103094-30-0

Basic information

• Product Name: 3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: 4-92-ChloroPhenyl)-3-EthoxyCarbonyl-5-MethoxyCarbonyl-6-Methyl-2-(2-PhthalimidoEthoxy)Methyl-1,4-DihydroPyridine,AmlodipineBesylate;4-(2-Chloro Phenyl)-3-Ethoxycarbonyl-5-Methoxy carbonyl-6-Methyl-2-(2-Phthalimido Ethoxy) Methyl-1,4-Dihydro Pyridine;3-ETHYL-5-METHYL-4-(2-CHLOROPHENYL)-2-(2,2-DIETHOXY-ETHOXYMETHYL)-6-METHYL-1,4-DIHYDRO-PYRIDINE-3,5-DICARBOXYLATE;3-ETHYL-5-METHYL-4-(2-CHLOROPHENYL)-2-(2,2-DIETHOXY-ETHOXYMETHYL)-6-METHYL-1,4-DIHYDRO-PYRIDINE-3,5-DIDARBOXYLATE;3-Ethyl-5-methyl-4-(2-Chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-Methyl-1,4-Dihydro-Pyridine-3,5-Didarboxylate;3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS NO: 103094-30-0
• Molecular Formula: C24H32ClNO7
• Molecular Weight: 481.96638
• Mol File: 103094-30-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 553.084 °C at 760 mmHg
• Flash Point: 288.295 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: 3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate(103094-30-0)
• EPA Substance Registry System: 3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate(103094-30-0)

Safety Data

• Hazardous Substances Data: 103094-30-0(Hazardous Substances Data)

Usage

General Description

The chemical 3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2,2-diethoxy-ethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate is a complex compound with a dihydropyridine structure. It contains an ethyl and methyl group, as well as a 2-chlorophenyl moiety. Additionally, it has a diethoxy-ethoxymethyl group attached to the dihydropyridine ring. This chemical is often used as a calcium channel blocker, and it has potential applications in the treatment of hypertension, angina pectoris, and other cardiovascular conditions. Its unique structure and pharmacological properties make it a valuable compound for pharmaceutical research and drug development.

InChI:InChI=1/C24H32ClNO7/c1-6-31-19(32-7-2)14-30-13-18-22(24(28)33-8-3)21(16-11-9-10-12-17(16)25)20(15(4)26-18)23(27)29-5/h9-12,19,21,26H,6-8,13-14H2,1-5H3

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 21731-17-9 methyl 3-aminocrotonate 
• 88150-75-8 ethyl 4-[2-(phthalimido)ethoxy]acetoacetate 
• 14205-39-1 methyl 3-aminocrotonate 
• 67593-46-8 methyl (Z)-2-acetyl-3-(2-chlorophenyl)acrylate 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 14205-39-1 methyl (E)-3-aminocrotonate 
• 13176-46-0 4-bromoethyl acetoacetate 
• 1074-82-4 potassium phtalimide 
• 400024-08-0 ethyl 2-(2-chlorobenzylidene)-4-[(2-phthalimido)ethoxy]acetoacetate 
• 85-44-9 phthalic anhydride 
• 265136-65-0 ethyl (E)-3-amino-4-[2-(phthalimido)ethoxy]crotonate 

Downstream Products

• 93849-02-6 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 

Relevant articles and documents

Method for preparing amlodipine besylate intermediate by using micro-reaction device

The invention provides a method for producing an amlodipine besylate intermediate by using a micro-reaction device. According to the method, o-chlorobenzaldehyde is used as a raw material, the amlodipine besylate intermediate is rapidly and safely prepared by using the micro-reaction device, and the method has the advantages of high reaction conversion rate, simple post-treatment, small reaction volume, short reaction time, low energy consumption and the like, and has relatively high commercial value.

Synthesis technology of amlodipine maleate

The invention discloses a synthesis technology of amlodipine maleate and relates to the technical field of medicine synthesis, aiming at solving the problem in an existing synthesis technology that more byproducts and impurities exist in industrial production. By controlling parameters of the synthesis technology and reducing the content of the impurities, the purity of the prepared amlodipine maleate reaches 99.5 percent; the self-made amlodipine maleate is used as a raw material for further preparing the amlodipine maleate, so that the cost of a product is reduced and the quality controllability of the product is strong.

Using the new crystal form [...] and production of high-purity [...]

PROBLEM TO BE SOLVED: To provide a process for producing high-purity phthaloyl amlodipine for synthesis of an amlodipine besilate having excellent purity as a medicine.SOLUTION: Provided are TW-A type and TW-B type crystal forms of highly pure phthaloyl amlodipine. In powder X-ray diffraction, the TW-A type phthaloyl amlodipine has diffraction peaks at 2θ(°)=8.7±0.2, 11.0±0.2, 13.4±0.2, 15.7±0.2, and 24.6±0.2. In powder X-ray diffraction, the TW-B type phthaloyl amlodipine has diffraction peaks at 2θ(°)=6.6±0.2, 9.9±0.2, 11.1±0.2, 17.3±0.2, and 24.4±0.2.