10424-29-0

Usage

Uses

Used in Pharmaceutical Industry:
Phenylsuccinic acid is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs and medications.
Used in Fragrance and Flavoring Industry:
Phenylsuccinic acid serves as an important intermediate in the production of fragrances and flavoring compounds. Its ability to react with other molecules allows for the creation of a wide range of scents and tastes.
Used in Polymer and Resin Industry:
As a building block, phenylsuccinic acid is utilized in the preparation of polymers and resins. Its structural properties contribute to the development of materials with specific characteristics, such as strength, flexibility, and durability.
Used in Organic Chemistry and Materials Science Research:
Phenylsuccinic acid's versatile reactivity and structural properties make it a promising candidate for research in organic chemistry and materials science. It can be used to explore new reactions, synthesize novel compounds, and develop advanced materials with unique properties.
It is crucial to handle and store phenylsuccinic acid in a safe and controlled manner to minimize health and environmental hazards. Proper management of PHENYLSUCCINIC ACID ensures its safe use in various applications across different industries.

InChI:InChI=1/C10H10O4/c11-9(12)6-8(10(13)14)7-4-2-1-3-5-7/h1-5,8H,6H2,(H,11,12)(H,13,14)/p-2/t8-/m0/s1

Upstream product

• 13706-68-8 (+-)-phenylsuccinonitrile 
• 14387-18-9 3-cyano-3-phenyl propionic acid 
• 14025-83-3 3-cyano-3-phenylpropanoic acid ethyl ester 
• 68060-17-3 3-phenyl-1,5-heptadiene 
• 51367-64-7 3-chloro-5-phenylcyclohex-2-en-1-one 
• 4965-21-3 2-phenyl-ethane-1,1,2-tricarbonitrile 
• 5473-13-2 ethyl 2,3-dicyano-3-phenylpropanoate 
• 59106-33-1 ethyl 2-bromo-3-phenylacrylate 
• 151-50-8 potassium cyanide 
• 1071-36-9 sodium cyanoacetate 
• 100-52-7 benzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 64-17-5 ethanol 
• 4192-77-2 ethyl cinnamate 

Downstream Products

• 15463-92-0 dimethyl 2-phenylsuccinate 
• 15463-92-0 (S)-(+)-dimethyl 2-phenylsuccinate 
• 34861-81-9 diethyl phenylsuccinate 
• 634-22-0 phenyl-succinic acid bis-(1H,1H,7H-dodecafluoro-heptyl ester) 
• 21021-53-4 4-Nitrophenylsuccinic acid 
• 4036-30-0 (S)-2-phenylsuccinic acid 
• 46292-93-7 R-(+)-phenylsuccinic acid 
• 1489-63-0 2-cyclohexylsuccinic acid 
• 73923-85-0 1-(2-hydroxy-ethyl)-3-phenyl-pyrrolidine-2,5-dione 
• 58456-43-2 1-isopropyl-3-phenyl-pyrrolidine-2,5-dione 
• 150508-17-1 1-butyl-3-phenyl-pyrrolidine-2,5-dione 
• 98132-80-0 1-(2-diethylamino-ethyl)-3-phenyl-pyrrolidine-2,5-dione 
• 54433-51-1 1-allyl-3-phenyl-pyrrolidine-2,5-dione 
• 86-34-0 phensuximide 

Related news

Efficient enantioseparation of PHENYLSUCCINIC ACID (cas 10424-29-0) enantiomers by aqueous two-phase system-based biphasic recognition chiral extraction: Phase behaviors and distribution experiments08/07/2019

A novel method of aqueous two-phase system (ATPS)-based biphasic recognition chiral extraction has been developed to separate phenylsuccinic acid (PSA) enantiomers. The phase behaviors of ethanol/ammonium sulfate ATPS including phase diagrams, phase volume ratios and phase compositions were stud...detailed

Enantioselective extraction of PHENYLSUCCINIC ACID (cas 10424-29-0) in aqueous two-phase systems based on acetone and β-cyclodextrin derivative: Modeling and optimization through response surface methodology08/05/2019

A novel aqueous two-phase system (ATPS) composed of β-cyclodextrin (β-CD) derivative and acetone was developed for enantioselective extraction of racemic phenylsuccinic acid (PSA). Binodal curves, tie-lines, and critical points for the investigated ATPS were determined and the experimental tie...detailed

Enantioseparation of PHENYLSUCCINIC ACID (cas 10424-29-0) by high speed counter-current chromatography using hydroxypropyl-β-cyclodextrin as chiral selector08/04/2019

High speed counter-current chromatography (HSCCC) was successfully applied to resolution of phenylsuccinic acid (PSA) with hydroxypropyl-β-cyclodextrin (HP-β-CD) as chiral selector (CS). The two-phase solvent system composed of n-hexane–methyl tert-butyl ether–0.1 mol L−1 phosphate buffer so...detailed

Equilibrium Studies on Liquid-Liquid Reactive Extraction of PHENYLSUCCINIC ACID (cas 10424-29-0) Enantiomers Using Hydrophilic β-CD Derivatives Extractants07/31/2019

This paper deals with the enantioseparation of phenylsuccinic acid (H2A) enantiomers by liquid-liquid reactive extraction using β-CD derivatives as aqueous selectors. Cyclodextrin and its derivatives can interact with guest molecules selectively to form complexes with different stabilities. Cyc...detailed

Relevant academic research and scientific papers

Cu/PCy3-Catalyzed Formal Carbene Insertion into Electron-Deficient C?H Bonds

A carbene insertion into electron-deficient C?H bonds of 1,3-diesters, β-ketoesters, β-ketonitriles, and malononitriles was realized by using CuCN/PCy3 as the catalyst. The reaction provides a straightforward approach to the synthetically important multi-substituted succinic acid derivatives. A plausible reaction mechanism with cyclopropanation/ring opening as key steps was proposed based on control experiments.

Enamines; 45. A New Simple Synthesis of 2-Phenylsuccinic Acids

A simple route to 2-phenylsuccinic acids consists of the reaction of 1,1-dimorpholinoethene with β-nitrostyrenes at room temperature and hydrolysis of the 1:1 adduct thus obtained with hydrochloric acid.The method affords good overall yields of 2-phenylsuccinic acids.

Discovery, stereospecific characterization and peripheral modification of 1-(pyrrolidin-1-ylmethyl)-2-[(6-chloro-3-oxo-indan)-formyl]-1,2,3,4-tetrahydroisoquinolines as novel selective κ opioid receptor agonists

A novel series of 1-(pyrrolidin-1-ylmethyl)-2-[(3-oxo-indan)-formyl]-1,2,3,4-tetrahydroisoquinoline derivatives maj-3a-maj-3u were synthesized and evaluated in vitro for their binding affinity at κ-opioid receptors. Maj-3c displayed the highest affinity for κ-opioid receptors (Ki = 0.033 nM) among all the compounds evaluated. Furthermore, all four stereoisomers of compound 3c were prepared, and (1S,18S)-3c was identified as the most potent (Ki = 0.0059 nM) κ-opioid receptor agonist among the four stereoisomers. Maj-3c produced significant antinociception (ED50 = 0.000406 mg kg-1) compared to U-50,488H and original BRL 52580 in the acetic acid writhing assay, but its strong sedative effect (ED50 = 0.000568 mg kg-1) observed in the mouse rotation test reduced its druggability. To minimize the central nervous system side effects, a series of hydroxyl-containing analogs of maj-3c were synthesized, and maj-11a was found to be a potent κ-opioid receptor agonist (Ki = 35.13 nM). More importantly, the dose for the sedative effect (ED50 = 9.29 mg kg-1) of maj-11a was significantly higher than its analgesic dose (ED50 = 0.392 mg kg-1), which made it a promising peripheral analgesic candidate compound with weak sedative side effects.

Photoredox Activation of Formate Salts: Hydrocarboxylation of Alkenes via Carboxyl Group Transfer

A photoredox activation mode of formate salts for carboxylation was developed. Using a formate salt as the reductant, carbonyl source, and hydrogen atom transfer reagent, a wide range of alkenes can be converted into acid products via a carboxyl group tra

Harnessing Applied Potential: Selective β-Hydrocarboxylation of Substituted Olefins

The construction of carboxylic acid compounds in a selective fashion from low value materials such as alkenes remains a long-standing challenge to synthetic chemists. In particular, β-addition to styrenes is underdeveloped. Herein we report a new electrosynthetic approach to the selective hydrocarboxylation of alkenes that overcomes the limitations of current transition metal and photochemical approaches. The reported method allows unprecedented direct access to carboxylic acids derived from β,β-trisubstituted alkenes, in a highly regioselective manner.

Stereoselective One-Pot Synthesis of cis-1,2-Dicyanoalkenes from 1,1-Bis(benzenesulfonyl)alkenes and KCN

An efficient synthesis of cis-1,2-dicyanoalkenes by the reaction of 1,1-bis(benzenesulfonyl)alkenes with KCN was developed. This reaction was conducted in the presence of tetrabutylammonium bromide and NH4Cl/K3PO4 under phase-transfer conditions. A series of cis-1,2-dicyanoalkenes were obtained in good to high yields. Further transformation of the obtained product allows for access to imide and dicarboxylic acid compounds.

Method for synthesizing succinic acid compounds

The invention provides a method for synthesizing succinic acid compounds. The method specifically comprises the following steps: adding a substrate, a photocatalyst and an alkali into a reaction tube,adding a reducing agent and a solvent under the atmosphere of CO2, conducting reacting under the irradiation of visible light, carrying out quenching treatment after the raw materials react completely, and then conducting separating and purifying to obtain a dicarboxylated product of olefin, namely a succinic acid compound. The photocatalyst is 4CzIPN or Ir[(ppy)2(dtbppy)]PF6 and the like, and the reaction substrate comprises 1,1-diaryl ethylene, a monoaryl substituted olefin compound, an acrylate compound and allene. According to the scheme provided by the invention, the reaction conditionsare mild, the applicability of the reaction substrate is wide, and the yield is basically not influenced under the condition that the reaction substrate is amplified to the gram scale; and meanwhile,the invention overcomes the defects of high toxicity of reagents and harsh reaction conditions in the prior art, and has a good industrial application prospect.

Preparation method and application of tetrahydroisoquinoline derivative

The invention discloses a preparation method of a tetrahydroisoquinoline derivative. The tetrahydroisoquinoline derivative is prepared by subjecting 1-(tetrapyrrolidin-1-yl)-1,2,3,4-tetrahydroisoquinoline and 2,3-dihydro-indene-3-one-1-carboxylic acid to condensation. Process conditions are optimized so that preparation steps are simplified. Agents used in the preparation are pollution free. The prepared tetrahydroisoquinoline derivative 1-(tetrapyrrolidin-1-methyl)-2-(2,3-dihydro-indene-3-one-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline can provide good calming effect against neuropathic pain.The tetrahydroisoquinoline derivative has high medical value in drug compositions for pain treatment and in replacing dependent analgesics, such as morphine.

Direct β-Selective Hydrocarboxylation of Styrenes with CO2 Enabled by Continuous Flow Photoredox Catalysis

The direct β-selective hydrocarboxylation of styrenes under atmospheric pressure of CO2 has been developed using photoredox catalysis in continuous flow. The scope of this methodology was demonstrated with a range of functionalized terminal styrenes, as well as α-substituted and β-substituted styrenes.

DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS

The present invention relates to novel substituted dihydropyrazolone derivatives, to their preparation and to their therapeutic use as activators of the transcription factor HIF.