Synthesis of α-(alkoxysilyl)acetic esters. A route to 1,2 diols

Article abstract of DOI:10.1016/0040-4020(95)00763-X

An easy route to α-(alkoxysilyl)acetic esters and their utilization is described. It involves a two-step sequence carried out in one pot Rhodium catalyzed Si-H insertion of a carbenoid, generated by decomposition of N₂CHCO₂Et, followed by a nucleophilic attack onto the Si-Cl bond by an alcohol. Alkylation of the title esters, reduction of the ester function and finally oxidation of the C-Si bond provide a facile entry to 1,2 diols.