10376-59-7

Basic information

• Product Name: 3-(2-hydroxyethyl)-2-methylquinazolin-4(3H)-one
• CAS NO: 10376-59-7
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.2252
• Mol File: 10376-59-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 388.4°C at 760 mmHg
• Flash Point: 188.7°C
• Density: 1.26g/cm³
• Vapor Pressure: 9.98E-07mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 3-(2-hydroxyethyl)-2-methylquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-hydroxyethyl)-2-methylquinazolin-4(3H)-one(10376-59-7)
• EPA Substance Registry System: 3-(2-hydroxyethyl)-2-methylquinazolin-4(3H)-one(10376-59-7)

Safety Data

• Hazardous Substances Data: 10376-59-7(Hazardous Substances Data)

Upstream product

• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 141-43-5 ethanolamine 
• 118-92-3 anthranilic acid 
• 1885-29-6 anthranilic acid nitrile 
• 3416-93-1 2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline 
• 78-39-7 Triethyl orthoacetate 
• 879094-46-9 2-(2-methyl-4-oxo-3,4-dihydro-3-quinazolinyl)ethyl acetate 
• 107-07-3 2-chloro-ethanol 
• 89-52-1 o-acetylamino-benzoic acid 

Downstream Products

• 68501-37-1 3-(2-hydroxyethyl)-2-(2-phenylethenyl)quinazolin-4(3H)-one 
• 111970-09-3 3-(2-benzoyloxyethyl)-2-(2-phenylethenyl)quinazolin-4(3H)-one 
• 111970-11-7 3-(2-benzoyloxyethyl)-2-(1,2-epoxy-2-phenylethyl)quinazolin-4(3H)-one 
• 111970-13-9 11H-5-acetoxy-1,2,4,5-tetrahydro-4-phenyl<1,4>oxazepino<5,4-b>quinazolin-11-one 
• 111970-10-6 2-(1,2-epoxy-2-phenylethyl)-3-(2-hydroxyethyl)quinazolin-4(3H)-one 
• 111970-12-8 11H-5-hydroxy-1,2,4,5-tetrahydro-4-phenyl<1,4>oxazepino<5,4-b>quinazolin-11-one 
• 132808-52-7 o-Tolylamino-acetic acid 2-[4-oxo-2-((E)-styryl)-4H-quinazolin-3-yl]-ethyl ester 
• 132808-49-2 2-phenyl-4(3H)-oxoquinazolin-3-ylethyl chloroacetate 
• 132808-61-8 3-{2-[3-(4-Chloro-phenylamino)-2-hydroxy-propoxy]-ethyl}-2-methyl-3H-quinazolin-4-one 

Relevant articles and documents

Synthesis of quinazoin-4-ones through an acid ion exchange resin mediated cascade reaction

An interesting cascade reaction of N-(2-(4,5-dihydrooxazol-2-yl)phenyl)benzamide in the presence of an acid ion exchange resin is described. In this reaction, a range of substrates bearing various substituent groups are well compatible. This work provides a green and atom-economical alternative approach for the synthesis of quinazolin-4-ones in good yields.

Investigating biological activity spectrum for novel styrylquinazoline analogues

In this study, series of ring-substituted 2-styrylquinazolin-4(3H)-one and 4-chloro-2-styrylquinazoline derivatives were prepared. The syntheses of the discussed compounds are presented. The compounds were analyzed by RP-HPLC to determine lipophilicity. They were tested for their inhibitory activity on photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than that of the standard isoniazid. It was found that the electronic properties of the R substituent, and not the total lipophilicity of the compound, were decisive for the photosynthesis-inhibiting activity of tested compounds.

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