1027941-92-9Relevant academic research and scientific papers
Synthesis of Indolizine Derivatives by Pd-Catalyzed Oxidative Carbonylation
Xu, Tongyu,Alper, Howard
, p. 4526 - 4529 (2015)
An efficient synthesis of indolizine derivatives by palladium-catalyzed oxidative carbonylation of propargylic pyridines has been developed. The reaction can be conducted at room temperature and under 3 bar of CO in the presence of Pd2(dba)sub
Base-Controlled Cu-Catalyzed Tandem Cyclization/Alkynylation for the Synthesis of Indolizines
Oh, Kyung Hwan,Kim, Seong Min,Park, Sun Young,Park, Jin Kyoon
, p. 2204 - 2207 (2016)
A base-controlled Cu-catalyzed tandem cyclization/alkynylation of propargylic amines provides rapid access to functionalized indolizine derivatives under mild reaction conditions. The reaction first proceeded via a 5-endo-dig aminocupration, followed by a coupling between the copper-bound intermediate and alkynyl bromide, to afford the products in good to excellent yields. The successful tandem reaction is attributed to the unique property of the bases, DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) and MTBD (7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene used).
Palladium-catalyzed carbonylative cyclization/arylation cascade for 2-aroylindolizine synthesis
Li, Zhou,Chernyak, Dmitri,Gevorgyan, Vladimir
, p. 6056 - 6059 (2013/02/23)
An efficient synthesis of densely substituted 2-aroylindolizines via the palladium-catalyzed carbonylative cyclization/arylation is reported. This transformation proceeds via the 5-endo-dig cyclization of 2-propargylpyridine triggered by an aroyl Pd complex. It produced diversely substituted 2-aroylindolizines in good to excellent yields.
Two-component approach toward a fully substituted N-fused pyrrole ring
Chernyak, Dmitri,Skontos, Cathy,Gevorgyan, Vladimir
supporting information; experimental part, p. 3242 - 3245 (2010/09/30)
(Figure Presented) An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward a variety of N-fused pyrroloheterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides
Pt-catalyzed cyclization/migration of propargylic alcohols for the synthesis of 3(2H)-furanones, pyrrolones, indolizines, and indolizinones
Bunnelle, Eric M.,Smith, Cameron R.,Lee, Sharon K.,Singaram, Surendra W.,Rhodes, Allison J.,Sarpong, Richmond
, p. 7008 - 7014 (2008/09/21)
Several heterocycles such as furanones, pyrrolones, and indolizines, which are of pharmacological importance, are easily accessed via the Pt(II)-catalyzed heterocyclization/1,2-migration of propargylic ketols or hydroxy imine derivatives. This method sidesteps the challenges of traditional heteroaromatic oxygenation strategies such as regioselectivity and functional group tolerance in the syntheses of these heterocycles.
Pt-catalyzed cyclization/1,2-migration for the synthesis of indolizines, pyrrolones, and indolizinones
Smith, Cameron R.,Bunnelle, Eric M.,Rhodes, Allison J.,Sarpong, Richmond
, p. 1169 - 1171 (2007/10/03)
(Chemical Equation Presented) Indolizine, pyrrolone, and indolizinone heterocycles are easily accessed via the Pt(II)-catalyzed cycloisomerization or a tandem cyclization/ 1,2-migration of pyridine propargylic alcohols and derivatives. This method provides an efficient synthesis of highly functionalized heterocycles from readily available substrates.
