10286-76-7

Basic information

• Product Name: N1-(2,4-DICHLOROPHENYL)BENZAMIDE
• Synonyms: N1-(2,4-DICHLOROPHENYL)BENZAMIDE;N-(2,4-DICHLOROPHENYL)BENZAMIDE
• CAS NO: 10286-76-7
• Molecular Formula: C₁₃H₉Cl₂NO
• Molecular Weight: 266.12
• Mol File: 10286-76-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 300.4°Cat760mmHg
• Flash Point: 135.5°C
• Appearance: /
• Density: 1.384g/cm³
• Vapor Pressure: 0.00112mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: N1-(2,4-DICHLOROPHENYL)BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N1-(2,4-DICHLOROPHENYL)BENZAMIDE(10286-76-7)
• EPA Substance Registry System: N1-(2,4-DICHLOROPHENYL)BENZAMIDE(10286-76-7)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R36/37/38:Irritating to eyes, respiratory system
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 10286-76-7(Hazardous Substances Data)

Usage

Description

N1-(2,4-Dichlorophenyl)benzamide, a chemical compound with the molecular formula C13H9Cl2NO, is a benzamide derivative characterized by the presence of two chlorine atoms attached to a phenyl ring. N1-(2,4-DICHLOROPHENYL)BENZAMIDE holds potential in the pharmaceutical and organic synthesis industries, serving as a building block for the creation of biologically active molecules and pharmaceutical drugs. Its unique structure and properties make it a subject of interest for further research into its possible pharmacological activities.

Uses

Used in Pharmaceutical Industry:
N1-(2,4-Dichlorophenyl)benzamide is used as a building block for the synthesis of various biologically active molecules and pharmaceutical drugs. Its unique structure allows for the development of new compounds with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, N1-(2,4-Dichlorophenyl)benzamide serves as a key intermediate for the production of a range of chemical compounds. Its versatility in chemical reactions makes it a valuable component in the synthesis of various organic compounds.
Used in Research and Development:
N1-(2,4-Dichlorophenyl)benzamide is used as a subject of research for its potential pharmacological activities. Its biological effects and interactions with biological systems are of interest to scientists, who aim to explore its possible applications in medicine and drug development.

InChI:InChI=1/C13H9Cl2NO/c14-10-6-7-12(11(15)8-10)16-13(17)9-4-2-1-3-5-9/h1-8H,(H,16,17)

Upstream product

• 93-98-1 N-phenyl benzoyl amide 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 554-00-7 2,4-Dichloroaniline 
• 98-88-4 benzoyl chloride 
• 7791-25-5 sulfuryl dichloride 
• 64-19-7 acetic acid 
• 93-97-0 benzoic acid anhydride 
• 36637-30-6 O-(4-chlorophenyl)hydroxylamine 
• 99907-85-4 O-(o-chloro-phenyl)-hydroxylamine 
• 2866-82-2 N-(4-chlorophenyl)benzamide 
• 121-69-7 N,N-dimethyl-aniline 
• 100-52-7 benzaldehyde 
• 93-58-3 benzoic acid methyl ester 
• 65-85-0 benzoic acid 

Downstream Products

• 15952-20-2 6-chloro-2-phenylbenzo[d]oxazole 
• 749252-94-6 benzoic acid-(2,4,N-trichloro-anilide) 
• 97661-67-1 N-(2,4-dichloro-phenyl)-benzimidoyl chloride 

Relevant articles and documents

Copper-catalyzed synthesis of arylcarboxamides from aldehydes and isocyanides: The isocyano group as an N1 synthon

An interesting radical coupling reaction of aromatic aldehydes with isocyanides was disclosed for the synthesis of amides catalyzed by copper. According to the experimental results and mechanistic study, the isocyano group acted as an N1 synthon rather than exhibiting the carbene-like reactivity, exploiting a new reactivity profile of isocyanides.

Efficient Electrocatalysis for the Preparation of (Hetero)aryl Chlorides and Vinyl Chloride with 1,2-Dichloroethane

Although the application of 1,2-dichloroethane (DCE) as a chlorinating reagent in organic synthesis with the concomitant release of vinyl chloride as a useful byproduct is a fantastic idea, it still presents a tremendous challenge and has not yet been achieved because of the harsh dehydrochlorination conditions and the sluggish C?H chlorination process. Here we report a bifunctional electrocatalysis strategy for the catalytic dehydrochlorination of DCE at the cathode simultaneously with anodic oxidative aromatic chlorination using the released HCl as the chloride source for the efficient synthesis of value-added (hetero)aryl chlorides. The mildness and practicality of the protocol was further demonstrated by the efficient late-stage chlorination of bioactive molecules.

Amide-assisted radical strategy: Metal-free direct fluorination of arenes in aqueous media

A metal- and initiator-free direct fluorination of arenes with the assistance of an amide group is developed. This reaction proceeded under simple aqueous conditions with good functional group tolerance and ortho-para selectivity, and is highly practical because it could be readily scaled up to a multigram-scale. At this stage, an exclusive mechanism could not be proposed, and several possibilities have been discussed. The possibility of the amide-assisted radical chain mechanism has been supported by experimental and computational investigations as well as a seminal work.