1026902-78-2Relevant academic research and scientific papers
From five- to six-membered rings: 3,4-Diarylquinolinone as lead for novel p38MAP kinase inhibitors
Peifer, Christian,Kinkel, Katrin,Abadleh, Mohammed,Schollmeyer, Dieter,Laufer, Stefan
, p. 1213 - 1221 (2007/10/03)
In this study we describe the design, synthesis, and biological evaluation of 3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one (5) as a new inhibitor of MAPK with a p38αMAPK IC50 of 1.8 μM. By keeping the common vicinal pyridine/4-F-phenyl
