103562-92-1Relevant articles and documents
An efficient MnCl2-catalyzed tandem acylation-cross-coupling reaction of o-halobenzoyl chloride with diorganyl magnesium compounds
Zhang, Fengmin,Shi, Zhuangzhi,Chen, Feng,Yuan, Yu
experimental part, p. 57 - 63 (2010/10/21)
An efficient tandem cross-coupling reaction of o-chlorobenzoyl chloride with dialkyl and diaryl magnesium compounds in the presence of manganese (II) chloride was developed, which proceeds in good yield under mild conditions. Copyright
Directed Lithiation of Tertiary β-Amino Benzamides
Comins, Daniel L.,Brown, Jack D.
, p. 3566 - 3572 (2007/10/02)
The directed ortho-lithiation-alkylation of several tertiary β-amino benzamides was studied.The ortho-substituted β-amino benzamides were hydrolyzed directly with 6 N hydrochloric acid, or by a three-step, one-pot reaction involving methylation, elimination, and treatment with aqueous acid. o-Toluic acid, 2-n-butylbenzoic acid, 2-methoxy-6-methylbenzoic aicd, and 4-methoxy-2-methylbenzoic acid were prepared by using this ortho-metalation-hydrolysis methodology.Ortho-lithiation and reaction with benzaldehyde or dimethylformamide followed by hydrolysis with aqueous acid gave lactones in good yield.Methanolysis of N-(4-methoxy-2-methyl benzoyl)-N'-methylpiperizine with sulfuric acid/methanol gave methyl 4-methoxy-2-methylbenzoate in 71percent yield.The conversion of tertiary benzamides into ketones and aldehydes was examined.Treatment of certain tertiary benzamides with alkyllithium reagents gave ketones, while reaction with a modified aluminum hydride reagent gave aldehydes