1032903-64-2Relevant articles and documents
Preparation method of ceritinib and key intermediate thereof
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Paragraph 0066; 0067, (2018/09/12)
The invention discloses a preparation method of ceritinib and a key intermediate thereof and belongs to the field of medicinal chemistry. The purity of a final product is high and reaches 99.7 percentand the yield is high and reaches 92.7 percent; the preparation method is simple to operate and column chromatography is not needed; furthermore, first-step reaction selectively acts on specific chlorine atoms on pyrimidine and NH in a compound 2 is protected so that side effects are few, requirements on reaction conditions are relatively low, the yield is high, the purity is high and the post-treatment is simple; industrial production is easy to realize.
Preparation method for ALK inhibitor
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, (2016/12/22)
The invention provides a preparation method for an ALK inhibitor. The preparation method comprises a step of contacting a compound as shown in a formula 4 with a compound as shown in a formula 12. The method can rapidly and efficiently prepare the target ALK inhibitor and is simple in steps, mild in reaction conditions and low in cost.
Method for preparing ALK inhibitor ceritinib
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Page/Page column 15-18, (2016/04/26)
Embodiment of present disclosure provides a method for preparing ceritinib of formula I, comprising: (1) contacting a compound of formula 12b with an amino protective group to obtain a compound of formula 3; (2) contacting the compound of formula 3 with a compound of formula 9a to obtain a compound of formula 5; and (3) subjecting the compound of formula 5 to a deprotection reaction to obtain the ceritinib of formula I. Then ceritinib may be effectively prepared.