10375-42-5

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 133145-92-3 1-phenylpropan-1-one O-acetyl oxime 
• 93-55-0 1-phenyl-propan-1-one 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 637-44-5 phenylpropyolic acid 
• 90-02-8 salicylaldehyde 
• 75-36-5 acetyl chloride 
• 2157-50-8 propiophenone oxime 
• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 16169-88-3 1-phenylprop-2-ynyl acetate 

Relevant academic research and scientific papers

Phosphine-mediated MBH-Type/Acyl transfer/wittig sequence for construction of functionalized furo[3,2-c]coumarins

A new method for the construction of functionalized furo[3,2-c]coumarins via MBH-type/acyl-transfer/Wittig reaction is reported. The current approach would open a new route for the simultaneous formation of two rings in a one-pot reaction which is accompanied by incorporation of a keto functionality on the furan ring by activating the terminal alkynoates with phosphine. Furthermore, this protocol could also be applicable to the internal alkynoates/propiolamides to generate the 2,3-disubstituted furo[3,2-c]coumarins/furo[3,2-c]quinolinones by excluding the acyl-transfer reaction.

A convenient synthesis of furo[3,2-c]coumarins by a tandem alkylation/intramolecular aldolisation reaction

A simple and efficient synthesis of furo[3,2-c]coumarin derivatives from 4-hydroxycoumarin and α-haloketones via a tandem O-alkylation/cyclisation protocol is described.

Copper-Catalyzed Synthesis of Furo[3,2- c ]coumarins and Dihydrofuro[3,2- c ]coumarins through a Propargylation/Alkyne Oxacyclization/Isomerization Cascade under Microwave Irradiation

A novel copper-catalyzed microwave-promoted propargylation/alkyne oxacyclization/isomerization cascade for the synthesis of 2-methylfuro[3,2-c]coumarins has been developed. This reaction provides furo[3,2-c]coumarins in moderate to good yields (≤82%) from

Regioselective Bismuth-Catalyzed Synthesis of Pyranocoumarins and Furocoumarins from 4-Hydroxycoumarins and Propargyl Alcohols

An efficient method for the bismuth-catalyzed regioselective synthesis of pyranocoumarins and furocoumarins has been developed from the reaction of 4-hydroxycoumarins with propargyl alcohols. The reaction proceeds through sequential propargylation and int

Iodine-mediated formal [3 + 2] annulation for synthesis of furocoumarin from oxime esters

A novel synthesis of furocoumarins was developed by a reaction between oxime esters and 4-hydroxycoumarins. The reaction was proposed to undergo radical mechanism mediated by iodine, a cheap and common laboratory reagent. Mechanistic studies showed the ke

Metal-Free Synthesis of Furocoumarins: An Approach via Iodine-Promoted One-Pot Cyclization between 4-Hydroxycoumarins and Acetophenones

A transition metal-free approach was developed to achieve substituted furocoumarins via an iodine-promoted one-pot cyclization between 4-hydroxycoumarins and acetophenones. High yields of furocoumarins were achieved in the presence of NH4OAc as

A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes

A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes was developed. CuBr2 exhibited higher activity than other copper salts, affording the desired furocoumarins in high yields. The transformation proceeded readily in the absence of stoichiometric external oxidants. The significance of this synthetic strategy would be (1) the easily available starting materials; (2) low cost catalyst CuBr2; and (3) being without stoichiometric external oxidants. This protocol is complementary to previous approaches in the synthesis of substituted furocoumarins.

Regioselective Access to Structurally Diverse Coumarin Analogues through Iron-Catalysed Annulation Reactions

A highly efficient iron-catalysed propargylation/alkyne oxacyclization/isomerization strategy is described. Biologically active furo[3,2-c]coumarins and pyrano[3,2-c]coumarins are expeditiously assembled in moderate to good yields and with a broad substrate scope. The regioselective access to different coumarins is mainly dependent on the terminal group of the secondary propargylic alcohol.

METHOD OF PREPARING FURO[3.2-c]COUMARIN DERIVATIVES USING Cu CATALYST

The present invention relates to a method for preparing novel furo[3.2-c]coumarin derivatives using a copper catalyst, which can simply and efficiently prepare furo[3.2-c]coumarin derivatives by using a copper catalyst. The preparing method uses a copper catalyst to obtain a target material in high yield, and the furo[3.2-c]coumarin derivatives prepared at the same time can be used in synthesis of intermediate product of a medicine and a natural product. Specifically, the method is characterized by preparing furo[3.2-c]coumarin derivatives by reacting a 4-hydroxy coumarin compound and a propargyl alcohol compound under existence of a copper catalyst and a solvent.COPYRIGHT KIPO 2015

DABCO-promoted one-pot facile synthesis of angularly fused furoquinolinones and furocoumarins

A DABCO-promoted intermolecular cyclization between enols and nitrostyrenes has been developed for the regioselective synthesis of angularly fused furan derivatives in high yields. This protocol is applicable to various enol derivatives, including 4-hydroxyquinolinones, 4-hydroxycoumarin, and 4-hydroxypyranone. A method for the regioselective synthesis of angularly fused polysubstituted furan derivatives by a DABCO-promoted intermolecular cyclization between enols and nitrostyrenes was developed. The reaction has great advantages in terms of its operational simplicity, cost-effectiveness, and environmental impact.