1032903-63-1Relevant articles and documents
CHEMICAL PROCESS FOR PREPARING PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF
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, (2021/05/21)
PROBLEM TO BE SOLVED: To provide a process for preparing ceritinib and/or intermediates thereof. SOLUTION: There is provided a process for preparing (C2-1), an intermediate of ceritinib synthesis, comprising the step of reacting (A) with (B) in a solvent in the presence of at least one catalyst, wherein P is a protecting group and T and X1 independently denote Cl and the like. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
Anti-tumor compound and application thereof
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Paragraph 0068-0070, (2020/10/29)
The present invention relates to a compound having a structure of formula I, in which the substituent R is C6-C8 cycloalkyl, aryl, n R1 substituted aryl, or n R1 substituted C6-C8 cycloalkyl, n being1-4; wherein the R1 is independently selected from a halogen atom, a C1-C6 alkyl group, a C2-C4 alkenyl group, a C2-C3 alkynyl group, a fluorine-substituted C1-C4 alkyl group, a phenyl group, a substituted phenyl group, a nitro group, a pyridyl group, a pyrrolyl group, a pyrazinyl group, a piperazinyl group and a furyl group; the R2 is a C1-C3 alkyl group; R3 is a C1-C4 alkyl group; and R4 is a compound containing o-aminophenyl, m-aminophenyl, p-aminophenyl, pyrrolyl, pyridyl, piperidyl, piperazinyl, pyrazinyl, pyrimidinyl and quinolyl.
CHEMICAL PROCESS FOR PREPARING PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF
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Paragraph 0164, (2020/01/09)
PROBLEM TO BE SOLVED: To provide a method for producing intermediates for preparing ceritinib. SOLUTION: There is provided a method for preparing (C2-1), comprising reacting (A) with (B) in a solvent in the presence of at least one catalyst, wherein P is a protecting group and T and X1 can be independently C1 and the like. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT