10388-32-6

Upstream product

• 1774-66-9 3-(4-bromophenyl)-1-phenylprop-2-en-1-one 
• 22966-09-2 (2E)-3-(4-bromophenyl)-1-phenylprop-2-en-1-one 
• 1122-91-4 4-bromo-benzaldehyde 
• 98-86-2 acetophenone 
• 75-15-0 carbon disulfide 
• 7726-95-6 bromine 
• 2403-27-2 1-(4-bromophenyl)-3-phenyl-2-propen-1-one 

Downstream Products

• 7464-89-3 1,3,6,8-tetramethyl-1H,3H,6H,8H-pyrimido[4,5-g]pteridine-2,4,7,9-tetraone 
• 147622-96-6 5-Amino-6-[(E)-1-(4-bromo-phenyl)-3-oxo-3-phenyl-propenylamino]-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 117836-45-0 1-(4-Bromo-phenyl)-2-phenyl-1,1a-dihydro-3,7b-diaza-cyclopropa[a]naphthalene 
• 74990-02-6 (4R,5R)-4-Bromo-5-(4-bromo-phenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole 
• 74989-93-8 (4R,5R)-4-Bromo-5-(4-bromo-phenyl)-1-(2,4-dinitro-phenyl)-3-phenyl-4,5-dihydro-1H-pyrazole 
• 127019-17-4 6-(4-Bromo-phenyl)-2,2-dimethyl-4-phenyl-1,3-diaza-bicyclo[3.1.0]hex-3-ene 
• 1774-66-9 3-(4-bromophenyl)-1-phenylprop-2-en-1-one 
• 87275-47-6 5-Bromo-6-(4-bromo-phenyl)-4-phenyl-5,6-dihydro-1H-pyrimidin-2-one 
• 140861-26-3 (2R,5S,6R)-6-(4-Bromo-phenyl)-2-(2-nitro-phenyl)-4-phenyl-1,3-diaza-bicyclo[3.1.0]hex-3-ene 
• 140861-26-3 (2S,5S,6R)-6-(4-Bromo-phenyl)-2-(2-nitro-phenyl)-4-phenyl-1,3-diaza-bicyclo[3.1.0]hex-3-ene 
• 22966-09-2 (2E)-3-(4-bromophenyl)-1-phenylprop-2-en-1-one 
• 127019-12-9 4-phenyl-6-(4-bromophenyl)-1,3-diazabicyclo<3.1.0>hex-3-ene 
• 25856-01-3 1-(4-bromophenyl)-3-phenylpropane-1,3-dione 
• 1083-30-3 dihydrochalcone 

Relevant academic research and scientific papers

New nicotinic acid-based 3,5-diphenylpyrazoles: design, synthesis and antihyperlipidemic activity with potential NPC1L1 inhibitory activity

Nicotinic acid hydrazide was incorporated into new 4,5-dihydro-5-hydroxy-3,5-diphenylpyrazol-1-yl derivatives. Compounds 6a–h were synthesized, and their antihyperlipidemic activity was evaluated in high cholesterol diet-fed rat model. Compounds 6e, 6f were found to decrease the levels of serum total cholesterol by 14–19% compared to control group. Total triglycerides were also reduced by 24–28% and LDL cholesterol by 16%. As expected from parent niacin, compounds 6e and 6f caused an elevation of HDL cholesterol by 33–41%. Docking study supported the ability of designed compounds to block NPC1L1 active site in a manner similar to that observed with ezetimibe.

One-pot three-component approach to the synthesis of polyfunctional pyrazoles

A simple, multicomponent, and straightforward reaction of vinyl azide, aldehyde, and tosylhydrazine affords the construction of 3,4,5-trisubstituted 1H-pyrazoles regioselectively in the presence of base with moderate to excellent yields. A range of functionality could be tolerated in this methodology, and a possible mechanism is proposed.

Synthesis of vinyl-substituted β-diketones for polymerizable metal complexes

Polymerizable β-diketones for application to metal ion coordination have been prepared and characterized. Bromine-substituted β-diketones were synthesized under Claisen-Schmidt-type condensation conditions. Vinyl groups were substituted for the halide by

Solvolytic stereoselective debromination of vic-dibromides with HMPA

A simple and efficient procedure for the debromination of vic-dibromides has been reported with hexamethylphosphoric triamide at 155-160°C under a nitrogen atmosphere without the aid of any reagent.