103913-29-7

Basic information

• Product Name: Acetamide, N-[4-(4-morpholinyl)phenyl]-
• CAS NO: 103913-29-7
• Molecular Formula: C12H16N2O2
• Molecular Weight: 220.271
• Mol File: 103913-29-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[4-(4-morpholinyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[4-(4-morpholinyl)phenyl]-(103913-29-7)
• EPA Substance Registry System: Acetamide, N-[4-(4-morpholinyl)phenyl]-(103913-29-7)

Safety Data

• Hazardous Substances Data: 103913-29-7(Hazardous Substances Data)

Upstream product

• 5414-19-7 1,1'-oxybis(2-bromo-ethane) 
• 122-80-5 N-acetyl-p-phenylenediamine 
• 110-91-8 morpholine 
• 10352-44-0 4'-(methylthio)acetanilide 
• 34604-52-9 diethylene glycol dimesylate 
• 10389-51-2 1-morpholino-4-nitrobenzene 
• 5382-54-7 4-(4-nitroso-phenyl)-morpholine 
• 2524-67-6 4-morpholino-4-yl-phenylamine 
• 108-24-7 acetic anhydride 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 103-88-8 4-bromoacetanilide 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 

Downstream Products

• 5367-49-7 N-(4-morpholinyl-2-nitrophenyl)acetamide 
• 5367-48-6 N-(4-morpholin-4-yl-3-nitro-phenyl)-acetamide 
• 182804-91-7 ethyl-(4-morpholin-4-yl-phenyl)-amine 
• 182804-90-6 Ethyl-(4-morpholin-4-yl-phenyl)-carbamic acid ethyl ester 

Relevant articles and documents

Palladium-catalyzed amination of aryl sulfides with aliphatic amines

Conditions for the palladium-NHC-catalyzed amination of aryl sulfides with aliphatic as well as aromatic amines were established. The KHMDS-mediated amination of heteroaryl sulfides could proceed without palladium. Based on the distinct difference in reactivity of C-Br and C-S bonds, a sequential amination of bromothioanisole can take place to install two different alkylamino groups onto the aromatic ring in one pot. A palladium-NHC precatalyst shows high efficiency for C-S bond cleavage for the amination of aryl sulfides with aliphatic amines or aromatic amines.

Practical Catalytic Cleavage of C(sp3)?C(sp3) Bonds in Amines

The selective cleavage of thermodynamically stable C(sp3)?C(sp3) single bonds is rare compared to their ubiquitous formation. Herein, we describe a general methodology for such transformations using homogeneous copper-based catalysts in the presence of air. The utility of this novel methodology is demonstrated for Cα?Cβ bond scission in >70 amines with excellent functional group tolerance. This transformation establishes tertiary amines as a general synthon for amides and provides valuable possibilities for their scalable functionalization in, for example, natural products and bioactive molecules.

Rapid and convenient synthesis of N-arylmorpholines under microwave irradiation

A series of N-arylmorpholines 1a-1n was obtained by cyclocondensation of arylamines and diethylene glycol dimesylate under microwave irradiation in an aqueous potassium carbonate medium. The reaction is rapid and convenient, and a variety of functional groups are tolerated in the process.