mild and controllable. The product yield is 95%, and the liquid phase purity is 99.8%.

Preparation method of high-purity fudosteine

The invention discloses a preparation method of high-purity fudosteine, and belongs to the technical field of synthesis of pharmaceutical compounds. The preparation method is characterized in that with 3-halogenated propyl acetate or 3-halogenated propyl propionate and L-cysteine as starting materials, a fudosteine crude product is prepared through a reaction in an aqueous alkali solution, and high-purity fudosteine is obtained by refining the fudosteine crude product. The preparation method has the advantages that the reaction conditions are mild, the reaction process is simple, the yield ishigh, the cost is low, the requirement that the content of unknown impurities is lower than 0.1% can be met, and the preparation method is suitable for industrial application.

Unnatural amino acid synthesis by thermostable O-phospho-L-serine sulfhydrylase from hyperthermophilic archaeon Aeropyrum pernix K1

O-Acetyl-L-serine sulfhydrylase (OASS) from plants and bacteria synthesizes cysteine and unnatural amino acids that are important building blocks for active pharmaceuticals and agrochemicals. A thermostable O-phospho-L-serine sulfhydrylase from hyperthermophilic archaeon Aeropyrum pernix K1 (OPSSAp) exhibits a function similar to OASS. In the present study, we examined the synthesis of various unnatural amino acids using OPSSAp and demonstrated OPSSAp could efficiently synthesize various sulfur-containing amino acids. OPSSAp would be useful for industrial production of biologically important unnatural amino acids.