934560-46-0

Basic information

• Product Name: N-[2-(4-fluorobenzoyl)phenyl]-4-methylbenzenesulfonamide
• Synonyms: N-[2-(4-fluorobenzoyl)phenyl]-4-methylbenzenesulfonamide
• CAS NO: 934560-46-0
• Molecular Weight: 369.416
• Mol File: 934560-46-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-[2-(4-fluorobenzoyl)phenyl]-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(4-fluorobenzoyl)phenyl]-4-methylbenzenesulfonamide(934560-46-0)
• EPA Substance Registry System: N-[2-(4-fluorobenzoyl)phenyl]-4-methylbenzenesulfonamide(934560-46-0)

Safety Data

• Hazardous Substances Data: 934560-46-0(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 462-06-6 fluorobenzene 
• 80-28-4 N-(2-methylphenyl)-p-toluenesulphonamide 
• 118-92-3 anthranilic acid 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 42840-02-8 2-(Toluene-4-sulfonylamino)-benzoyl chloride 

Downstream Products

• 154703-73-8 Trifluoro-methanesulfonic acid 2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl ester 
• 160375-37-1 2-Cyclopropyl-4-(4-fluoro-phenyl)-quinoline-3-carboxylic acid 
• 153968-97-9 2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline 
• 148516-11-4 2-cyclopropyl-4-(4-fluoro-phenyl)-3-quinoline carboxylic acid ethyl ester 
• 674802-91-6 4-(aminosulfonyl)-N-[2-(4-fluorobenzoyl)phenyl]benzamide 
• 674802-90-5 N-[2-(4-fluorobenzoyl)phenyl]-4-(methylsulfonyl)benzamide 
• 1026902-78-2 N-[2-(4-fluoro-benzoyl)-phenyl]-2-pyridin-4-yl-acetamide 
• 3800-06-4 2-amino-4'-fluorobenzophenone 

Relevant articles and documents

Synthetic method for 2-amino-4'-fluoro-benzophenone

The invention discloses a synthetic method for 2-amino-4'-fluoro-benzophenone. The method comprises the following steps: subjecting o-toluidine and tosyl chloride to an amidation reaction to obtain 4-methyl-N-(2-methylphenyl) benzenesulfonamide; then performing chlorination by a chlorine gas, producing a Friedel-Crafts reaction with fluorobenzene, and obtaining N-(2-(4-fluorobenzoyl)phenyl)-4-toluenesulfonamide; and finally obtaining the 2-amino-4'-fluoro-benzophenone by deprotection of concentrated sulfuric acid. The synthetic method is cheap and easily available in starting material, is lowin cost, is convenient to operate, is suitable for industrial production, is green and environmentally friendly in synthetic route, and is high in yield, and the purity of the 2-amino-4'-fluoro-benzophenone obtained by preparation is good.

Synthesis and biological evaluation of substituted 2-sulfonyl-phenyl-3-phenyl-indoles: A new series of selective COX-2 inhibitors

A new series of substituted 2-sulfonyphenyl-3-phenyl-indole derivatives were synthesized and evaluated for their ability to inhibit COX-2 and COX-1enzymes. Most of the compounds synthesized were found to be highly potent and selective inhibitors of COX-2. This work led to the discovery of 2-aminosulfonylphenyl-3-phenyl-indole 5a which possesses higher activity and selectivity for COX-2 than Celecoxib both in vitro and in vivo.