1043-46-5

Basic information

• Product Name: 1H-1,2,4-Triazole, 1,3,5-triphenyl-
• CAS NO: 1043-46-5
• Molecular Formula: C20H15N3
• Molecular Weight: 297.359
• Mol File: 1043-46-5.mol
• Article Data: 35

Chemical Properties

• CAS DataBase Reference: 1H-1,2,4-Triazole, 1,3,5-triphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-Triazole, 1,3,5-triphenyl-(1043-46-5)
• EPA Substance Registry System: 1H-1,2,4-Triazole, 1,3,5-triphenyl-(1043-46-5)

Safety Data

• Hazardous Substances Data: 1043-46-5(Hazardous Substances Data)

Usage

Family

Triazole family of compounds

Biological Activities

Diverse range of biological activities

Derivative

Triphenyl derivative of 1H-1,2,4-triazole

Usage

Building block in the synthesis of other organic compounds

Pharmacological Properties

Potential as an antifungal, antibacterial, and anticancer agent

Therapeutic Properties

Potential as an antifungal, antibacterial, and anticancer agent

Investigated Applications

Fluorescent sensors and dyes

Versatility

Wide range of potential applications in various fields of chemistry and biology

Upstream product

• 18039-45-7 2,5-diphenyl-2H-tetrazole 
• 100-47-0 benzonitrile 
• 618-39-3 benzamidin 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 36879-86-4 2,4-diphenyl-2H-oxazol-5-one 
• 4194-36-9 N-<(Phenylthioxo)-methyl>benzamide 
• 100-63-0 phenylhydrazine 
• 89168-51-4 N-benzylbenzamide phenylhydrazone 
• 54214-63-0 1,3,5-triphenyl-1H-1,2,4-triazole 2-oxide 
• 98-88-4 benzoyl chloride 
• 108-86-1 bromobenzene 
• 100-46-9 benzylamine 
• 34102-49-3 7-azabicyclo<4.2.0>octan-8-one 
• 128694-15-5 7-azabicyclo<4.2.0>octan-8-thione 

Relevant articles and documents

The reaction of α-chlorocarbenium salts with nitriles: formation of chloro-substituted 2-azoniaallene salts

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TBHP/TBAI–Mediated simple and efficient synthesis of 3,5-disubstituted and 1,3,5-trisubstituted 1H-1,2,4-triazoles via oxidative decarbonylation of aromatic aldehydes and testing for antibacterial activities

The author has developed a simple, efficient and eco–friendly convenient general method for synthesis of 3,5–disubstituted–1,2,4–triazoles and 1,3,5–trisubstituted–1,2,4–triazoles from 3–monosubstituted–1,2,4–triazoles and 1,3–disubstituted–1,2,4–triazoles respectively using tetrabutylammonium iodide (TBAI) as catalyst and TBHP as oxidant under mid reaction conditions. This method provides structurally diverse 3,5–disubstituted 1,2,4–triazoes and 1,3,5––trisubstituted–1,2,4–triazoles in good to excellent yields. 3,5–Disubstituted 1,2,4–triazoes and 1,3,5––trisubstituted–1,2,4–triazoles derivatives are biologically and pharmaceutically active molecules, and therefore, this protocol could be of wide applications in medicinal chemistry and organic chemistry.

Electrosynthesis of 1,3,5-trisubstituted 1,2,4-triazoles from phenylhydrazine, aldehydes and amines under mild conditions

A simple and convenient method for the electrosynthesis of 1,3,5-trisubstituted 1,2,4-triazoles with three components of phenylhydrazine, aldehydes and amines has been established. The electrolysis could be smoothly carried out at room temperature without additional strong oxidants and catalysts to afford the target product in good yields. This electrochemical route effectively extends synthetic field of 1,2,4-triazole derivatives.

Method for preparing 1,3,5-trisubstituted-1,2,4-triazole derivative in one step

The invention discloses a method for preparing a 1,3,5-trisubstituted-1,2,4-triazole derivative in one step, and belongs to the technical field of organic chemical synthesis. According to the method,a simple nitrile compound and a hydrazine compound are u