102919-85-7

Usage

Chemical Properties

Beige Solid

Uses

Opioid receptor antagonist.

Upstream product

• 16590-41-3 Naltrexone 
• 144-55-8 sodium hydrogencarbonate 
• 16676-29-2 naltrexone Hydrochloride 
• 74-89-5 methylamine 
• 593-51-1 methylamine hydrochloride 
• 75768-72-8 naltrexone hydrochloride 

Downstream Products

• 1204239-42-8 6-α-(4'-trifluoromethyl)-N-methylbenzamido-14-hydroxy-17-(cyclopropylmethyl)nordesmorphine 
• 1204239-43-9 6-α-(4'-bromo)-N-methylbenzamido-14-hydroxy-17-(cyclopropylmethyl)nordesmorphine 
• 152657-12-0 N-[(5R,6S)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-2-(3,4-dichlorophenyl)-N-methylacetamide hydrochloride 

Relevant academic research and scientific papers

NOVEL MORPHINANS USEFUL FOR TREATING MEDICAL DISORDERS

The present invention related to novel morphinans, compositions comprising the novel morphinans, and their uses as agonists of the kappa opioid receptor.

Preparation of 6-Alpha-Amino N-Substituted Morphinans by Catalytic Hydrogen Transfer

The present invention provides processes for the stereoselective synthesis of 6-alpha-amino N-substituted morphinans. In particular, the invention provides processes for the reductive amination of 6-keto N-substituted morphinans by catalytic hydrogen transfer.

SYNTHESIS OF METABOLICALLY STABLE AGENTS FOR ALCOHOL AND DRUG ABUSE

Disclosed herein are compounds of formula (I); as defined herein, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same, and methods of using these compounds for the treatment of substance addiction.

Morphinan derivatives and pharmaceutical use thereof

A morphinan derivative or its pharmaceutically acceptable acid addition salt represented with, for example, and an analgesic, diuretic, antitussive and brain cell protector having its derivative or its salt as the active ingredient are described. The compound of the present invention possesses strong analgesic activity, diuretic action and antitussive action as a highly selective κ-opioid agonist, allowing it to be used as a useful analgesic, diuretic and antitussive. On the other hand, the compound of the present invention also possesses remarkable cerebro-neuroprotective activity, thus allowing it be used as a useful cerebro-neuroprotective agents.

Morphinan derivative and its pharmaceutical applications

A morphinan derivative or its pharmacologically allowed acid addition salt represented with compound I, an analgesic and diuretic having its derivative or its salt as the active ingredient, and its production process are described. The compound of the present invention possesses strong analgesic activity and diuretic action as a highly selective κ-opioid agonist, allowing it to be used as a useful analgesic and diuretic.

Brain cell protective agent

The present invention relates to a novel brain cell protective agent having for its active ingredient a morphinan derivative represented with Compound 1 STR1 or pharmacologically acceptable acid addition salt thereof. The compounds used in the present inv