1132832-75-7

Basic information

• Product Name: (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone
• Synonyms: (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone;2-(5-BroMo-2-Methylbenzoyl)-5-(4-fluorophenyl)thiophene;(5-broMo-2-Methylphenyl)[5-(4-fluorophenyl)-2-thienyl]- Methanone;Methanone, (5-BroMo-2-Methylphenyl)[5-(4-fluorophenyl)-2-thienyl]-;Canagliflozin iMpurity B;Canagliflozin INT1;(5-bromo-2-methylphenyl)[5-(4-flurophenyl)-2-thienyl]-methanone
• CAS NO: 1132832-75-7
• Molecular Formula: C₁₈H₁₂BrFOS
• Molecular Weight: 375.2546832
• EINECS: 1308068-626-2
• Mol File: 1132832-75-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 476.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.448±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMSO (Slightly)
• CAS DataBase Reference: (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone(1132832-75-7)
• EPA Substance Registry System: (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone(1132832-75-7)

Safety Data

• Hazardous Substances Data: 1132832-75-7(Hazardous Substances Data)

Usage

Uses

2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thiophene is an intermediate in the preparation of Canagliflozin which is a sodium-dependent glucose co-transporter 2 inhibitor used in the treatment of type 2 diabetes.

Synthetic route

2-(4-fluorophenyl)thiophene (58861-48-6) + 5-bromo-2-methylbenzoic acid (79669-49-1) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Conditions	Yield
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 20 - 25℃; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 25℃; for 12.5h; Solvent; Reagent/catalyst;	93.2%
Stage #1: 5-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 35℃;	89%
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 25 - 30℃; for 0.1h; Inert atmosphere; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at 0 - 15℃; Inert atmosphere;	80.4%
Stage #1: 5-bromo-2-methylbenzoic acid With oxalyl dichloride In dichloromethane at 20℃; for 2h; Stage #2: 2-(4-fluorophenyl)thiophene With aluminum (III) chloride In dichloromethane at -15 - 35℃; for 4h;	80%

2-(4-fluorophenyl)thiophene (58861-48-6) + 5-bromo-2-methylbenzoyl chloride (21900-41-4) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Conditions	Yield
With aluminum (III) chloride In dichloromethane at -10 - 25℃; for 5.5h; Friedel-Crafts Acylation; Inert atmosphere;	90.1%
With aluminum (III) chloride In dichloromethane at 0 - 20℃; Friedel Crafts acylation;	85.7%
Stage #1: 2-(4-fluorophenyl)thiophene; 5-bromo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at -10 - 20℃; for 2.5 - 3.5h; Stage #2: With hydrogenchloride; water In n-heptane; dichloromethane at -12℃;
Stage #1: 2-(4-fluorophenyl)thiophene; 5-bromo-2-methylbenzoyl chloride With aluminum (III) chloride In dichloromethane at 0 - 20℃; Stage #2: With water In tetrahydrofuran cooling with ice;

1-Bromo-4-fluorobenzene (460-00-4) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium carbonate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / ethanol; water / 90 °C / Inert atmosphere 2.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C 2.2: cooling with ice View Scheme
Multi-step reaction with 4 steps 1: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 22 h / 140 - 150 °C 2: sodium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / acetonitrile; water / 1.5 h / 40 °C 3: thionyl chloride / toluene / 21 h / 90 °C 4: iron(III) chloride / dichloromethane / 20 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1.1: potassium propionate; bis[di-t-butyl(p-dimethylaminophenyl)phosphino]palladium (II) Dichloride / Isopropyl acetate / Reflux 2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / Dimethyl ether; water / 70 - 75 °C 3.1: thionyl chloride / N,N-dimethyl-formamide; dichloromethane / 0 - 35 °C 3.2: 0 - 35 °C View Scheme

5-bromo-2-methylbenzoic acid (79669-49-1) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 6 h / 20 °C 2.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C 2.2: cooling with ice View Scheme
Multi-step reaction with 2 steps 1.1: dicyclohexyl-carbodiimide; 1-hydroxybenzotriazol-hydrate; triethylamine / dichloromethane / 20 °C / Inert atmosphere 2.1: hydrogenchloride; magnesium; iodine / diethyl ether / 0.33 h / Inert atmosphere; Reflux 2.2: 20 °C / Inert atmosphere View Scheme

5-(4-fluorophenyl)thiophene-2-carboxylic acid (115933-30-7) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: thionyl chloride / toluene / 21 h / 90 °C 2: iron(III) chloride / dichloromethane / 20 h / 20 °C View Scheme

5-(4-fluorophenyl)thiophene-2-carbonyl chloride (918487-45-3) + para-bromotoluene (106-38-7) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Conditions	Yield
With iron(III) chloride In dichloromethane at 20℃; for 20h;	0.77 g

thiophene-2-carbaldehyde (98-03-3) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 22 h / 140 - 150 °C 2: sodium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / acetonitrile; water / 1.5 h / 40 °C 3: thionyl chloride / toluene / 21 h / 90 °C 4: iron(III) chloride / dichloromethane / 20 h / 20 °C View Scheme

5-(4-fluorophenyl)thiophene-2-carboxaldehyde (249504-38-9) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / acetonitrile; water / 1.5 h / 40 °C 2: thionyl chloride / toluene / 21 h / 90 °C 3: iron(III) chloride / dichloromethane / 20 h / 20 °C View Scheme

4-fluoroboronic acid (1765-93-1) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 25 - 75 °C / Inert atmosphere 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.1 h / 25 - 30 °C / Inert atmosphere 2.2: 0 - 15 °C / Inert atmosphere View Scheme

2-bromo-5-(4-fluorophenyl)thiophene (1073313-97-9) + 5-bromo-N-methoxy-N,2-dimethylbenzamide (842135-03-9) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Conditions	Yield
Stage #1: 2-bromo-5-(4-fluorophenyl)thiophene With hydrogenchloride; iodine; magnesium In diethyl ether for 0.333333h; Inert atmosphere; Reflux; Stage #2: 5-bromo-N-methoxy-N,2-dimethylbenzamide In tetrahydrofuran; diethyl ether at 20℃; Inert atmosphere;	0.402 g

fluorobenzene (462-06-6) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / dichloromethane / 2 h / Cooling with ice; Reflux 2.1: tetraphosphorus decasulfide / toluene / 0.5 h / Microwave irradiation 3.1: oxalyl dichloride / dichloromethane / 2 h / 20 °C 3.2: 4 h / -15 - 35 °C View Scheme

4-(4-fluorophenyl)-4-oxopropionic acid (366-77-8) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: tetraphosphorus decasulfide / toluene / 0.5 h / Microwave irradiation 2.1: oxalyl dichloride / dichloromethane / 2 h / 20 °C 2.2: 4 h / -15 - 35 °C View Scheme

2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (214360-58-4) → (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / Dimethyl ether; water / 70 - 75 °C 2.1: thionyl chloride / N,N-dimethyl-formamide; dichloromethane / 0 - 35 °C 2.2: 0 - 35 °C View Scheme

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → 2-[(5-bromo-2-methyl-phenyl)methyl]-5-(4-fluorophenyl)thiophene (1030825-20-7)

Conditions	Yield
With borane-THF In tetrahydrofuran at -20 - -10℃; for 48h; Reagent/catalyst; Temperature; Concentration; Solvent;	97.7%
With hydrogen In isopropyl alcohol at 100℃; under 22502.3 Torr; for 5h; Reagent/catalyst; Temperature; Pressure; Autoclave;	97%
Stage #1: (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone With aluminum (III) chloride In tetrahydrofuran at 0 - 5℃; for 0.5h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran Reflux;	92%

methanesulfonic acid (75-75-2) + (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) + C14H18O10 → C33H33FO11S

Conditions	Yield
Stage #1: (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone With n-butyllithium In tetrahydrofuran; N,N-dimethyl-formamide at -50 - -40℃; for 3h; Inert atmosphere; Stage #2: C14H18O10 In tetrahydrofuran; N,N-dimethyl-formamide for 8h; Inert atmosphere; Stage #3: methanesulfonic acid In tetrahydrofuran at 20℃;	85.8%

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → (5-bromo-2-[D3]methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)ketone

Conditions	Yield
With [D]-sodium hydroxide In water-d2 at 160℃; for 8h;	84%

methanesulfonic acid (75-75-2) + (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) + C10H18O14S4 → C29H33FO15S5

Conditions	Yield
Stage #1: (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone With potassium hexamethylsilazane In tetrahydrofuran; toluene at -50 - -40℃; for 3h; Inert atmosphere; Stage #2: C10H18O14S4 In tetrahydrofuran; toluene for 8h; Inert atmosphere; Stage #3: methanesulfonic acid In tetrahydrofuran at 20℃;	83.9%

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → 2-(5-bromo-2-methyl[1,1-D2]benzyl)-5-(4-fluorophenyl)thiophene

Conditions	Yield
With aluminum (III) chloride; sodium borodeuteride In acetonitrile at 55℃; for 0.166667h; Inert atmosphere;	82%

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → (1R,4R,5S,6R)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)-1-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)cyclohex-2-enol (1413373-77-9)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane; acetonitrile / 3 h / 0 - 20 °C 2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 0.08 h / -70 °C / Inert atmosphere 2.2: 0.25 h / -70 °C View Scheme

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → (3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol (1030825-21-8)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride; sodium tetrahydroborate / 1,2-dimethoxyethane / 0 - 70 °C 2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere 2.2: -75 - -70 °C 2.3: 12 h / -75 - 30 °C View Scheme

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → canagliflozin (842133-18-0)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride; sodium tetrahydroborate / 1,2-dimethoxyethane / 0 - 70 °C 2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere 2.2: -75 - -70 °C 2.3: 12 h / -75 - 30 °C 3.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 0 - 5 °C View Scheme
Multi-step reaction with 4 steps 1.1: 0.25 h / 20 °C 1.2: 50 - 60 °C 2.1: iodine; magnesium / tetrahydrofuran / 25 - 35 °C / Inert atmosphere 2.2: 2 h / 0 - 5 °C / Inert atmosphere 3.1: methanesulfonic acid / water / 20 °C 4.1: triethylsilane / acetonitrile; dichloromethane / 0.25 h / 0 - 5 °C / Inert atmosphere 4.2: 0 - 30 °C / Inert atmosphere View Scheme

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate (866607-35-4)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: aluminum (III) chloride; sodium tetrahydroborate / 1,2-dimethoxyethane / 0 - 70 °C 2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere 2.2: -75 - -70 °C 2.3: 12 h / -75 - 30 °C 3.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 0 - 5 °C 4.1: dmap / acetone / 5 h / 0.25 - 0.5 °C View Scheme

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → (2S,3R,4R,5S,6R)-2-3-((5-(4-fluorophenyl)thiophen-[1,1-D2]methyl)-4-methylphenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyrantriol

Conditions	Yield
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride; sodium borodeuteride / acetonitrile / 0.17 h / 55 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; toluene / 0.55 h / -78 - -66 °C / Inert atmosphere 2.2: 5 h / -78 - -60 °C 3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / -50 - 20 °C View Scheme

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → (3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)[1,1-D2]methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Conditions	Yield
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride; sodium borodeuteride / acetonitrile / 0.17 h / 55 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; toluene / 0.55 h / -78 - -66 °C / Inert atmosphere 2.2: 5 h / -78 - -60 °C View Scheme

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → 2-(5-bromo-2-[D3]methylbenzyl)-5-(4-fluorophenyl)thiophene

Conditions	Yield
Multi-step reaction with 2 steps 1: [D]-sodium hydroxide / water-d2 / 8 h / 160 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 55 °C / Inert atmosphere View Scheme

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) + trimethyl orthoformate (149-73-5) → 2-[(5-bromo-2-methylphenyl)(dimethoxy)methyl]-5-(4-fluorophenyl)thiophene

Conditions	Yield
Stage #1: (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone; trimethyl orthoformate at 20℃; for 0.25h; Stage #2: With toluene-4-sulfonic acid In methanol at 50 - 60℃;

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → [5-(4-fluorophenyl)-thiophen-2-yl]-[2-methyl-5-(3,4,5-trihydroxy-6-hydroxymethyl-2-methoxy-tetrahydropyran-2-yl)-phenyl]methanone

Conditions	Yield
Multi-step reaction with 3 steps 1.1: 0.25 h / 20 °C 1.2: 50 - 60 °C 2.1: iodine; magnesium / tetrahydrofuran / 25 - 35 °C / Inert atmosphere 2.2: 2 h / 0 - 5 °C / Inert atmosphere 3.1: methanesulfonic acid / water / 20 °C View Scheme

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → C32H33FO9S

Conditions	Yield
Multi-step reaction with 2 steps 1.1: n-butyllithium / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / -50 - -40 °C / Inert atmosphere 1.2: 8 h / Inert atmosphere 1.3: 20 °C 2.1: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran; methanol / 25 - 60 °C 2.2: Inert atmosphere View Scheme

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]glucitol

Conditions	Yield
Multi-step reaction with 3 steps 1.1: n-butyllithium / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / -50 - -40 °C / Inert atmosphere 1.2: 8 h / Inert atmosphere 1.3: 20 °C 2.1: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran; methanol / 25 - 60 °C 2.2: Inert atmosphere 3.1: lithium hydroxide; water / methanol / 20 °C View Scheme
Multi-step reaction with 3 steps 1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 3 h / -50 - -40 °C / Inert atmosphere 1.2: 8 h / Inert atmosphere 1.3: 20 °C 2.1: lithium borohydride; aluminum (III) chloride / tetrahydrofuran; methanol / 25 - 60 °C 2.2: -30 - 20 °C / Inert atmosphere 3.1: sodium hydroxide; water / tetrahydrofuran / 20 °C View Scheme

(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone (1132832-75-7) → C28H33FO13S5

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 3 h / -50 - -40 °C / Inert atmosphere 1.2: 8 h / Inert atmosphere 1.3: 20 °C 2.1: lithium borohydride; aluminum (III) chloride / tetrahydrofuran; methanol / 25 - 60 °C 2.2: -30 - 20 °C / Inert atmosphere View Scheme

Upstream product

• 115933-30-7 5-(4-fluorophenyl)thiophene-2-carboxylic acid 
• 918487-45-3 5-(4-fluorophenyl)thiophene-2-carbonyl chloride 
• 106-38-7 para-bromotoluene 
• 98-03-3 thiophene-2-carbaldehyde 
• 249504-38-9 5-(4-fluorophenyl)thiophene-2-carboxaldehyde 
• 214360-58-4 2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 366-77-8 4-(4-fluorophenyl)-4-oxopropionic acid 
• 462-06-6 fluorobenzene 
• 1073313-97-9 2-bromo-5-(4-fluorophenyl)thiophene 
• 842135-03-9 5-bromo-N-methoxy-N,2-dimethylbenzamide 
• 58861-48-6 2-(4-fluorophenyl)thiophene 
• 79669-49-1 5-bromo-2-methylbenzoic acid 
• 1765-93-1 4-fluoroboronic acid 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 1030825-20-7 3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide 
• 1413373-77-9 (1R,4R,5S,6R)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)-1-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)cyclohex-2-enol 
• 1030825-21-8 methyl 1-C-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methyl-phenyl)-D-glucopyranoside 
• 842133-18-0 canagliflozin 
• 866607-35-4 (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1589590-87-3 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]glucitol 

Relevant articles and documents

Preparation method of 2-(4-fluorophenyl)-5-[(5-bromo-2-methylphenyl)methyl]thiophene

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