103373-62-2 Usage
Chemical class
Benzodiazepine
Function
Competitive antagonist at the benzodiazepine binding site on the GABA receptor complex
Use
Antidote to reverse the effects of benzodiazepines, specifically in cases of overdose or to reverse the sedative effects of these drugs
Mechanism of action
Binds to the benzodiazepine receptor and displaces the benzodiazepine, effectively blocking the actions of the drug and reversing its effects
Importance
Life-saving medication in cases of benzodiazepine overdose and critical in the treatment of benzodiazepine addiction and withdrawal.
Check Digit Verification of cas no
The CAS Registry Mumber 103373-62-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,3,7 and 3 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 103373-62:
(8*1)+(7*0)+(6*3)+(5*3)+(4*7)+(3*3)+(2*6)+(1*2)=92
92 % 10 = 2
So 103373-62-2 is a valid CAS Registry Number.
103373-62-2Relevant articles and documents
Synthesis and Resolution of 3-Amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-ones
Bock, Mark G.,DiPardo, Robert M.,Evans, Ben E.,Rittle, Kenneth E.,Veber, Daniel F.,et al.
, p. 3232 - 3239 (2007/10/02)
Two efficient synthetic routes to the 3-amino-1,4-benzodiazepin-2-ones 2 and 3 were developed.The first sequence was carried out in 55-60percent overall yield and involves a novel mercuric ion assisted ammonia displacement of the (alkylthio)glycinamide 14 to produce the key intermediate α-aminoglycinamide 15.The second approach features a practical two-step amination of the parent 1,4-benzodiazepine ring system 24 to afford the title compound 3 in 49percent overall yield from 2-aminobenzophenone.The 3-amino-1,4-benzodiazepine 3 was resolved via the separation of the corresponding diastereomeric phenylalanyl amides.The desired (-)-3 enantiomer was then liberated by use of the Edman degradation.
