33864-03-8

Upstream product

• 10400-19-8 3-pyridinecarbonyl chloride 
• 55275-61-1 2-amino-1-(4-methoxyphenyl)ethanol 
• 6595-28-4 2-azido-1-(4-methoxyphenyl)ethan-1-one 
• 4195-29-3 3-[5-(4-benzyloxy-phenyl)-oxazol-2-yl]-pyridine 
• 626-55-1 3-Bromopyridine 
• 1011-51-4 5-(4-methoxyphenyl)-1,3-oxazole 
• 626-60-8 3-Chloropyridine 
• 123-11-5 4-methoxy-benzaldehyde 
• 4195-27-1 N-[2-(4-benzyloxy-phenyl)-2-oxo-ethyl]-nicotinamide 
• 40513-43-7 2-amino-1-(4-methoxy-phenyl)-ethanone 
• 59-67-6 nicotinic acid 
• 4122-63-8 N-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-nicotinamide 
• 186581-53-3 diazomethane 
• 4210-82-6 halfordinol 

Downstream Products

• 34433-52-8 5-[5-(4-methoxy-phenyl)-oxazol-2-yl]-1-methyl-pyridinium; iodide 
• 17190-80-6 5-(4-[(3-methylbut-2-en-1-yl)oxy]phenyl)-2-(pyridin-3-yl)oxazole 
• 4210-82-6 halfordinol 
• 89764-17-0 (E)-5-(4-[(3,7-dimethylocta-2,6-dien-1-yl)oxy]phenyl)-2-(pyridin-3-yl)oxazole 

Relevant academic research and scientific papers

Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells

Targeted therapies for ER+/PR+ and HER2-amplified breast cancers have improved patient survival, but there are no therapies for triple negative breast cancers (TNBC) that lack expression of estrogen and progesterone receptors (ER/PR), or amplification or

Direct C-H bond arylation of (benzo)oxazoles with aryl chlorides catalyzed by N-heterocyclic carbene-palladium(II)-1-methylimidazole complex

The direct C-H bond arylation of (benzo)oxazoles with aryl chlorides was achieved catalyzed by a well-defined NHC-Pd(II)-Im complex. Under the optimal conditions, various aryl chlorides were successfully applied as the arylating reagents to achieve the 2-aryl (benzo)oxazoles in acceptable to high yields, providing a convenient and alternative method for the direct C-H bond arylation of (benzo)oxazoles and enriching the chemistry of the NHC-Pd(II) complex in organic synthesis.

Ligandless microwave-assisted Pd/Cu-catalyzed direct arylation of oxazoles

(Chemical Equation Presented) An efficient microwave-assisted palladium/copper co-mediated direct arylation of oxazoles with aryl bromides under ligandless conditions has been developed. The method is functional group tolerant and provides rapid access to medicinally relevant compounds in good yields. Coupled to the van Leusen oxazole ring synthesis, this methodology is illustrated by an expedient two-step synthesis of the four 2,5-diaryloxazole alkaloids texamine, texaline, balsoxin, and O-Me-halfordinol from commercially available starting materials.

2,5-SUBSTITUTED OXAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER

Certain oxazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.

Combinatorial discovery of novel fluorescent dyes based on Dapoxyl

We have developed a combinatorial method for the fast and effective synthesis of a library based on a known fluorescent dye, Dapoxyl using parallel solution-phase chemistry. By screening the 140 new compounds using fluorescence-based assays, we identified three new fluorescent dyes with novel properties.

Iminophosphorane-Mediated Synthesis Of Oxazole Alkaloids: One-Step Preparation Of O-Methylhalfordinol And Annuloline

The three-component reaction between triphenylphosphine, 4-methoxyphenacyl azide and nicotinoyl chloride or 3,4-dimethoxycinnamoyl chloride leads directly in good yields to O-methylhalfordinol or annuloline respectively.