33864-03-8Relevant articles and documents
Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells
Robles, Andrew J.,McCowen, Shelby,Cai, Shengxin,Glassman, Michaels,Ruiz, Francisco,Cichewicz, Robert H.,McHardy, Stanton F.,Mooberry, Susan L.
, p. 9275 - 9289 (2017/11/30)
Targeted therapies for ER+/PR+ and HER2-amplified breast cancers have improved patient survival, but there are no therapies for triple negative breast cancers (TNBC) that lack expression of estrogen and progesterone receptors (ER/PR), or amplification or
Ligandless microwave-assisted Pd/Cu-catalyzed direct arylation of oxazoles
Besselievre, Francois,Mahuteau-Betzer, Florence,Grierson, David S.,Piguel, Sandrine
, p. 3278 - 3280 (2008/09/19)
(Chemical Equation Presented) An efficient microwave-assisted palladium/copper co-mediated direct arylation of oxazoles with aryl bromides under ligandless conditions has been developed. The method is functional group tolerant and provides rapid access to medicinally relevant compounds in good yields. Coupled to the van Leusen oxazole ring synthesis, this methodology is illustrated by an expedient two-step synthesis of the four 2,5-diaryloxazole alkaloids texamine, texaline, balsoxin, and O-Me-halfordinol from commercially available starting materials.
Combinatorial discovery of novel fluorescent dyes based on Dapoxyl
Zhu, Qing,Yoon, Hai-Shin,Parikh, Puja B.,Chang, Young-Tae,Yao, Shao Q.
, p. 5083 - 5086 (2007/10/03)
We have developed a combinatorial method for the fast and effective synthesis of a library based on a known fluorescent dye, Dapoxyl using parallel solution-phase chemistry. By screening the 140 new compounds using fluorescence-based assays, we identified three new fluorescent dyes with novel properties.