10369-82-1

Basic information

• Product Name: 2-(diethylamino)ethyl acetate
• Synonyms: 2-(diethylamino)ethyl acetate;acetylcaine;Acetic acid 2-(diethylamino)ethyl ester
• CAS NO: 10369-82-1
• Molecular Formula: C₈H₁₇NO₂
• Molecular Weight: 159.22608
• EINECS: 233-811-5
• Mol File: 10369-82-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 199.4°Cat760mmHg
• Flash Point: 68.6°C
• Appearance: /
• Density: 0.929g/cm³
• Vapor Pressure: 0.343mmHg at 25°C
• Refractive Index: 1.433
• CAS DataBase Reference: 2-(diethylamino)ethyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(diethylamino)ethyl acetate(10369-82-1)
• EPA Substance Registry System: 2-(diethylamino)ethyl acetate(10369-82-1)

Safety Data

• Hazardous Substances Data: 10369-82-1(Hazardous Substances Data)

Usage

General Description

2-(diethylamino)ethyl acetate is a chemical compound with the molecular formula C8H17NO2. It is a colorless liquid with a mild odor, and it is commonly used as a solvent in various applications such as in paints, varnishes, and coatings. It is also used as a reagent in organic synthesis and as a tertiary amine precursor in the pharmaceutical industry. The chemical is considered to have low toxicity and is generally regarded as safe for use in the appropriate industrial and laboratory settings. However, proper handling and storage procedures should be followed to prevent any potential hazards associated with its use.

InChI:InChI=1/C8H17NO2/c1-4-9(5-2)6-7-11-8(3)10/h4-7H2,1-3H3

Upstream product

• 108-24-7 acetic anhydride 
• 100-37-8 2-(Diethylamino)ethanol 
• 75-36-5 acetyl chloride 
• 109-89-7 diethylamine 
• 74-85-1 ethene 
• 64-19-7 acetic acid 
• 927-68-4 bromoethyl acetate 
• 2597-54-8 ethyl acetylcarbamate 

Downstream Products

• 13324-11-3 methyl 2-chloro-4-nitrobenzoate 
• 16017-69-9 ethyl-2-chloro-4-amino-benzoate 
• 53566-04-4 N,N-diethyl-N-methylaminoethyl acetate iodide 

Relevant articles and documents

Simple and efficient method for acetylation of alcohols, phenols, amines, and thiols using anhydrous NiCl2 under solvent-free conditions

Solvent-free acetylation of alcohols, phenols, amines, and thiols with acetic anhydride (Ac2O) in the presence of 0.1mol% (13mg) anhydrous NiCl2, an inexpensive and easily available catalyst, is described. Excellent yields, short reaction time, and mild reaction conditions are important features of this method.

Dual-Channel Enzymatic Inhibition Measurement (DEIM) Coupling Isotope Substrate via Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry

A novel dual-channel enzymatic inhibition measurement (DEIM) method was developed to improve the repeatability with light/heavy isotope substrates, producing reliable relative standard deviations ( 3%) by employing acetylcholinesterase (AChE) as the model enzyme. The matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) was adapted for enzyme-inhibited method due to its good salt-tolerance and high throughput; meanwhile, dual-channel enzymatic reactions were performed to improve the repeatability of each well. The acetylcholinesterase inhibition measurement was conducted by mixing the quenched enzyme reaction solution of blank group (with heavy isotope as substrate) and experimental group (with light isotope as substrate), of which the inhibition rate might be affected by isotope effects. Hence, inverse study and Km measurement were implemented to validate the method. The inverse study shows similar inhibition rate (68.9 and 70.3%) and the Km of isotope substrates are analogous (0.139 and 0.135?mM), which demonstrated that the novel method is feasible to AChE inhibition measurement. Finally, the method was applied to herb extracts, half of which exhibit inhibition to AChE. The precise dual-channel enzymatic inhibition measurement (DEIM) method could be regarded as a promising approach to potential enzyme inhibitor screening. [Figure not available: see fulltext.].

Stereospecific Palladium-Promoted Oxyamination of Alkenes

A method for direct oxyamination of olefins to vicinal amino alcohol derivatives is described. The reaction proceeds via an aminopalladation-oxidation sequence.Terminal olefins give good yields (60-80percent) whereas internal olefins give lower yields (20-60percent).The oxyamination reaction is stereospecific as shown by reaction of (Z)- and (E)-2-butene and (E)-1-deuterio-1-decene and proceeds by overall cis stereochemistry.The stereochemical outcome is a result of a trans aminopalladation followed by an oxidative cleavage of the palladium carbon bond with inversion of configuration at carbon.Oxidation of the organopalladium ? complex to give an oxidized palladium intermediate, which could be a Pd(IV) intermediate, followed by SN2-type nucleophilic displacement of palladium is the most likely mechanism for the oxidative cleavage reaction.