1033074-47-3

Upstream product

• 1029083-72-4 (2S,3S)-5-(4-methoxybenzyloxy)-3-methylpentane-1,2-diol 
• 158817-21-1 (E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol 
• 242808-65-7 ((2R,3R)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)methanol 
• 558-13-4 carbon tetrabromide 

Downstream Products

• 1033074-22-4 (S)-1-methoxy-4-((3-methylpent-4-ynyloxy)methyl)benzene 
• 1315317-40-8 (3S,8S,E)-12-(tert-butyldiphenylsiloxy)-1-(4-methoxybenzyloxy)-3,8-dimethyldodec-10-en-4-yn-6-one 
• 1315317-41-9 (7S,12S,E)-3,3-diethyl-7,12,19,19-tetramethyl-18,18-diphenyl-4,17-dioxa-3,18-disilaicos-14-en-8-yn-10-one 
• 1315317-50-0 C₃₀H₄₀O₃Si 
• 1315317-42-0 (7S,8E,12S,14E)-3,3-diethyl-7,8,12,19,19-pentamethyl-18,18-diphenyl-4,17-dioxa-3,18-disilaicosa-8,14-dien-10-one 
• 1315317-43-1 (6E,9S,12E,14S)-18,18-diethyl-2,2,9,13,14-pentamethyl-11-methylene-3,3-diphenyl-4,17-dioxa-3,18-disilaicosa-6,12-diene 
• 1315317-51-1 (3S,4E,8S,10E)-12-(tert-butyldiphenylsilyloxy)-3,4,8-trimethyl-6-methylenedodeca-4,10-dien-1-ol 
• 1315317-36-2 (3S,4E,8S,10E)-12-(tert-butyldiphenylsilyloxy)-3,4,8-trimethyl-6-methylenedodeca-4,10-dienal 
• 1315317-47-5 (6R,8R,9S,10R,13S,15S,16E,20S,22E)-6,9,10-tris(tert-butyldimethylsiloxy)-13-hydroxy-2,2,3,3,8,15,16,20,27,27-decamethyl-18-methylene-26,26-diphenyl-4,25-dioxa-3,26-disilaoctacosa-16,22-dien-11-one 
• 1315317-48-6 (6R,8R,9S,10R,13R,15S,16E,20S,22E)-6,9,10-tris(tert-butyldimethylsiloxy)-13-hydroxy-2,2,3,3,8,15,16,20,27,27-decamethyl-18-methylene-26,26-diphenyl-4,25-dioxa-3,26-disilaoctacosa-16,22-dien-11-one 

Relevant academic research and scientific papers

Synthesis of the C7-26 fragment of amphidinolides G and H

A new approach to the synthesis of the C7-26 fragment of amphidinolides G and H was developed. In the sequence, the C7-18 portion of this fragment was synthesized using an acetylide coupling protocol, while an Evans alkylation and Sharpless asymmetric dihydroxylation were employed as key steps in construction of the C19-26 subfragment. Finally, both of these units were joined by utilizing an aldol coupling reaction to produce the target C7-26 fragment in good yield.

Synthesis of the ABC-ring models of goniodomin A: preference for the unnatural configuration at C11 of the BC-ring in a non-macrocyclic model system

To confirm the natural relative stereochemistry of the ABC-ring of goniodomin A (1), the corresponding three stereoisomeric compounds, (2R,5S,6S,7S,9S,11R,15S)-, (2R,5S,6S,7R,9R,11S,15R)-, and (2R,5S,6S,7R,9R,11R,15S)-isomers (2, 3, and 5, respectively),