1042740-91-9

Upstream product

• 35249-73-1 benzyl chlorooxalate 
• 352-13-6 4-flourophenylmagnesium bromide 
• 538-60-3 dibenzyl hydrogen phosphite 
• 403-32-7 (4-fluorophenyl)glyoxal 
• 1813-94-1 ethyl 4-fluorobenzoylformate 
• 2251-76-5 2-(4-fluorophenyl)-2-oxoacetic acid 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 1042740-60-2 benzyl 2-(4-fluorophenyl)-2-hydroxy-phenylacetate 
• 1416913-09-1 benzyl (R)-2-(4-fluorophenyl)-2-hydroxy-3-(3-oxocyclohex-1-en-1-yl)propanoate 

Relevant academic research and scientific papers

Br?nsted base-catalyzed three-component coupling reaction of α-ketoesters, imines, and diethyl phosphite utilizing [1,2]-phospha-Brook rearrangement

A three-component coupling reaction of α-ketoesters, imines, and diethyl phosphite under Br?nsted base catalysis was developed by utilizing the [1,2]-phospha-Brook rearrangement. The reaction involves the generation of ester enolates via the umpolung proc

Pd(OAc)2-Catalyzed Asymmetric Hydrogenation of α-Iminoesters

An efficient Pd(OAc)2-catalyzed asymmetric hydrogenation of α-iminoesters was realized for the first time at 1 atm hydrogen pressure and room temperature. Pd(OAc)2, a less expensive Pd salt with low toxicity, was found to be the most suitable catalyst precursor rather than Pd(TFA)2 which is usually the catalyst of choice for homogeneous asymmetric hydrogenation. The chiral α-arylglycine fragments are widely found in many chiral products and bioactive molecules.

2-Oxo promoted hydrophosphonylation & aerobic intramolecular nucleophilic displacement reaction

Highly efficient catalyst free methods for the synthesis of α-hydroxy-β-oxophosphonates and α-oxoesters have been described. The existence of a 2-oxo group in α-oxoaldehydes is a key factor in promoting the reaction of the tervalent phosphite form towards 2-oxoaldehydes in the synthesis of α-hydroxy-β-oxophosphonates. The in situ activated α-C-H atom of α-hydroxy-β-oxophosphonates sustains aerobic intramolecular nucleophilic displacement in a curious way to produce α-oxoester.

Enantioselective rhodium-catalyzed addition of arylboronic acids to α-ketoesters

(Chemical Figure Presented) Rhodium catalysis: The first example of a catalytic asymmetric addition of arylboronic acids to α-ketoesters was realized by using a chiral RhI-spirophosphite ligand complex in aqueous solvent to provide tertiary α-hydroxyesters in good yields with high enantioselectivities (see scheme; DCE = 1,2-dichloroethane).