103186-19-2

Basic information

• Product Name: BRONICA
• CAS NO: 103186-19-2
• Molecular Formula: C22H26O4
• Molecular Weight: 354.43944
• Mol File: 103186-19-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BRONICA(CAS DataBase Reference)
• NIST Chemistry Reference: BRONICA(103186-19-2)
• EPA Substance Registry System: BRONICA(103186-19-2)

Safety Data

• Hazardous Substances Data: 103186-19-2(Hazardous Substances Data)

Usage

Uses

Anti-asthmatic (thromboxane receptor antagonist); anti-inflammatory (nonantihistaminic).

Upstream product

• 148989-82-6 7-(2-hydroxy-3,4,6-trimethylphenyl)-7-phenylheptanoic acid 
• 935-92-2 2,3,5-Trimethyl-1,4-benzoquinone 
• 108-86-1 bromobenzene 
• 103187-18-4 7-hydroxy-7-phenylheptanoic acid 
• 112665-42-6 7-hydroxy-7-phenyl-heptanoic acid ethyl ester 
• 112665-41-5 ethyl 7-oxo-7-phenylheptanoate 
• 33018-91-6 7-ethoxy-7-oxoheptanoic acid 
• 14794-32-2 ethyl 6-(chloroformyl)hexanoate 
• 148989-73-5 7-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-7-phenyl-heptanoic acid 
• 14996-78-2 2-phenylcycloheptanone 
• 92035-59-1 2-phenylcycloheptan-1-ol 
• 25308-75-2 1-Phenylcycloheptene 
• 502-42-1 cycloheptanone 
• 4537-09-1 1,4-dimethoxy-2,3,5-trimethyl-benzene 

Relevant articles and documents

Catalytic Redox Chain Ring Opening of Lactones with Quinones to Synthesize Quinone-Containing Carboxylic Acids

Catalytic ring opening of five- to eight-membered lactones with quinones is achieved through a redox chain mechanism. With low loading of a simple metal triflate Lewis acid catalyst and a chain initiator, C-H bonds of many quinones were efficiently functionalized with carboxylic acid-containing side chains. This method also features 100% atom economy and wide substrate scope. A novel route to the anti-asthma drug Seratrodast was developed. Mechanism study suggests that the redox chain reaction likely undergoes a carbocation intermediate.

Indium-catalyzed synthesis of keto esters from cyclic 1,3-diketones and alcohols and application to the synthesis of seratrodast

Esterification reactions from cyclic 1,3-diketones and alcohols are carried out in the presence of several Lewis acids. In particular, indium(III) triflate, In(OTf)3, iron(III) triflate, Fe-(OTf)3, copper(II) triflate, Cu(OTf)2, and silver(I) triflate, AgOTf, show high catalytic activities. These reactions proceed through the carbon-carbon bond cleavage by a retro-aldol reaction and were found to be highly regioselective even in the presence of other functional groups. This type of reaction can also be applied to the preparation of the keto esters during the synthesis of seratrodast, which is an antiasthmatic and eicosanoid antagonist.

Process for preparing diphenylmethane compounds

A diphenylmethane compound (III) can be produced in a good yield by allowing a phenol compound (I) to react with a stilbene compound (II) in the presence of methanesulfonic acid STR1