1025-21-4

Upstream product

• 27067-40-9 1-(2,2-diphenylcyclopropyl)ethanone 
• 121-44-8 triethylamine 
• 75-50-3 trimethylamine 
• 78-94-4 methyl vinyl ketone 
• 530-48-3 1,1-Diphenylethylene 
• 67-64-1 acetone 
• 104543-14-8 5,5-diphenyl-2-nitro-2(pyridine-2-thiyl)pentane 
• 917-64-6 methyl magnesium iodide 
• 22156-48-5 3,3-diphenylpropionitrile 

Downstream Products

• 1021-88-1 1-methyl-4-phenyl-1,2,3,4-tetrahydro-naphthalene 
• 1021-89-2 4-Phenyl-1-methyl-3.4-dihydro-naphthalin 
• 13280-69-8 1-methyl-4-phenylnaphthalene 

Relevant academic research and scientific papers

A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters

We report herein the use of a dual catalytic system comprising a Lewis base catalyst such as quinuclidin-3-ol or 4-dimethylaminopyridine and a photoredox catalyst to generate carbon radicals from either boronic acids or esters. This system enabled a wide range of alkyl boronic esters and aryl or alkyl boronic acids to react with electron-deficient olefins via radical addition to efficiently form C?C coupled products in a redox-neutral fashion. The Lewis base catalyst was shown to form a redox-active complex with either the boronic esters or the trimeric form of the boronic acids (boroxines) in solution.

Photochemical Addition of Tertiary Amines to Electrophilic Cyclopropranes via Single Electron Transfer

Irradiation of arylcyclopropanes bearing at least one electron-withdrawing group with a tertiary amine in acetonitrile resulted in the formation of the regioselective addition product of the amine along with the reduction product.

THE INVENTION OF NEW RADICAL CHAIN REACTIONS. PART X. HIGH YIELD RADICAL ADDITION REACTIONS OF αβ-UNSATURATED NITROOLEFINS. AN EXPEDIENT CONSTRUCTION OF THE 25-HYDROXY-VITAMIN D3 SIDE CHAIN FROM BILE ACIDS.

Radicals derived from thiohydroxamic esters 3 readily add to nitroolefins 5 (Z=NO2) to give good yields of α-nitrosulphides.These adducts, where the structure permits, are easily oxidised to carboxylic acids 8 by treatment with alkaline hydrogen peroxide.Reductive cleavage to the corresponding aldehydes or ketones 9 is efficiently carried out by the action of TiCl3.Addition of methyl magnesium iodide to methyl ketone derived from 3α-acetoxy 11-oxo cholanic acid gives steroid 10 possessing the 25-hydroxycholesterol side chain of the vitamin D3 metabolites.Radical additions to 1-phenylthio-2-nitropropene 11 have been briefly studied.