10290-61-6

Basic information

• Product Name: BZ-MET-OH
• Synonyms: N-ALPHA-BENZOYL-L-METHIONINE;BZ-METHIONINE;BZ-MET-OH;BZO-MET-OH;BENZOYL-L-METHIONINE;N-benzoyl-L-methionine;Bz-L-Met-OH;(S)-2-Benzoylamino-4-(methylthio)butanoic acid
• CAS NO: 10290-61-6
• Molecular Formula: C₁₂H₁₅NO₃S
• Molecular Weight: 253.32
• EINECS: 233-646-9
• Product Categories: Amino Acids
• Mol File: 10290-61-6.mol
• Article Data: 31

Chemical Properties

• Melting Point: 176-178 °C
• Boiling Point: 529.7 °C at 760 mmHg
• Flash Point: 274.2 °C
• Appearance: /
• Density: 1.237 g/cm³
• Vapor Pressure: 4.75E-12mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: Store at RT.
• PKA: 3.66±0.10(Predicted)
• CAS DataBase Reference: BZ-MET-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BZ-MET-OH(10290-61-6)
• EPA Substance Registry System: BZ-MET-OH(10290-61-6)

Safety Data

• Hazardous Substances Data: 10290-61-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C12H15NO3S/c1-17-8-7-10(12(15)16)13-11(14)9-5-3-2-4-6-9/h2-6,10H,7-8H2,1H3,(H,13,14)(H,15,16)

Upstream product

• 63-68-3 L-methionine 
• 98-88-4 benzoyl chloride 
• 7200-20-6 N-benzoyl-DL-methionine ethyl ester 
• 23405-15-4 benzoic acid N-hydroxysuccinimide ester 
• 50732-06-4 methyl benzoyl-L-methioninate 
• 4703-38-2 N-benzoylmethionine 
• 65-85-0 benzoic acid 
• 132353-23-2 2-(benzyloxy)-4,6-dimethoxy-1,3,5-triazin 
• 59-51-8 DL-methionine 
• 51127-20-9 4-(2-methylsulfanyl-ethyl)-2-phenyl-4H-oxazol-5-one 
• 7732-18-5 water 
• 62-53-3 aniline 
• 58156-44-8 2,4,6-trinitrophenyl benzoate 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 348-67-4 D-methionine 
• 63-68-3 L-methionine 
• 4703-38-2 (R)-N-benzoylmethionine 
• 94067-89-7 N-benzoyl-L-methionine anilide 
• 7200-20-6 N-benzoyl-DL-methionine ethyl ester 
• 5468-52-0 N-benzoyl-2-aminobutyric acid 
• 59-51-8 DL-methionine 
• 1208867-91-7 C₃₃H₂₉NO₃S 
• 51127-20-9 4-(2-methylsulfanyl-ethyl)-2-phenyl-4H-oxazol-5-one 
• 1626437-63-5 1-benzoyl-5-(2-(methylthio)ethyl)pyrrolidine-2,4-dione 
• 3054-52-2 2-benzamido-4-(methylsulfinyl)butyric acid 
• 71963-73-0 C₁₂H₁₃NO₂S 

Relevant articles and documents

Studies on acylase activity and micro-organisms. XIX. Optical resolution of threonine. lvsine. trvptophan. and methionine by ucylase of soil bacteria.

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Asymmetric Aza-Diels-Alder Reactions of in Situ Generated β,β-Disubstituted α,β-Unsaturated N-H Ketimines Catalyzed by Chiral Phosphoric Acids

A novel asymmetric synthesis of dihydropyridinones with vicinal quaternary stereocenters has been realized by asymmetric aza-Diels-Alder reactions of 3-amido allylic alcohols with oxazolones enabled by chiral phosphoric acid catalysis. A series of aryl/alkyl- and alkyl/alkyl-disubstituted 3-amido allylic tertiary alcohols and 4-substituted oxazolones could be well tolerated in these reactions, producing dihydropyridinones with excellent diastereoselectivities and high enantioselectivities. Mechanistic study and control experiments were performed to shed light on the reaction mechanism, in which a configurationally defined β,β-disubstituted α,β-unsaturated N-H ketimine was proposed as the key intermediate.

Asymmetric construction of dihydrobenzofuran-2,5-dione derivatives via desymmetrization of p-quinols with azlactones

The desymmetrization of p-quinols through a chiral bisguanidinium hemisalt catalyzed enantioselective Michael addition/lactonization cascade reaction with azlactones was reported. 3-Amino-benzofuran-2,5-diones containing a chiral amino acid residue were achieved with up to 99% ee and >19?:?1 dr. An exploration of the structure of the catalyst bisguanidinium was undertaken, revealing a bifunctional catalytic model.