10250-64-3

Basic information

• Product Name: 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
• Synonyms: 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID;1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid 97%;2-Methyl-5-phenyl-2H-pyrazole-3-carboxylic acid;1-methyl-3-phenyl-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE);5-Carboxy-1-methyl-3-phenyl-1H-pyrazole;1H-Pyrazole-5-carboxylic acid, 1-methyl-3-phenyl-
• CAS NO: 10250-64-3
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.21
• Mol File: 10250-64-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 186 °C
• Boiling Point: 419.6 °C at 760 mmHg
• Flash Point: 207.6 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 8.62E-08mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: 2-8°C
• PKA: 2.97±0.25(Predicted)
• CAS DataBase Reference: 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID(10250-64-3)
• EPA Substance Registry System: 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID(10250-64-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• WGK Germany: 3
• Hazardous Substances Data: 10250-64-3(Hazardous Substances Data)

Usage

Description

1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID is an organic compound characterized by a pyrazole ring and a carboxylic acid functional group. It is a white powder with a molecular formula of C11H10N2O2. This versatile intermediate is widely utilized in pharmaceutical research for the synthesis of biologically active compounds and drug candidates, owing to its unique molecular structure and properties. It also holds potential in the fields of medicinal chemistry and agrochemicals.

Uses

Used in Pharmaceutical Research:
1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID is used as a building block for the synthesis of various biologically active compounds and drug candidates. Its molecular structure and properties make it a valuable intermediate in the development of new drugs targeting diverse biological pathways.
Used in Medicinal Chemistry:
1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID is employed as a versatile intermediate in medicinal chemistry for the design and synthesis of novel therapeutic agents. Its unique structure and functional groups contribute to the creation of compounds with potential applications in treating various diseases and conditions.
Used in Agrochemicals:
1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID is used in the field of agrochemicals for the development of new compounds with potential applications in agriculture, such as pesticides, herbicides, and other crop protection agents. Its unique molecular structure and properties make it a promising candidate for the creation of innovative agrochemical products.

InChI:InChI=1/C11H10N2O2/c1-13-10(11(14)15)7-9(12-13)8-5-3-2-4-6-8/h2-7H,1H3,(H,14,15)

Upstream product

• 20577-73-5 methyl 4-phenyl-2,4-dioxobutanoate 
• 98-86-2 acetophenone 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 98-80-6 phenylboronic acid 
• 89088-56-2 methyl 1-methyl-3-aminopyrazole-5-carboxylate 
• 10250-63-2 1-methyl-3-phenyl-1H-prazole-5-carboxylic acid ethyl ester 
• 56426-35-8 methyl 5-phenyl-1H-pyrazole-3-carboxylate 
• 10250-62-1 1-Methyl-3-phenylpyrazol-5-carbonsaeure-methylester 

Downstream Products

• 1569316-89-7 C₂₁H₁₉N₅O₃ 
• 1569316-66-0 C₂₂H₂₁N₅O₃ 
• 1207725-94-7 C₂₁H₁₉N₅O₃ 
• 1227681-73-3 C₂₂H₂₁N₅O₃ 
• 1558041-33-0 N-((3R,5S)-1-(benzofuran-3-carbonyl)-5-(ethylcarbamoyl)pyrrolidin-3-yl)-1-methyl-3-phenyl-1H-pyrazole-5-carboxamide 
• 1415757-44-6 (R)-2-{3-fluoro-4-[(2-methyl-5-phenyl-2H-pyrazole-3-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester 
• 1207726-20-2 C₂₅H₂₃N₃O₃ 
• 1104267-88-0 1-methyl-3-phenyl-N-[(1-pyridin-3-ylcyclohexyl)methyl]-1H-pyrazole-5-carboxamide 

Relevant articles and documents

FIVE-MEMBERED HETEROCYCLIC AMIDES WNT PATHWAY INHIBITOR

The present invention discloses a five-membered heterocyclic amide WNT pathway inhibitor, which belongs to a compound that regulates the activity of a Wnt signaling pathway, and provides a method for preparing such a compound, and the use of such a compound in preparing a medicament that antagonizes the Wnt signaling pathway. The five-membered heterocyclic amide WNT pathway inhibitor provided by the invention has a remarkable anti-tumor activity based on a target-based rational drug design of, and can be used for the development of a new generation of Wnt pathway inhibitors, and has a great clinical application value and considerable market potential.

HETEROCYCLIC COMPOUND AND p27Kip1 DEGRADATION INHIBITOR

A novel heterocyclic compound or a salt thereof useful for selectively inhibiting the degradation of p27Kip1 is provided. The compound or the salt thereof is represented by the following formula (1): wherein A represents an alkyl group, a cycloalkyl group, an aryl group or a heterocyclic group, the group A may have a substituent; the ring B represents a 5- to 8-membered monocyclic heterocyclic ring or a condensed ring containing the monocyclic heterocyclic ring, the ring B may have a substituent; the ring C represents an aromatic ring, the ring C may have a substituent; L represents a linker comprising a main chain having 3 to 5 atoms selected from the group consisting of a carbon atom, a nitrogen atom, an oxygen atom and a sulfur atom, wherein at least one atom in the main chain is a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, the linker L may have a substituent; and n is 0 or 1.

AMIDE COMPOUNDS

The present invention provides compounds represented by the formula (Ia) the formula (Ib) the formula (Ic) and the formula (Id) wherein each symbol is as defined in the specification. According to the present invention, these compounds have a DGAT inhibit