10399-09-4

Upstream product

• 67-56-1 methanol 
• 102862-46-4 3-p-Tolyl-oxirane-2,2-dicarbonitrile 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 23786-13-2 methyl p-tolylacetate 
• 124-41-4 sodium methylate 
• 624-31-7 4-tolyl iodide 
• 107940-08-9 (Z)-1,2-dimethoxy-1-(trimethylsilyloxy)ethylene 
• 122-00-9 para-methylacetophenone 
• 149-73-5 trimethyl orthoformate 

Relevant academic research and scientific papers

Palladium-catalysed Arylation of α-Methoxyketene Methyl Silyl Acetals

Methyl α-methoxyarylacetates 3 have been synthesized by the palladium-catalysed reaction of iodobenzenes 1 with α-methoxyketene methyl silyl acetals 2.The diastereoselective and enantioselective synthesis of the arylacetates has also been examined.

A facile one-pot synthesis of α-hydroxy acids and their derivatives

2-Substituted oxirane-1,1-dicarbonitriles react with water, alcohols or phenol to give 2-substituted 2-hydroxyacetic acids, alkyl-2-alkoxyacetates and phenyl 2-phenoxyacetates, respectively. Reaction of 2-substituted oxirane-1,1-dicarbonitrile with thiophenol and a nucleophile, typically water ethanol or urea, gave 2-(phenylthio)acetic acids, ethyl 2-(phenylthio)acetates and N-aminocarbonyl-2-(phenylthio)acetamides.

Hypervalent Iodine Oxidation of Aryl Methyl Ketones: A Convenient Route to Methyl α-Methoxyarylacetates

Hypervalent iodine oxidation of aryl methyl ketones using two equivalents of iodosobenzene diacetate leads to 1,2-aryl migration followed by solvohyperiodination to yield the corresponding methyl α-methoxyarylacetates.

HYPERVALENT IODINE IN ORGANIC SYNTHESIS. A NEW ROUTE TO α-FUNCTIONALIZED CARBOXYLATE ESTERS.

Aryl and alkylcarboxylate esters are converted into the corresponding α-hydroxy acids or α-alkoxyesters upon treatment with C6H5I(OAc)2 and base in the appropriate solvent.