103660-47-5Relevant articles and documents
Synthesis and Pharmacological Evaluation of Novel Pyrazolyl Piperidine Derivatives as Effective Antiplatelet Agents
Soni, Jigar Y.,Tamboli, Riyaj S.,Giridhar, Rajani,Yadav, Mange Ram,Thakore, Sonal
, p. 1279 - 1286 (2017/03/27)
The synthesis and antiplatelet activity of substituted pyrazolyl piperidine derivatives (3a–n) are described. These compounds were synthesized by an improved ring opening reaction of 2-arylidene quinuclidinone using hydrazine hydrate under mild conditions
SYNTHESIS, STRUCTURE, AND PROPERTIES OF PYRAZOLOQUINUCLIDINE DERIVATIVES
Turchin, K. F.,Yanina, A. D.,Filipenko, T. Ya.,Mikhlina, E. E.,Sheinker, Yu. N.,Yakhtonov, L. N.
, p. 1039 - 1048 (2007/10/02)
It was shown by means of 1H and 13C NMR spectroscopy that the reaction of 2-arylmethylene-3-oxoquinuclidines with hydrazine hydrate gives 4a-hydroxy-7-aryl-4a,5,7,7a-tetrahydropyrazoloquinuclidines, which are stable in the crystalline state but undergo dehydration to the corresponding 7-aryl-6H-7,7a-dihydropyrazoloquinuclidines in solutions.The latter undergo cleavage to the 3-(4-piperidyl)-5-arylpyrazoles when they are heated in an alkaline medium.