10252-51-4

Usage

Molecular Structure

1H-Pyrazole, 1-(4-nitrophenyl)-3,5-diphenylis a chemical compound with a pyrazole ring substituted with a 4-nitrophenyl group and two phenyl groups.

Versatility

The compound is highly versatile and is used in various fields such as pharmaceuticals, agrochemicals, and materials science.

Building Block

Its unique structure and properties make it a valuable building block for the synthesis of biologically active molecules and functional materials.

Pharmacological Activities

The compound has been studied for its potential pharmacological activities, including anti-cancer, anti-inflammatory, and antimicrobial properties.

Research and Development

The compound's diverse chemical and biological applications make it an important target for further research and development.

Upstream product

• 107470-32-6 1-(1,3-diphenylprop-2-yn-1-ylidene)-2-(4-nitrophenyl)hydrazine 
• 100-52-7 benzaldehyde 
• 536-74-3 phenylacetylene 
• 100-16-3 4-nitrophenylhydrazone 
• 636-98-6 p-nitrobenzene iodide 
• 108-67-8 1,3,5-trimethyl-benzene 
• 905718-45-8 [(4-nitrophenyl)(phenyl)iodonium trifluoromethanesulfonate] 
• 1145-01-3 3,5-Diphenylpyrazole 
• 1310070-02-0 (4-methoxyphenyl)(4-nitrophenyl)iodonium p-toluenesulfonate 
• 1146127-11-8 (4-nitrophenyl)(2,4,6-trimethylphenyl)iodonium trifluoromethanesulfonate 
• 532-27-4 1-chloroacetophenone 
• 98-88-4 benzoyl chloride 
• 962-13-0 N-(4-nitrophenyl)benzohydrazonoyl bromide 
• 13146-23-1 copper(I) phenylacetylenide 

Relevant academic research and scientific papers

An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes

α-Halohydrazones/ketoximes are transformed into trisubstituted pyrazoles/disubstituted isoxazoles by treatment with phosphine, acyl chloride, and a base. Mechanistic investigations revealed the in situ formation of azo/nitroso olefin intermediates which underwent a tandem phospha-Michael/N- or O-acylation/intramolecular Wittig reaction to afford the heteroarenes in moderate to good yields. Further, proper functionalization of α-haloketoximes and a change of conditions allowed the chemoselective synthesis of chromenone-oximes as well as rearranged isoxazoles, thereby realizing a diversity-oriented synthesis.

Transition-Metal-Free N-Arylation of Pyrazoles with Diaryliodonium Salts

A new synthetic method was developed for the N-arylation of pyrazoles using diaryliodonium salts. The transformation does not require any transition-metal catalyst and provides the desired N-arylpyrazoles rapidly under mild reaction condition in the presence of aqueous ammonia solution as a mild base without the use of inert atmosphere. The chemoselectivity of unsymmetric diaryliodonium salts was also explored with large number of examples.

PTSA-catalyzed Mannich-type-cyclization-oxidation tandem reactions: One-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes

A convenient one-pot Mannich-type-cyclization-oxidation tandem process has been developed for the synthesis of 1,3,5-trisubstituted pyrazoles derivatives from aldehydes, hydrazines and alkynes using p-toluenesulfonic acid monohydrate (PTSA) as a multifunctional catalyst. This method provides a flexible and rapid route to 1,3,5-trisubstituted pyrazoles.

Oxidative Cyclization of Arylhydrazones of Chalcones and Benzalacetones to Pyrazoles by Thianthrene Cation Radical

Phenyl-, (p-nitrophenyl)-, and (2,4-dinitrophenyl)hydrazones of chalcone (benzalacetophenone), benzalacetone, and of some of their derivatives undergo oxidative cyclization in reactions with thianthrene cation radical perchlorate.The products are, respect