10292-60-1

Basic information

• Product Name: Phenol, 2-cyclopropyl-
• Synonyms: AKOS BAR-1540;2-CYCLOPROPYLPHENOL;Phenol, 2-cyclopropyl-;2-Cyclopropylphenol 98%;(2-Hydroxyphenyl)cyclopropane
• CAS NO: 10292-60-1
• Molecular Formula: C₉H₁₀O
• Molecular Weight: 134.18
• Product Categories: Aromatics, Intermediates
• Mol File: 10292-60-1.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 169.8±9.0 °C(Predicted)
• Appearance: /
• Density: 1.158±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.31±0.30(Predicted)
• CAS DataBase Reference: Phenol, 2-cyclopropyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-cyclopropyl-(10292-60-1)
• EPA Substance Registry System: Phenol, 2-cyclopropyl-(10292-60-1)

Safety Data

• Hazardous Substances Data: 10292-60-1(Hazardous Substances Data)

Usage

Uses

2-Cyclopropyl-phenol is a reagent used to prepare imidazolines which display significant adrenergic α2C-Agonism/α2A-Antagonism. It is also an intermediate used in preparation of Cirazoline Hydrochloride (C497400) which is a potent α-1 adrenergic receptor agonist and an even more potent α-2 receptor antagonist.

Upstream product

• 3158-73-4 2-cyclopropylaniline 
• 28987-74-8 (RS)-6-acetoxy-6-cyclopropylcyclohexa-2,4-dien-1-one 
• 198201-73-9 (2-Cyclopropyl-phenoxy)-trimethyl-silane 
• 1745-81-9 o-Allylphenol 
• 60333-75-7 O-allyl-2-bromophenol 
• 873-49-4 cyclopropylbenzene 
• 882-33-7 diphenyldisulfane 
• 65006-97-5 [(1-chlorocyclopropyl)sulfinyl]benzene 
• 108-95-2 phenol 
• 77-76-9 2,2-dimethoxy-propane 
• 470693-88-0 3-cyclopropylcyclohexa-3,5-diene-1,2-diol 
• 555-24-8 lithium phenolate 
• 24892-63-5 1-allyloxy-2-iodobenzene 
• 138142-60-6 Trimethyl(2-vinylphenoxy)silane 

Downstream Products

• 1043871-14-2 4-bromo-2-cyclopropylphenol 
• 60319-06-4 1,1,2,2,3,3,4,4,4-Nonafluoro-butane-1-sulfonic acid 2-cyclopropyl-phenyl ester 
• 1197813-10-7 2-(2-cyclopropylphenoxy)propionic acid methyl ester 
• 1062617-20-2 1,2-bis(3-cyclopropyl-4-(difluoromethoxy)phenyl)ethane-1,2-dione 
• 1062617-16-6 1,2-bis(3-cyclopropyl-4-(difluoromethoxy)phenyl)ethyne 
• 1062617-13-3 4-bromo-2-cyclopropyl-1-(difluoromethoxy)benzene 
• 1602681-28-6 6-(2-cyclopropylphenoxy)-4-(6-methylpyridin-2-ylamino)pyridazine-3-carboxamide 
• 749929-58-6 4-Bromo-2-cyclopropyl-1-methoxy-benzene 
• 1253420-71-1 (S)-(+)-2-(1-(2-cyclopropylphenoxy)ethyl)-4,5-dihydro-1H-imidazole 
• 1253420-67-5 (S)-(-)-methyl-2-(2-cyclopropylphenoxy)propanoate 
• 1253420-72-2 (R)-(-)-2-(1-(2-cyclopropylphenoxy)ethyl)-4,5-dihydro-1H-imidazole 
• 1253420-68-6 (R)-(+)-methyl 2-(2-cyclopropylphenoxy)propanoate 
• 1201927-64-1 C₂₀H₂₄N₂O 
• 499234-73-0 3-chloro-6-(2-cyclopropylphenoxy)-pyridazine 1-oxide 

Relevant articles and documents

Novel photohydration of non-conjugated aryl/olefin bichromophores within cyclodextrin cavities

Cyclodextrin media are used to achieve photochemical water addition to isolated, acyclic double bonds via intramolecular interaction with excited arenes.

Isomerization of 2-(2-propenoxy)phenyllithium: Tandem anionic cyclization-γ-elimination

2-(2-Propenoxy)phenyllithium (1), which may be prepared from the corresponding iodide by low-temperature lithium-iodine exchange, rearranges on warming in the presence of TMEDA via 5-exo cyclization to (2,3-dihydrobenzofuranyl)methyllithium (2) followed by γ-elimination to give variable amounts of the lithium salt of 2-(cyclopropyl)phenol (3).

Diastereo- and enantioselective carbolithiation of allyl o-lithioaryl ethers. New chiral cyclopropane derivatives

(matrix presented) Different allyl 2-lithioaryl ethers undergo a tandem carbolithiation/γ-elimination in Et2OH-MEDA affording o-cyclopropyl phenol or naphthol derivatives in a diastereoselective manner. The use of (-)-sparteine as a chiral liga

Explorations of [4+2] and [5+2] cycloadditions of dienylcyclopropane derived enzymatically from cyclopropylbenzene

Fermentation of cyclopropylbenzene with E. coli JM109(pDTG601a) furnished optically pure 1-cyclopropyl-2,3-dihydroxycyclohexa-4,6-diene whose reactivity in [4+2]- and [5+2]-cycloaddition chemistry was explored. Georg Thieme Verlag Stuttgart. New York.

NEW COMPOUNDS 574

The present invention relates to novel compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Downs syndrome,