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103660-47-5

4-[5-(4-METHOXYPHENYL)-1H-PYRAZOL-3-YL]PIPERIDINE, also known as MP-10, is a chemical compound with a molecular formula C21H25N3O. It belongs to the class of piperidines and pyrazoles, characterized by a pyrazole ring substituted with a 4-methoxyphenyl group and a piperidine ring. MP-10 is often used in the field of medicinal chemistry as a potential inhibitor of catechol-O-methyltransferase (COMT) enzymes, making it a promising candidate for the development of pharmaceuticals targeting neurological disorders such as Parkinson's disease.

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  • 103660-47-5 Structure

  • Basic information

    1. Product Name: 4-[5-(4-METHOXYPHENYL)-1H-PYRAZOL-3-YL]PIPERIDINE
    2. Synonyms: 4-[5-(4-METHOXYPHENYL)-1H-PYRAZOL-3-YL]PIPERIDINE;METHYL 4-[3-(4-PIPERIDINYL)-1H-PYRAZOL-5-YL]PHENYL ETHER
    3. CAS NO:103660-47-5
    4. Molecular Formula: C15H19N3O
    5. Molecular Weight: 257.33
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 103660-47-5.mol

  • Chemical Properties

    1. Melting Point: 181-183°
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-[5-(4-METHOXYPHENYL)-1H-PYRAZOL-3-YL]PIPERIDINE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-[5-(4-METHOXYPHENYL)-1H-PYRAZOL-3-YL]PIPERIDINE(103660-47-5)
    11. EPA Substance Registry System: 4-[5-(4-METHOXYPHENYL)-1H-PYRAZOL-3-YL]PIPERIDINE(103660-47-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 103660-47-5(Hazardous Substances Data)

103660-47-5 Usage

Uses

Used in Pharmaceutical Industry:
4-[5-(4-METHOXYPHENYL)-1H-PYRAZOL-3-YL]PIPERIDINE is used as a potential inhibitor of catechol-O-methyltransferase (COMT) enzymes for its ability to target neurological disorders such as Parkinson's disease. Its unique structure allows it to interact with COMT enzymes, potentially leading to improved treatment options for patients suffering from these conditions.
Further research and studies are ongoing to determine the full extent of MP-10's potential therapeutic properties and applications, with the aim of developing more effective treatments for neurological disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 103660-47-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,6,6 and 0 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 103660-47:
(8*1)+(7*0)+(6*3)+(5*6)+(4*6)+(3*0)+(2*4)+(1*7)=95
95 % 10 = 5
So 103660-47-5 is a valid CAS Registry Number.

103660-47-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[3-(4-methoxyphenyl)-1H-pyrazol-5-yl]piperidine

1.2 Other means of identification

Product number -
Other names methyl 4-[3-(4-piperidinyl)-1H-pyrazol-5-yl]phenyl ether

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:103660-47-5 SDS

103660-47-5Downstream Products

103660-47-5Relevant articles and documents

Synthesis and Pharmacological Evaluation of Novel Pyrazolyl Piperidine Derivatives as Effective Antiplatelet Agents

Soni, Jigar Y.,Tamboli, Riyaj S.,Giridhar, Rajani,Yadav, Mange Ram,Thakore, Sonal

, p. 1279 - 1286 (2017/03/27)

The synthesis and antiplatelet activity of substituted pyrazolyl piperidine derivatives (3a–n) are described. These compounds were synthesized by an improved ring opening reaction of 2-arylidene quinuclidinone using hydrazine hydrate under mild conditions

Synthesis and antibacterial activity of a novel series of potent DNA gyrase inhibitors. Pyrazole derivatives

Tanitame, Akihiko,Oyamada, Yoshihiro,Ofuji, Keiko,Fujimoto, Mika,Iwai, Noritaka,Hiyama, Yoichi,Suzuki, Kenji,Ito, Hideaki,Terauchi, Hideo,Kawasaki, Motoji,Nagai, Kazuo,Wachi, Masaaki,Yamagishi, Jun-Ichi

, p. 3693 - 3696 (2007/10/03)

We have previously found that a pyrazole derivative 1 possesses antibacterial activity and inhibitory activity against DNA gyrase and topoisomerase IV. Here, we synthesized new pyrazole derivatives and found that 5-[(E)-2-(5-chloroindol-3-yl)vinyl]pyrazol

SYNTHESIS, STRUCTURE, AND PROPERTIES OF PYRAZOLOQUINUCLIDINE DERIVATIVES

Turchin, K. F.,Yanina, A. D.,Filipenko, T. Ya.,Mikhlina, E. E.,Sheinker, Yu. N.,Yakhtonov, L. N.

, p. 1039 - 1048 (2007/10/02)

It was shown by means of 1H and 13C NMR spectroscopy that the reaction of 2-arylmethylene-3-oxoquinuclidines with hydrazine hydrate gives 4a-hydroxy-7-aryl-4a,5,7,7a-tetrahydropyrazoloquinuclidines, which are stable in the crystalline state but undergo dehydration to the corresponding 7-aryl-6H-7,7a-dihydropyrazoloquinuclidines in solutions.The latter undergo cleavage to the 3-(4-piperidyl)-5-arylpyrazoles when they are heated in an alkaline medium.

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