1031721-43-3 Usage
General Description
2-(6-(trifluoromethyl)pyridin-3-yl)propan-2-ol, also known as TFP, is a chemical compound with the molecular formula C11H12F3NO. It is a derivative of pyridine, containing a trifluoromethyl group and a propan-2-ol moiety. TFP is commonly used in pharmaceutical research and drug development as a building block in the synthesis of various biologically active compounds. It has also been used as a reagent in organic synthesis and as a ligand in coordination chemistry. TFP possesses unique chemical and biological properties, making it a valuable tool in the design and synthesis of potential drug candidates. Additionally, its fluorinated structure makes it useful in the study of fluorine-containing compounds and their interactions in biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 1031721-43-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,1,7,2 and 1 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1031721-43:
(9*1)+(8*0)+(7*3)+(6*1)+(5*7)+(4*2)+(3*1)+(2*4)+(1*3)=93
93 % 10 = 3
So 1031721-43-3 is a valid CAS Registry Number.
1031721-43-3Relevant articles and documents
Convergent asymmetric synthesis of two complex TRPV1 antagonists
Butcher, Kenneth J.,Denton, Steven M.,Field, Stuart E.,Gillmore, Adam T.,Harbottle, Gareth W.,Howard, Roger M.,Laity, Daniel A.,Ngono, Christian J.,Pibworth, Benjamin A.
, p. 1192 - 1200 (2011/12/16)
The convergent scale-up synthesis of two complex TRPV1 antagonists to support exploratory toxicology studies is described. Both compounds contain three chiral centers introduced by asymmetric synthesis with chiral control being critical for the success of the project. Preparation of the key cyclopropyl intermediate utilised an asymmetric cyclopropanation using thermally unstable ethyl diazoacetate. Ellman's auxiliary was used to synthesize the chiral α-methyl benzylamine fragments. This paper highlights some of the key synthetic challenges, processing issues, and safety aspects from the scale-up of this chemistry.
