104375-65-7Relevant academic research and scientific papers
Aza-heterocycles via copper-catalyzed, remote C–H desaturation of amines
Dare, Ross M.,Nagib, David A.,Paneque, Alyson N.,Stateman, Leah M.
supporting information, p. 210 - 224 (2022/01/19)
A majority of medicines contain a nitrogen atom within a five- or six-membered ring. To rapidly access both such aza-heterocycles, we sought to develop a remote C–H desaturation of amines. Inspired by the Hofmann-L?ffler-Freytag (HLF) synthesis of five-me
ATM KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
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Paragraph 0618, (2021/06/11)
Provided are certain ATM kinase inhibitors of Formula (I). Also provided herein are compositions of such compounds, and methods of their use.
Palladium-Catalyzed Alkene Carboamination Reactions of Electron-Poor Nitrogen Nucleophiles
Peterson, Luke J.,Wolfe, John P.
supporting information, p. 2339 - 2344 (2015/07/27)
Modified reaction conditions that facilitate Pd-catalyzed alkene carboamination reactions of electron-deficient nitrogen nucleophiles are reported. Pent-4-enylamine derivatives bearing N-tosyl or N-trifluoroacetyl groups are coupled with aryl triflates to
NHC-Catalyzed intramolecular redox amidation for the synthesis of functionalized lactams
Thai, Karen,Wang, Li,Dudding, Travis,Bilodeau, Francois,Gravel, Michel
, p. 5708 - 5711 (2011/03/19)
A very efficient NHC-catalyzed lactamization reaction is reported. For most cases, the ring expansion reaction proceeds to cleanly furnish five- and six-membered N-Ts and N-Bn lactams, without the need for further purification. Evidence is presented suggesting a dual role for the stoichiometric base: (1) deprotonation of the triazolium precatalyst and (2) activation of the nitrogen leaving group through hydrogen bonding.
