934560-46-0

Upstream product

• 462-06-6 fluorobenzene 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 118-92-3 anthranilic acid 
• 42840-02-8 2-(Toluene-4-sulfonylamino)-benzoyl chloride 
• 80-28-4 N-(2-methylphenyl)-p-toluenesulphonamide 

Downstream Products

• 3800-06-4 2-amino-4'-fluorobenzophenone 
• 1026902-78-2 N-[2-(4-fluoro-benzoyl)-phenyl]-2-pyridin-4-yl-acetamide 
• 674802-90-5 N-[2-(4-fluorobenzoyl)phenyl]-4-(methylsulfonyl)benzamide 
• 674802-91-6 4-(aminosulfonyl)-N-[2-(4-fluorobenzoyl)phenyl]benzamide 
• 154703-73-8 Trifluoro-methanesulfonic acid 2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl ester 
• 160375-37-1 2-Cyclopropyl-4-(4-fluoro-phenyl)-quinoline-3-carboxylic acid 
• 153968-97-9 2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline 
• 148516-11-4 2-cyclopropyl-4-(4-fluoro-phenyl)-3-quinoline carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthetic method for 2-amino-4'-fluoro-benzophenone

The invention discloses a synthetic method for 2-amino-4'-fluoro-benzophenone. The method comprises the following steps: subjecting o-toluidine and tosyl chloride to an amidation reaction to obtain 4-methyl-N-(2-methylphenyl) benzenesulfonamide; then performing chlorination by a chlorine gas, producing a Friedel-Crafts reaction with fluorobenzene, and obtaining N-(2-(4-fluorobenzoyl)phenyl)-4-toluenesulfonamide; and finally obtaining the 2-amino-4'-fluoro-benzophenone by deprotection of concentrated sulfuric acid. The synthetic method is cheap and easily available in starting material, is lowin cost, is convenient to operate, is suitable for industrial production, is green and environmentally friendly in synthetic route, and is high in yield, and the purity of the 2-amino-4'-fluoro-benzophenone obtained by preparation is good.

From five- to six-membered rings: 3,4-Diarylquinolinone as lead for novel p38MAP kinase inhibitors

In this study we describe the design, synthesis, and biological evaluation of 3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one (5) as a new inhibitor of MAPK with a p38αMAPK IC50 of 1.8 μM. By keeping the common vicinal pyridine/4-F-phenyl

Synthesis and biological evaluation of substituted 2-sulfonyl-phenyl-3-phenyl-indoles: A new series of selective COX-2 inhibitors

A new series of substituted 2-sulfonyphenyl-3-phenyl-indole derivatives were synthesized and evaluated for their ability to inhibit COX-2 and COX-1enzymes. Most of the compounds synthesized were found to be highly potent and selective inhibitors of COX-2. This work led to the discovery of 2-aminosulfonylphenyl-3-phenyl-indole 5a which possesses higher activity and selectivity for COX-2 than Celecoxib both in vitro and in vivo.

A NOVEL SYNTHETIC METHOD OF HMG-CoA REDUCTASE INHIBITOR NK-104 VIA HYDROBORATION-CROSS COUPLING SEQUENCE

The regioselective hydroboration of ethyl (3R,5S)-3,5-isopropylidenedioxy-6-heptynoate, followed by the cross-coupling reaction with an aryl halide, provides ethyl (3R,5S,6E)-7-aryl-3,5-isopropylidenedioxy-6-heptenoate, a precursor of a highly potent HMG-